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Phenotypes Associated with This Genotype
Genotype
MGI:5907999
Allelic
Composition
Sod2tm1Shs/Sod2tm1Shs
Tg(Ckmm-cre)5Khn/0
Genetic
Background
involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sod2tm1Shs mutation (0 available); any Sod2 mutation (18 available)
Tg(Ckmm-cre)5Khn mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• left ventricle wall shows myocardial degeneration
• treatment with EUK-8, a superoxide dismutase and catalase mimetic, diminishes myocardial degeneration
• left ventricle wall shows myocyte disarray
• EUK-8 treated mice show diminished myocyte disarray
• progressively increasing heart-to-body weight ratio
• treatment with EUK-8, a superoxide dismutase and catalase mimetic, decreases heart weight
• diffuse fibrotic scars surrounding myocardial cells
• EUK-8 treated mice show diminished fibrosis
• heart dilatation
• increase in left ventricular end-diastolic internal dimension (LVIDd)
• EUK-8 treatment for 4 weeks decreases LVIDd
• increase in left ventricular end-diastolic internal dimension (LVIDd)
• EUK-8 treatment for 4 weeks decreases LVIDd

growth/size/body
• progressively increasing heart-to-body weight ratio
• treatment with EUK-8, a superoxide dismutase and catalase mimetic, decreases heart weight

cellular
• heart tissue exhibits oxidative DNA damage
• EUK-8 treatment attenuates oxidative DNA damage in heart tissue

homeostasis/metabolism
• telomerase activity is decreased in heart tissues, however telomere length is normal
• EUK-8 treatment restores normal telomerase activity

muscle
• left ventricle wall shows myocardial degeneration
• treatment with EUK-8, a superoxide dismutase and catalase mimetic, diminishes myocardial degeneration
• left ventricle wall shows myocyte disarray
• EUK-8 treated mice show diminished myocyte disarray


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/24/2023
MGI 6.22
The Jackson Laboratory