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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Stat3
signal transducer and activator of transcription 3
MGI:103038
204 phenotypes from 16 alleles in 27 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gt(ROSA)26Sortm1(Stat3*A661C*N663C)Sbkv/Gt(ROSA)26Sortm1(Stat3*A661C*N663C)Sbkv
involves: C57BL/6 		abnormal T-helper 17 cell differentiation J:205858
Gt(ROSA)26Sortm1(Stat3*A661C*N663C)Sbkv/Gt(ROSA)26Sortm1(Stat3*A661C*N663C)Sbkv
Tg(Agrp-cre)1Gsb/?
involves: C57BL/6 * FVB/N 		abnormal glucose homeostasis J:133218
decreased circulating adrenaline level J:133218
decreased circulating glucose level J:133218
decreased circulating insulin level J:133218
decreased circulating noradrenaline level J:133218
decreased gonadal fat pad weight J:133218
improved glucose tolerance J:133218
increased locomotor activity J:133218
increased oxygen consumption J:133218
polyphagia J:133218
slow postnatal weight gain J:133218
Gt(ROSA)26Sortm1(Stat3*A661C*N663C)Sbkv/Gt(ROSA)26Sortm1(Stat3*A661C*N663C)Sbkv
Tg(Cd4-cre)1Cwi/0
involves: C57BL/6 * DBA/2 		decreased lung compliance J:205858
increased airway resistance J:205858
increased circulating interleukin-17 level J:205858
increased interleukin-17 secretion J:205858
increased lung elastance J:205858
increased regulatory T cell number J:205858
increased T-helper 1 cell number J:205858
increased T-helper 17 cell number J:205858
lung inflammation J:205858
premature death J:205858
Stat3tm1Aki/Stat3tm1Aki
involves: 129P2/OlaHsd 		absent mesoderm J:40106
decreased embryo size J:40106
decreased inner cell mass proliferation J:40106
embryonic lethality between implantation and somite formation, complete penetrance J:40106
failure to gastrulate J:40106
Stat3tm1Aki/Stat3tm1Aki
Tg(Tek-cre)12Flv/0
involves: 129P2/OlaHsd * C3H * C57BL/6 		abnormal interleukin level J:123351
Stat3tm1Aki/Stat3tm2Aki
Tg(Col1a1-cre)1Kry/0
involves: 129P2/OlaHsd * FVB/N * C57BL/6 		abnormal bone ossification J:144906
abnormal bone structure J:144906
decreased trabecular bone thickness J:144906
Stat3tm1Aki/Stat3tm2Aki
Tg(NEFL-cre)50Msd/0
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * CD-1 		abnormal motor neuron morphology J:77229
abnormal neuron physiology J:77229
increased susceptibility to injury J:77229
Stat3tm1Desi/Stat3tm1Desi
involves: 129X1/SvJ * C57BL/6 		increased susceptibility to endotoxin shock J:77307
Stat3tm1Dlv/Stat3tm1Dlv
Tg(Cd4-cre)1Cwi/?
involves: 129 * C57BL/6 * DBA/2 		abnormal CD4-positive T cell differentiation J:124293
abnormal gut-associated lymphoid tissue morphology J:124293
decreased interleukin-17 secretion J:124293
increased interferon-gamma secretion J:124293
Stat3tm1Dlv/Stat3tm1Dlv
Tg(Cryaa-cre)10Mlr/0
involves: C57BL/6 		normal vision/eye phenotype J:88422
Stat3tm1Dlv/Stat3tm1Dlv
Tg(Csf1r-icre)1Jwp/0
involves: 129P2/OlaHsd * C57BL/6 * FVB 		abnormal acute inflammation J:156593
abnormal cecum morphology J:156593
abnormal colon morphology J:156593
abnormal inflammatory response J:156593
abnormal intestinal mucosa morphology J:156593
colitis J:156593
colon polyps J:156593
decreased body weight J:156593
decreased locomotor activity J:156593
diarrhea J:156593
increased carcinoma incidence J:156593
increased gastrointestinal tumor incidence J:156593
increased granulocyte number J:156593
increased macrophage cell number J:156593
increased T cell number J:156593
weight loss J:156593
Stat3tm1Dlv/Stat3tm1Dlv
Tg(MMTV-cre)4Mam/0
involves: 129P2/OlaHsd * C57BL/6J * FVB 		decreased T-helper 17 cell number J:120176
Stat3tm1Dnl/Stat3tm1Dlv
involves: C57BL/6 		abnormal circulating insulin-like growth factor I level J:87599
decreased body size J:87599
decreased body weight J:87599
decreased growth hormone level J:87599
decreased thymocyte number J:87599
decreased urine protein level J:87599
fetal growth retardation J:87599
increased thymocyte apoptosis J:87599
postnatal growth retardation J:87599
postnatal lethality, incomplete penetrance J:87599
Stat3tm1Dnl/Stat3tm1Dnl
involves: C57BL/6 		no abnormal phenotype detected J:87599
Stat3tm1Flv/Stat3tm1Flv
Tg(Nes-cre)1Kln/0
involves: C57BL/6 * SJL 		abnormal body temperature homeostasis J:89242
abnormal brown adipose tissue morphology J:89242
abnormal glucose homeostasis J:89242
abnormal white adipose tissue morphology J:89242
absent corpus luteum J:89242
anovulation J:89242
decreased body length J:89242
decreased body temperature J:89242
decreased energy expenditure J:89242
decreased food intake J:89242
enlarged liver J:89242
female infertility J:89242
hepatic steatosis J:89242
hyperglycemia J:89242
impaired adaptive thermogenesis J:89242
impaired glucose tolerance J:89242
increased circulating corticosterone level J:89242
increased circulating insulin level J:89242
increased circulating leptin level J:89242
increased circulating triglyceride level J:89242
increased total body fat amount J:89242
insulin resistance J:89242
male infertility J:89242
neonatal lethality, incomplete penetrance J:89242
obese J:89242
polyphagia J:89242
short uterine horn J:89242
small seminal vesicle J:89242
small testis J:89242
Stat3tm1Flv/Stat3tm1Flv
Tg(Tek-cre)1Xyfu/0
involves: C57BL/6 		abnormal cytokine secretion J:86655
increased susceptibility to endotoxin shock J:86655
Stat3tm1Flv/Stat3tm1Flv
Tg(Tek-cre)12Flv/0
involves: 129 * C3H * C57BL/6 		abnormal cecum morphology J:81973
abnormal colon morphology J:81973
abnormal ileum morphology J:81973
abnormal inflammatory response J:81973
abnormal innate immunity J:81973
abnormal intestine morphology J:81973
abnormal T-helper 1 physiology J:81973
cecum inflammation J:81973
colitis J:81973
decreased body size J:81973
decreased body weight J:81973
decreased NAD(P)H oxidase activity J:81973
granulomatous inflammation J:81973
ileum inflammation J:81973
increased circulating interferon-gamma level J:81973
increased circulating tumor necrosis factor level J:81973
increased leukocyte cell number J:81973
intestinal inflammation J:81973
intestinal ulcer J:81973
liver inflammation J:81973
premature death J:81973
weakness J:81973
Stat3tm1Jbha/Stat3tm1Jbha
Tg(Fabp4-cre)1Rev/0
involves: 129S/SvEv * C57BL/6 		decreased circulating adiponectin level J:136030
increased body weight J:136030
increased brown adipose tissue amount J:136030
increased fat cell size J:136030
increased gonadal fat pad weight J:136030
increased inguinal fat pad weight J:136030
increased liver weight J:136030
increased percent body fat/body weight J:136030
increased retroperitoneal fat pad weight J:136030
increased total body fat amount J:136030
Stat3tm1Vpo/Stat3+
Tg(Myh6-cre)2182Mds/0
involves: 129P2/OlaHsd * FVB/N 		cardiomyopathy J:141591
congestive heart failure J:141591
generalized edema J:141591
pregnancy-related premature death J:141591
Stat3tm1Vpo/Stat3tm1Vpo
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
involves: 129P2/OlaHsd * C57BL/6 * DBA 		increased incidence of tumors by chemical induction J:172422
Stat3tm1Vpo/Stat3tm1Vpo
Tg(Mx1-cre)1Cgn/0
involves: 129P2/OlaHsd * BALB/cAn * C57BL/6 * CBA 		abnormal macrophage physiology J:89194
increased interleukin-6 secretion J:89194
increased tumor necrosis factor secretion J:89194
Stat3tm1Vpo/Stat3tm1Vpo
Tg(Myh6-cre)2182Mds/0
involves: 129P2/OlaHsd * FVB/N 		abnormal angiogenesis J:141591
abnormal atrial thrombosis J:141591
abnormal heart echocardiography feature J:141591
abnormal myocardial fiber morphology J:141591
cardiac fibrosis J:141591
cardiomyopathy J:141591
congestive heart failure J:141591
decreased cardiac muscle contractility J:141591
dilated heart J:141591
dilated heart left ventricle J:141591
generalized edema J:141591
increased cardiomyocyte apoptosis J:141591
oxidative stress J:141591
pregnancy-related premature death J:141591
Stat3tm1Vpo/Stat3tm2Vpo
Tg(Mx1-cre)1Cgn/0
involves: C57BL/6 * CBA * BALB/cAn 		abnormal macrophage physiology J:89194
increased interleukin-6 secretion J:89194
increased tumor necrosis factor secretion J:89194
Stat3tm1Xyfu/Stat3+
involves: 129S1/Sv * C57BL/6 		increased susceptibility to induced morbidity/mortality J:128719
Stat3tm1Xyfu/Stat3+
Tg(Myh6-cre)2182Mds/0
involves: 129S1/Sv * FVB/N 		cardiac fibrosis J:86400
increased susceptibility to endotoxin shock J:86400
increased tumor necrosis factor secretion J:86400
Stat3tm1Xyfu/Stat3tm1.1Xyfu
Tg(Myh6-cre)2182Mds/0
involves: 129S1/Sv * FVB/N 		abnormal cardiovascular system physiology J:86400
ascites J:86400
cachexia J:86400
cardiac fibrosis J:86400
congestive heart failure J:86400
decreased cardiac muscle contractility J:86400
dilated heart J:86400
enlarged heart J:86400
increased cardiomyocyte apoptosis J:86400
increased heart left ventricle size J:86400
increased physiological sensitivity to xenobiotic J:86400
increased susceptibility to endotoxin shock J:86400
increased tumor necrosis factor secretion J:86400
respiratory distress J:86400
Stat3tm1Xyfu/Stat3tm1.1Xyfu
Tg(Ttr-cre)10-3Xyfu/?
involves: 129S1/Sv * C57BL/6 		decreased hepatocyte proliferation J:128719
increased monocyte cell number J:128719
increased neutrophil cell number J:128719
increased susceptibility to induced morbidity/mortality J:128719
Stat3tm2Aki/Stat3tm2Aki
involves: 129 * 129P2/OlaHsd * C57BL/6 * FVB/N 		abnormal eating behavior J:131301
increased body length J:131301
increased circulating glucose level J:131301
increased circulating insulin level J:131301
obese J:131301
normal reproductive system phenotype J:131301
Stat3tm2Aki/Stat3tm2Aki
involves: 129P2/OlaHsd * BALB/c * C57BL/6 		abnormal response to infection J:122213
Stat3tm2Aki/Stat3tm2Aki
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129P2/OlaHsd * 129S4/SvJaeSor 		no abnormal phenotype detected J:226497
Stat3tm2Aki/Stat3tm2Aki
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * C57BL/6 		abnormal colon morphology J:83280
colitis J:83280
increased CD4-positive, alpha-beta T cell number J:83280
increased dendritic cell number J:83280
increased interferon-gamma secretion J:83280
increased interleukin-12 secretion J:83280
increased macrophage cell number J:83280
Stat3tm2Aki/Stat3tm2Aki
Tg(Alb1-cre)1Dlr/0
involves: 129P2/OlaHsd * FVB/N 		abnormal glucose homeostasis J:109359
Stat3tm2Aki/Stat3tm2Aki
Tg(KRT5-cre)1Tak/0
involves: 129P2/OlaHsd * C3H * C57BL/6 		abnormal eye morphology J:194832
abnormal hair cycle anagen phase J:65302
abnormal hair follicle morphology J:65302
acanthosis J:65302
conjunctivitis J:194832
decreased hair follicle number J:65302
decreased keratinocyte migration J:65302
dermatitis J:194832
hyperkeratosis J:65302
impaired wound healing J:65302
lacrimal gland inflammation J:194832
skin fibrosis J:65302
spontaneous skin ulceration J:65302
Stat3tm2Aki/Stat3tm2Aki
Tg(KRT5-cre/ERT2)AJdg/0
involves: 129P2/OlaHsd * FVB/N 		abnormal epidermal layer morphology J:138529
decreased incidence of tumors by chemical induction J:138529
increased apoptosis J:138529
Stat3tm2Aki/Stat3tm2Aki
Tg(Lck-cre)1Jtak/0
involves: 129P2/OlaHsd 		decreased T cell proliferation J:50443
increased T cell apoptosis J:50443
Stat3tm2Aki/Stat3tm2Aki
Tg(SFTPC-rtTA)5Jaw/0
Tg(tetO-cre)1Jaw/0
involves: 129 * 129P2/OlaHsd * C57BL/6 		abnormal cytokine level J:87622
abnormal lung vasculature morphology J:87622
abnormal pulmonary alveolus epithelial cell morphology J:87622
abnormal respiratory mechanics J:87622
abnormal surfactant secretion J:87622
decreased lung compliance J:87622
decreased type II pneumocyte number J:87622
increased airway resistance J:87622
increased lung elastance J:87622
increased lung tissue damping J:87622
increased susceptibility to injury J:87622
lung inflammation J:87622
normal mortality/aging J:87622
pulmonary epithelial necrosis J:87622
pulmonary hyaline membrane formation J:87622
respiratory distress J:87622
respiratory failure J:87622
normal respiratory system phenotype J:87622
Stat3tm2Vpo/Stat3tm2Vpo
involves: C57BL/6 * CBA * BALB/cAn 		perinatal lethality, complete penetrance J:89194
Stat3tm3Vpo/Stat3tm3Vpo
involves: C57BL/6 * CBA * BALB/cAn 		abnormal macrophage physiology J:89194
Stat3tm4Vpo/Stat3tm4Vpo
involves: 129P2/OlaHsd * BALB/cAn 		preweaning lethality, complete penetrance J:157976
Tg(KRT5-Stat3*A661C*N663C)1Jdg/0
involves: FVB 		abnormal skin morphology J:95458
absent epidermis stratum granulosum J:95458
acanthosis J:95458
hyperkeratosis J:95458
increased keratinocyte proliferation J:95458
mixed cellular infiltration to dermis J:95458
parakeratosis J:95458
psoriasis J:95458
reddish skin J:95458
scaly skin J:95458
thick skin J:95458
Tg(Stat3*)9199Alau/0
involves: C57BL/6 		abnormal CD4-positive, alpha-beta T cell physiology J:210877
abnormal T-helper 17 cell differentiation J:210877
decreased IgG1 level J:210877
decreased IgG3 level J:210877
increased IgE level J:210877
increased inflammatory response J:210877
increased neutrophil cell number J:210877
increased susceptibility to bacterial infection J:210877
increased susceptibility to bacterial infection induced morbidity/mortality J:210877
increased susceptibility to endotoxin shock J:210877
intestinal inflammation J:210877
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04/16/2024
MGI 6.23 		The Jackson Laboratory