159 phenotypes from 6 alleles in 14 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Sod2tm1.1Kskk/Sod2+ involves: 129P2/OlaHsd * C57BL/6	abnormal myocardial fiber morphology	J:98289
	increased cardiomyocyte apoptosis	J:98289
	oxidative stress	J:98289
Sod2tm1.1Kskk/Sod2tm1.1Kskk involves: 129P2/OlaHsd * C57BL/6	abnormal myocardial fiber morphology	J:98289
	fatigue	J:98289
	oxidative stress	J:98289
	postnatal growth retardation	J:98289
	postnatal lethality, complete penetrance	J:98289
Sod2tm1Cje/Sod2+ B6.Cg-Sod2tm1Cje/Mmmh	abnormal mitochondrial physiology	J:108637
	abnormal respiratory electron transport chain	J:108637
	increased lymphoma incidence	J:87514
	increased tumor incidence	J:87514
	normal mortality/aging	J:87514
	oxidative stress	J:87514, J:108637
Sod2tm1Cje/Sod2+ D2.Cg-Sod2tm1Cje	abnormal mitochondrial physiology	J:73998
Sod2tm1Cje/Sod2+ involves: C57BL/6J * CD-1	abnormal mitochondrial physiology	J:67874
	abnormal respiratory electron transport chain	J:67874
	increased hepatocyte apoptosis	J:67874
	oxidative stress	J:67874
Sod2tm1Cje/Sod2+ involves: C57BL/6J * DBA/2J	abnormal tricarboxylic acid cycle	J:73998
Sod2tm1Cje/Sod2tm1Cje B6.Cg-Sod2tm1Cje/Mmmh	decreased fetal size	J:73998
	dilated cardiomyopathy	J:73998
	dilated heart left ventricle	J:73998
	dilated heart right ventricle	J:73998
	enlarged heart	J:73998
	lethality throughout fetal growth and development, incomplete penetrance	J:73998
	oxidative stress	J:108637
	perinatal lethality, complete penetrance	J:73998
	thin ventricular wall	J:73998
Sod2tm1Cje/Sod2tm1Cje D2.Cg-Sod2tm1Cje	abnormal blood gas level	J:73998
	abnormal blood homeostasis	J:73998
	abnormal enzyme/coenzyme level	J:73998
	abnormal mitochondrial physiology	J:73998
	abnormal urine homeostasis	J:73998
	cardiac hypertrophy	J:73998
	decreased body weight	J:73998
	decreased circulating glucose level	J:73998
	hepatic steatosis	J:73998
	hyperoxia	J:73998
	hypocapnia	J:73998
	increased blood urea nitrogen level	J:73998
	increased circulating alkaline phosphatase level	J:73998
	increased circulating aspartate transaminase level	J:73998
	increased circulating ketone body level	J:73998
	increased heart weight	J:73998
	metabolic acidosis	J:73998
	postnatal lethality, complete penetrance	J:73998
Sod2tm1Cje/Sod2tm1Cje involves: C57BL/6J	abnormal brainstem morphology	J:45913
	abnormal cerebellum morphology	J:45913
	abnormal cerebral cortex morphology	J:45913
	abnormal gait	J:45913
	abnormal optic nerve morphology	J:71457
	abnormal retina morphology	J:71457
	abnormal retina photoreceptor layer morphology	J:71457
	abnormal retina pigment epithelium morphology	J:71457
	ataxia	J:45913
	brain vacuoles	J:45913
	dilated cardiomyopathy	J:45913
	hepatic steatosis	J:45913
	impaired righting response	J:45913
	postnatal growth retardation	J:45913
	postnatal lethality, complete penetrance	J:45913
	spongiform encephalopathy	J:45913
	thin retina inner nuclear layer	J:71457
	tremors	J:45913
Sod2tm1Cje/Sod2tm1Cje involves: C57BL/6J * CD-1	abnormal aerobic respiration	J:52592
	abnormal cell physiology	J:52592
	abnormal liver physiology	J:29899
	abnormal skeletal muscle morphology	J:29899
	abnormal tricarboxylic acid cycle	J:29899, J:52592
	calcinosis	J:29899
	cardiac fibrosis	J:29899
	cardiac hypertrophy	J:29899
	decreased body surface temperature	J:29899
	decreased circulating lactate level	J:29899
	decreased hematocrit	J:29899
	dilated cardiomyopathy	J:29899
	fatigue	J:29899
	hepatic steatosis	J:29899
	hypotonia	J:29899
	increased circulating ketone body level	J:29899
