Sod2
Gene Detail

Symbol Name ID

Sod2 superoxide dismutase 2, mitochondrial MGI:98352

Synonyms

manganese SOD, manganese superoxide dismutase, MGC:6144, MnSOD, Sod-2

Feature Type

protein coding gene

Genetic Map

Chromosome 17

8.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(18)

Sequence Map

Chr17:13007839-13018119 bp, + strand From NCBI annotation of GRCm38   10281 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:530  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: superoxide dismutase, Mn/Fe specific
Gene Tree: Sod2

Human homologs

Human Homolog		SOD2, superoxide dismutase 2, mitochondrial
NCBI Gene ID		6648
neXtProt AC		NX_P04179
Human Synonyms		IPOB, MNSOD, MVCD6
Human Chr (Location)		6q25.3; chr6:160100148-160114353 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SOD2

Alleles and phenotypes

All alleles(16) : Targeted(6) Gene trapped(10)
 

Mutations affect mitochondrial function. Null homozygotes die early with cardiomyopathy, tissue lipid accumulation, neurodegeneration, motor problems and/or metabolic acidosis depending on strain background. Heterozygotes show mitochondria and apoptosis defects with age.

 
Human Diseases Modeled Using Mouse Sod2 (3)    Alleles Annotated to Human Diseases(1)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (89 annotations)

Process	age-dependent response to oxidative stress, age-dependent response to reactive oxygen species, ...
Component	cytoplasm, mitochondrial inner membrane, ...
Function	DNA binding, identical protein binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (15 records)
Data Summary: Results (820)    Tissues (349)    Images (59)
Theiler Stages: 4, 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	168
RNA in situ	555
Western blot	49
RT-PCR	48

cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(31) Genomic(3) cDNA(22) Primer pair(5) Other(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000006818 (Evidence)
Entrez Gene	20656 (Evidence)
DFCI	TC1572750, TC1601813, TC1648584, TC1696074
DoTS	DT.101405704, DT.486387, DT.99844676
EC	1.15.1.1
Consensus CDS Project	CCDS28399.1
International Mouse Knockout Project Status	Sod2

Sequences

Length	Strain/Species
genomic	20656	NCBI Gene Model | MGI Sequence Detail	10281	C57BL/6J
transcript	NM_013671	RefSeq | MGI Sequence Detail	3824	C57BL/6
polypeptide	P09671	UniProt | EBI | MGI Sequence Detail	222	Not Applicable

All sequences(40) RefSeq(2) UniProt(4)

Polymorphisms

All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs(46 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001189	Manganese/iron superoxide dismutase
InterPro	IPR019833	Manganese/iron superoxide dismutase, binding site
InterPro	IPR019832	Manganese/iron superoxide dismutase, C-terminal
InterPro	IPR019831	Manganese/iron superoxide dismutase, N-terminal
Protein Ontology	PR:000015400	superoxide dismutase [Mn], mitochondrial

Graphical View of Protein Domain Structure

References

(Earliest) J:5406 Creagan R, et al., Chromosome assignments of genes in man using mouse-human somatic cell hybrids: mitochondrial superoxide dismutase (indophenol oxidase-B, tetrameric) to chromosome 6. Humangenetik. 1973 Dec 10;20(3):203-9
(Latest) J:192570 Parajuli N, et al., Role of reduced manganese superoxide dismutase in ischemia-reperfusion injury: a possible trigger for autophagy and mitochondrial biogenesis?. Am J Physiol Renal Physiol. 2013 Feb;304(3):F257-67
All references(210)

Other accession IDs

MGD-MRK-14484, MGD-MRK-14486