Cdkn1a^{tm1(HBsAg)Xya}
Targeted Allele Detail

Summary

• Symbol: Cdkn1a^{tm1(HBsAg)Xya}
• Name: cyclin dependent kinase inhibitor 1A; targeted mutation 1, Xiao Yang
• MGI ID: MGI:3039362
• Synonyms: p21^HBsAg
• Gene: Cdkn1a Location: Chr17:29309953-29319696 bp, + strand Genetic Position: Chr17, 15.12 cM
• Alliance: Cdkn1a^{tm1(HBsAg)Xya} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:88078
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 2 was replaced with a floxed neo cassette and sequence encoding the hepatitis B virus surface antigen (HBsAg). Endogenous transcript was undetected by RT-PCR analysis of homozygous mutant mice. (J:88078)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cdkn1a Mutation: 60 strains or lines available

References

• Original: J:88078 Wang Y, et al., HBsAg and HBx knocked into the p21 locus causes hepatocellular carcinoma in mice. Hepatology. 2004 Feb;39(2):318-24
• All: 1 reference(s)