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Sod2
Gene Detail
Symbol

Name
ID
Sod2
superoxide dismutase 2, mitochondrial
MGI:98352
Synonyms
manganese SOD, manganese superoxide dismutase, MGC:6144, MnSOD, Sod-2
Feature Type
protein coding gene
Genetic Map
Chromosome 17
8.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(18)
Sequence Map
Chr17:13007839-13018119 bp, + strand
From NCBI annotation of GRCm38

  10281 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:530  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SOD2
Protein SuperFamily: superoxide dismutase, Mn/Fe specific
Gene Tree: Sod2

Human
homologs
SOD2, superoxide dismutase 2, mitochondrial
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 6648
neXtProt AC: NX_P04179

Human Synonyms: IPOB, MNSOD, MVCD6

Human Chr (Location): 6q25.3; chr6:159679116-159693321 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SOD2

Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(10) Targeted(7) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations affect mitochondrial function. Null homozygotes die early with cardiomyopathy, tissue lipid accumulation, neurodegeneration, motor problems and/or metabolic acidosis depending on strain background. Heterozygotes show mitochondria and apoptosis defects with age.
 
Human Diseases Modeled in Mice Using Sod2 (3)    Mutations Annotated to Human Diseases (2)    Phenotype Images(2)
Interactions
Sod2 interacts with 266 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (15 records)
Data Summary: Results (819)    Tissues (350)    Images (59)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 168
RNA in situ 555
Western blot 49
RT-PCR 47
cDNA source data(19)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase sod2    NEW 
Molecular
reagents
All nucleic(31) Genomic(3) cDNA(22) Primer pair(5) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000006818 (Evidence)
Entrez Gene 20656 (Evidence)
DFCI TC1572750, TC1601813, TC1648584, TC1696074
DoTS DT.101405704, DT.486387, DT.99844676
EC 1.15.1.1
Consensus CDS Project CCDS28399.1
International Mouse Phenotyping Consortium Status Sod2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20656 NCBI Gene Model | MGI Sequence Detail 10281 C57BL/6J ±  kb
transcript NM_013671 RefSeq | MGI Sequence Detail 3824 C57BL/6 
polypeptide P09671 UniProt | EBI | MGI Sequence Detail 222 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(4)
Polymorphisms
All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(58 from dbSNP Build 137)    SNPs within 2kb including multiple locations(82)
Protein-related
information
ResourceIDDescription
InterPro IPR001189 Manganese/iron superoxide dismutase
InterPro IPR019833 Manganese/iron superoxide dismutase, binding site
InterPro IPR019832 Manganese/iron superoxide dismutase, C-terminal
InterPro IPR019831 Manganese/iron superoxide dismutase, N-terminal
Protein Ontology PR:000015400 superoxide dismutase [Mn], mitochondrial
Graphical View of Protein Domain Structure
References
(Earliest) J:5406 Creagan R, et al., Chromosome assignments of genes in man using mouse-human somatic cell hybrids: mitochondrial superoxide dismutase (indophenol oxidase-B, tetrameric) to chromosome 6. Humangenetik. 1973 Dec 10;20(3):203-9
(Latest) J:211617 Sakellariou GK, et al., Neuron-specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD-knockout mice. FASEB J. 2014 Apr;28(4):1666-81
All references(226)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-14484, MGD-MRK-14486

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory