Cdkn1c^tm1Sje
Targeted Allele Detail

Summary

• Symbol: Cdkn1c^tm1Sje
• Name: cyclin dependent kinase inhibitor 1C; targeted mutation 1, SJ Elledge
• MGI ID: MGI:1861811
• Synonyms: Cdkn1c^-, p57^-, p57^KIP2, p57^+/-m
• Gene: Cdkn1c Location: Chr7:143012076-143014735 bp, - strand Genetic Position: Chr7, 88.22 cM
• Alliance: Cdkn1c^tm1Sje page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:40203
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Replacement of exons 1 and 2 (87% of the Cdkn1c coding region) with a neomycin cassette. (J:40203)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	113 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdkn1c Mutation: 19 strains or lines available

References

• Original: J:40203 Zhang P, et al., Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome. Nature. 1997 May 8;387(6629):151-8
• All: 34 reference(s)