Phenotypes associated with this allele

• Allele Symbol: Zfpm2^tm1.1Esv
• Allele Name: targeted mutation 1.1, Eric C Svensson
• Allele ID: MGI:5661400
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zfpm2^tm1.1Esv/Zfpm2^tm1.1Esv	involves: 129S1/SvImJ * 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6	MGI:5749466
ht2	Zfpm2^tm1.1Esv/Zfpm2^+	involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac	MGI:5749460
cx3	Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj Zfpm2^tm1.1Esv/Zfpm2^tm1.1Esv	involves: 129S1/SvImJ * 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6	MGI:5749463

Genotype
MGI:5749466

hm1

• Allelic Composition: Zfpm2^tm1.1Esv/Zfpm2^tm1.1Esv
• Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

thin myocardium compact layer ( J:216295 )

• at birth, mutant hearts display a thin myocardial compact zone

atrial septal defect ( J:216295 )

• atrial septal defects are present at P0

ventricular septal defect ( J:216295 )

• ventricular septal defects are present at P0

decreased ventricle muscle contractility ( J:216295 )

• at P0, echocardiography revealed a reduction in systolic function as determined by left ventricular fractional shortening

abnormal heart echocardiography feature ( J:216295 )

• at P0, echocardiographic M-mode tracings revealed a significant increase in left ventricular end systolic dimension (LVESD) relative to control mice

muscle

thin myocardium compact layer ( J:216295 )

• at birth, mutant hearts display a thin myocardial compact zone

decreased ventricle muscle contractility ( J:216295 )

• at P0, echocardiography revealed a reduction in systolic function as determined by left ventricular fractional shortening

Genotype
MGI:5749460

ht2

• Allelic Composition: Zfpm2^tm1.1Esv/Zfpm2⁺
• Genetic Background: involves: 129S1/SvImJ * 129S4/SvJae * 129S6/SvEvTac

normal phenotype

no abnormal phenotype detected ( J:216295 )

• heterozygotes are viable and fertile, display no grossly overt malformations, and have a normal lifespan

Genotype
MGI:5749463

cx3

• Allelic Composition: Cdkn1a^tm1Tyj/Cdkn1a^tm1Tyj; Zfpm2^tm1.1Esv/Zfpm2^tm1.1Esv
• Genetic Background: involves: 129S1/SvImJ * 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6

muscle

abnormal myocardium compact layer morphology ( J:216295 )

• at birth, double homozygotes display a significantly thicker myocardial compact zone than single Zfpm2^tm1.1Esv homozygotes; however, left ventricular wall thickness is still not completely normal

mortality/aging

postnatal lethality, complete penetrance ( J:216295 )

• double homozygotes die by P14, possibly due to septal defects

cardiovascular system

abnormal myocardium compact layer morphology ( J:216295 )

• at birth, double homozygotes display a significantly thicker myocardial compact zone than single Zfpm2^tm1.1Esv homozygotes; however, left ventricular wall thickness is still not completely normal

atrial septal defect ( J:216295 )

• atrial septal defects are still present at P0

ventricular septal defect ( J:216295 )

• ventricular septal defects are still present at P0

abnormal heart left ventricle wall thickness ( J:216295 )

• at birth, double homozygotes show only a modest 26.8 +/- 3.2% rescue of left ventricular wall thickness relative to wild-type controls

• however, left ventricular fractional shortening is preserved, indicating that increased wall thickness improves left ventricular function

abnormal heart echocardiography feature ( J:216295 )

• at P0, echocardiographic M-mode tracings revealed a slight increase in left ventricular end diastolic dimension (LVEDD) relative to wild-type controls, suggesting that mutant hearts are starting to dilate and fail