Zfpm2tm1.1Esv
Targeted Allele Detail
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Symbol: |
Zfpm2tm1.1Esv |
Name: |
zinc finger protein, multitype 2; targeted mutation 1.1, Eric C Svensson |
MGI ID: |
MGI:5661400 |
Synonyms: |
FOG-2R3K5A |
Gene: |
Zfpm2 Location: Chr15:40518438-40967988 bp, + strand Genetic Position: Chr15, 15.74 cM, cytoband C
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Alliance: |
Zfpm2tm1.1Esv page
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Germline Transmission: |
Earliest citation of germline transmission:
J:216295
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129S6/SvEvTac
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Allele Type: |
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Targeted (Not Applicable) |
Mutations: |
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Insertion, Nucleotide substitutions
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Mutation details: R3A and K5A mutations were inserted in exon 1 and a floxed neo cassette was inserted into intron 1 via homologous recombination. The mutation in exon 1 disrupts interaction of the protein with subunits of the nucleosome remodeling and histone deacetylase complex. Cre mediated recombination removed the neo cassette. Western blot analysis of E13.5 heart lysates revealed comparable protein levels in wild-type, heterozygous, and homozygous mutant hearts.
(J:216295)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Zfpm2 Mutation: |
47 strains or lines available
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Original: |
J:216295 Garnatz AS, et al., FOG-2 mediated recruitment of the NuRD complex regulates cardiomyocyte proliferation during heart development. Dev Biol. 2014 Nov 1;395(1):50-61 |
All: |
1 reference(s) |
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