About   Help   FAQ
Sod2 Gene Detail
Summary
  • Symbol
    Sod2
  • Name
    superoxide dismutase 2, mitochondrial
  • Synonyms
    manganese SOD, manganese superoxide dismutase, MGC:6144, MnSOD, Sod-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98352
    NCBI Gene: 20656
  • Gene Overview
    MyGene.info: SOD2
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:13007839-13018119 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 8.75 cM
  • Mapping Data
    18 experiments
Strain
Comparison
more
  • SNPs within 2kb
    53 from dbSNP Build 142
  • Strain Annotations
    16
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98352
protein coding gene Chr17:13007839-13018119 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023158
protein coding gene Chr17:10720848-10731660 (+)
A/J MGP_AJ_G0023126
protein coding gene Chr17:10521145-10534545 (+)
AKR/J MGP_AKRJ_G0023090
protein coding gene Chr17:10390159-11255998 (+)
BALB/cJ MGP_BALBcJ_G0023126
protein coding gene Chr17:10303191-11122439 (+)
C3H/HeJ MGP_C3HHeJ_G0022888
protein coding gene Chr17:10602834-10611721 (+)
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ MGP_CASTEiJ_G0022402
protein coding gene Chr17:10702833-11394376 (+)
CBA/J MGP_CBAJ_G0022861
protein coding gene Chr17:11523369-11533559 (+)
DBA/2J MGP_DBA2J_G0022993
protein coding gene Chr17:10164401-10175270 (+)
FVB/NJ MGP_FVBNJ_G0022964
protein coding gene Chr17:10088627-10893540 (+)
LP/J MGP_LPJ_G0023065
protein coding gene Chr17:10557091-11471167 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022983
protein coding gene Chr17:11155698-11179011 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023595
protein coding gene Chr17:10635648-11434413 (+)
PWK/PhJ MGP_PWKPhJ_G0022149
protein coding gene Chr17:9853241-9860669 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021981
protein coding gene Chr17:10056982-10516699 (+)
WSB/EiJ MGP_WSBEiJ_G0022460
protein coding gene Chr17:10951057-10960097 (+)



Homology
more
  • Human Ortholog
    SOD2, superoxide dismutase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SOD2, superoxide dismutase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IPOB, IPO-B, Mn-SOD, MNSOD, MVCD6
  • Links
    NCBI Gene ID: 6648
    neXtProt AC: NX_P04179
    UniProt: P04179

  • Chr Location
    6q25.3; chr6:159679064-159762529 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    5 with Sod2 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
IDs
View 1 model
IDs
View 2 models
IDs
View 1 model
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    165 phenotypes from 8 alleles in 15 genetic backgrounds
    18 phenotypes from multigenic genotypes
    2 images
    160 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutations affect mitochondrial function. Null homozygotes die early with cardiomyopathy, tissue lipid accumulation, neurodegeneration, motor problems and/or metabolic acidosis depending on strain background. Heterozygotes show mitochondria and apoptosis defects with age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20656 NCBI Gene Model | MGI Sequence Detail 10281 C57BL/6J ±  kb
    transcript NM_013671 RefSeq | MGI Sequence Detail 3824 C57BL/6  
    polypeptide P09671 UniProt | EBI | MGI Sequence Detail 222 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000015400 superoxide dismutase [Mn], mitochondrial
    • EC
    • InterPro Domains
      IPR001189 Manganese/iron superoxide dismutase
      IPR019833 Manganese/iron superoxide dismutase, binding site
      IPR019832 Manganese/iron superoxide dismutase, C-terminal
      IPR036314 Manganese/iron superoxide dismutase, C-terminal domain superfamily
      IPR019831 Manganese/iron superoxide dismutase, N-terminal
      IPR036324 Manganese/iron superoxide dismutase, N-terminal domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 33
      Genomic 3
      cDNA 24
      Primer pair 5
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-14484, MGD-MRK-14486
    References
    more
    • Summaries
      All 292
      Developmental Gene Expression 21
      Diseases 4
      Gene Ontology 49
      Phenotypes 160
    • Earliest
      J:5406 Creagan R, et al., Chromosome assignments of genes in man using mouse-human somatic cell hybrids: mitochondrial superoxide dismutase (indophenol oxidase-B, tetrameric) to chromosome 6. Humangenetik. 1973 Dec 10;20(3):203-9
    • Latest
      J:266157 Biswal MR, et al., Daily zeaxanthin supplementation prevents atrophy of the retinal pigment epithelium (RPE) in a mouse model of mitochondrial oxidative stress. PLoS One. 2018;13(9):e0203816

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory