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Sod2 Gene Detail
Summary
  • Symbol
    Sod2
  • Name
    superoxide dismutase 2, mitochondrial
  • Synonyms
    manganese SOD, manganese superoxide dismutase, MGC:6144, MnSOD, Sod-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98352
    NCBI Gene: 20656
  • Gene Overview
    MyGene.info: SOD2
Location & Maps
more
  • Sequence Map
    Chr17:13007839-13018119 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10281 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 8.75 cM
  • Mapping Data
    18 experiments
Homology
more
  • Human Ortholog
    SOD2, superoxide dismutase 2, mitochondrial
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SOD2, superoxide dismutase 2, mitochondrial
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IPOB, IPO-B, Mn-SOD, MNSOD, MVCD6
  • Links
    NCBI Gene ID: 6648
    neXtProt AC: NX_P04179

  • Chr Location
    6q25.3; chr6:159679116-159693321 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    3 with Sod2 mouse models; 1 with human SOD2 associations

Human Disease Mouse Models
       Amyotrophic Lateral Sclerosis 1; ALS1   OMIM: 105400 View 1 model
Canavan Disease   OMIM: 271900 View 1 model
Leigh Syndrome; LS   OMIM: 256000 View 1 model
       Microvascular Complications of Diabetes, Susceptibility to, 6; MVCD6   OMIM: 612634
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    147 phenotypes from 8 alleles in 13 genetic backgrounds
    18 phenotypes from multigenic genotypes
    2 images
    147 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    23
  • Gene trapped
    10
  • Targeted
    9
  • Transgenic
    4
  • Incidental Mutations
Mutations affect mitochondrial function. Null homozygotes die early with cardiomyopathy, tissue lipid accumulation, neurodegeneration, motor problems and/or metabolic acidosis depending on strain background. Heterozygotes show mitochondria and apoptosis defects with age.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20656 NCBI Gene Model | MGI Sequence Detail 10281 C57BL/6J ±  kb
transcript NM_013671 RefSeq | MGI Sequence Detail 3824 C57BL/6  
polypeptide P09671 UniProt | EBI | MGI Sequence Detail 222 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    53 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 31
    Genomic 3
    cDNA 22
    Primer pair 5
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-14484, MGD-MRK-14486
References
more
  • Summaries
    All 236
    Developmental Gene Expression 16
    Diseases 2
    Gene Ontology 47
    Phenotypes 147
  • Earliest
    J:5406 Creagan R, et al., Chromosome assignments of genes in man using mouse-human somatic cell hybrids: mitochondrial superoxide dismutase (indophenol oxidase-B, tetrameric) to chromosome 6. Humangenetik. 1973 Dec 10;20(3):203-9
  • Latest
    J:235420 Lark DS, et al., Enhanced mitochondrial superoxide scavenging does not improve muscle insulin action in the high fat-fed mouse. PLoS One. 2015;10(5):e0126732

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory