Stat3^tm1.1Xyfu
Targeted Allele Detail

Summary

• Symbol: Stat3^tm1.1Xyfu
• Name: signal transducer and activator of transcription 3; targeted mutation 1.1, Xin-Yuan Fu
• MGI ID: MGI:3768533
• Synonyms: Stat3^D
• Gene: Stat3 Location: Chr11:100777632-100830447 bp, - strand Genetic Position: Chr11, 63.82 cM
• Alliance: Stat3^tm1.1Xyfu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:86400
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre-mediated recombination was used to delete exons 18, 19 and 20. These exons encode an SH2 domain essential for protein function. The absence of protein product was confirmed by western blot on liver tissue. (J:86400, J:128719)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stat3 Mutation: 70 strains or lines available

References

• Original: J:86400 Jacoby JJ, et al., Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced age. Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12929-34
• All: 4 reference(s)