	increased liver weight	J:29899
	metabolic acidosis	J:29899
	organic aciduria	J:52592
	pallor	J:29899
	postnatal growth retardation	J:29899
	postnatal lethality, complete penetrance	J:29899
Sod2tm1Cje/Sod2tm1Cje involves: C57BL/6J * DBA/2J	abnormal blood homeostasis	J:73998
	abnormal blood pH regulation	J:73998
	abnormal brain morphology	J:98007
	abnormal brainstem morphology	J:98007
	abnormal enzyme/coenzyme level	J:73998
	abnormal forebrain morphology	J:98007
	abnormal frontal lobe morphology	J:98007
	abnormal gait	J:98007
	abnormal hippocampus morphology	J:98007
	abnormal skeletal muscle fiber morphology	J:98007
	abnormal thalamus morphology	J:98007
	abnormal tricarboxylic acid cycle	J:73998, J:98007
	abnormal trigeminal motor nucleus morphology	J:98007
	abnormal trigeminal V mesencephalic nucleus morphology	J:98007
	abnormal urine homeostasis	J:73998
	acidosis	J:73998
	ataxia	J:73998, J:98007
	axon degeneration	J:98007
	cardiac hypertrophy	J:73998
	decreased body weight	J:73998
	decreased circulating glucose level	J:73998
	decreased skeletal muscle fiber size	J:98007
	hyperoxia	J:73998
	hypocapnia	J:73998
	increased blood urea nitrogen level	J:73998
	increased circulating ketone body level	J:73998
	increased heart weight	J:73998
	normal liver/biliary system phenotype	J:73998
	neuron degeneration	J:98007
	postnatal lethality, complete penetrance	J:73998
	seizures	J:73998, J:98007
	tremors	J:98007
Sod2tm1Kskk/Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl/0 B6.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl	decreased a-wave amplitude	J:282248
	decreased b-wave amplitude	J:282248
	retina degeneration	J:282248
	retina pigment epithelium atrophy	J:282248
	thin retina outer nuclear layer	J:282248
Sod2tm1Kskk/Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl/0 B6J.Cg-Sod2tm1Kskk Tg(BEST1-rtTA,tetO-cre)1Yzl	abnormal Bruch membrane morphology	J:230153
	abnormal cone electrophysiology	J:230153
	abnormal ocular fundus morphology	J:230153
	abnormal optic choroid morphology	J:230153
	abnormal retina photoreceptor layer morphology	J:230153
	abnormal retina pigment epithelium morphology	J:230153
	abnormal retina pigmentation	J:230153
	abnormal retina rod cell outer segment morphology	J:230153
	abnormal retina vasculature morphology	J:230153
	abnormal rod electrophysiology	J:230153
	oxidative stress	J:230153
	retina hemorrhage	J:230153
	retina photoreceptor degeneration	J:230153
	retina pigment epithelium atrophy	J:230153
	short photoreceptor inner segment	J:230153
	short photoreceptor outer segment	J:230153
	thin retina outer nuclear layer	J:230153
Sod2tm1Leb/Sod2+ B6.129S7-Sod2tm1Leb/J	normal hearing/vestibular/ear phenotype	J:119972
Sod2tm1Leb/Sod2tm1Leb B6.129S7-Sod2tm1Leb/J	abnormal hepatocyte morphology	J:36148
	abnormal lipid homeostasis	J:36148
	abnormal mitochondrial physiology	J:36148
	abnormal motor capabilities/coordination/movement	J:36148
	anemia	J:36148
	circling	J:36148
	decreased body length	J:36148
	decreased body size	J:36148
	decreased body weight	J:36148
	decreased bone marrow cell number	J:36148
	decreased skeletal muscle mass	J:36148
	decreased total body fat amount	J:36148
	dilated cardiomyopathy	J:36148
	fatigue	J:36148
	impaired myelopoiesis	J:36148
	neurodegeneration	J:36148
	pallor	J:36148
	postnatal growth retardation	J:36148
	postnatal lethality, complete penetrance	J:36148
	normal reproductive system phenotype	J:64299
	thin ventricular wall	J:36148
	weakness	J:36148
Sod2tm1Shs/Sod2+ Tg(Cdh16-cre)91Igr/0 involves: C57BL/6 * C57BL/6CrSlc	abnormal renal tubule epithelium morphology	J:174099
	oxidative stress	J:174099
Sod2tm1Shs/Sod2tm1Shs involves: C57BL/6 * DBA	normal liver/biliary system phenotype	J:78889
Sod2tm1Shs/Sod2tm1Shs Tg(CAG-cre)13Miya/0 involves: C57BL/6 * C57BL/6CrSlc	perinatal lethality, complete penetrance	J:78889
Sod2tm1Shs/Sod2tm1Shs Tg(Cdh16-cre)91Igr/0 involves: C57BL/6 * C57BL/6CrSlc	abnormal renal tubule epithelium morphology	J:174099
	normal cardiovascular system phenotype	J:174099
	decreased body weight	J:174099
	dilated distal convoluted tubule	J:174099
	normal homeostasis/metabolism phenotype	J:174099
	normal mortality/aging	J:174099
	oxidative stress	J:174099
	renal cast	J:174099
	normal renal/urinary system phenotype	J:174099
Sod2tm1Shs/Sod2tm1Shs Tg(Ckmm-cre)5Khn/0 involves: C57BL/6CrSlc * FVB	abnormal cardiac muscle tissue morphology	J:117386
	abnormal heart echocardiography feature	J:117386
	abnormal heart left ventricle morphology	J:117386
	abnormal mitochondrial ATP synthesis coupled electron transport	J:117386
	abnormal mitochondrial crista morphology	J:117386
	abnormal myocardium layer morphology	J:117386
	abnormal oxidative phosphorylation	J:117386
	abnormal skeletal muscle morphology	J:117386
	cardiac interstitial fibrosis	J:117386
	cardiac muscle necrosis	J:117386
	congestive heart failure	J:117386
	decreased body weight	J:117386
	decreased cardiac muscle contractility	J:117386
	decreased food intake	J:117386
	decreased locomotor activity	J:117386
	decreased mitochondrial size	J:117386
	dilated cardiomyopathy	J:117386
	dilated heart left ventricle	J:117386
	dilated heart ventricle	J:117386
	enlarged heart	J:117386
	fatigue	J:117386
	increased cardiac muscle glycogen level	J:117386
	increased heart weight	J:117386
	myocardial fiber degeneration	J:117386
	oxidative stress	J:117386
	postnatal growth retardation	J:117386
	premature death	J:117386
Sod2tm1Shs/Sod2tm1Shs Tg(Ckmm-cre)5Khn/0 involves: FVB	abnormal enzyme/coenzyme activity	J:171017
	abnormal heart echocardiography feature	J:171017
	cardiac interstitial fibrosis	J:171017
	dilated cardiomyopathy	J:171017
	dilated heart	J:171017
	dilated heart left ventricle	J:171017
	increased heart weight	J:171017
	myocardial fiber degeneration	J:171017
	myocardial fiber disarray	J:171017
	oxidative stress	J:171017
Sod2tm1Shs/Sod2tm1Shs Tg(TNNI2-icre)1Vrmn/0 involves: C57BL/6	abnormal enzyme/coenzyme activity	J:155917
	abnormal enzyme/coenzyme level	J:155917
	abnormal mitochondrial physiology	J:155917
	abnormal muscle contractility	J:155917
	abnormal muscle physiology	J:155917
	abnormal skeletal muscle fiber mitochondrial morphology	J:155917
	abnormal skeletal muscle morphology	J:155917
	abnormal tibialis anterior morphology	J:155917
	normal adipose tissue phenotype	J:155917
	decreased aerobic running capacity	J:155917
	normal growth/size/body region phenotype	J:155917
	normal homeostasis/metabolism phenotype	J:155917
	impaired exercise endurance	J:155917
	increased muscle cell glucose uptake	J:155917
	increased muscle fatigability	J:155917
	normal muscle phenotype	J:155917
Sod2tm1Smel/Sod2tm1Smel Tg(KRT14-cre/ERT)20Efu/0 involves: C57BL/6J * CD-1	abnormal epidermis stratum corneum morphology	J:226565
	abnormal keratinocyte differentiation	J:226565
	abnormal mitochondrial ATP synthesis coupled electron transport	J:226565
	decreased epidermal stem cell number	J:226565
	decreased keratinocyte proliferation	J:226565
	delayed wound healing	J:226565
	early cellular replicative senescence	J:226565
	enhanced wound healing	J:226565
	skin lesions	J:226565
	thick epidermis	J:226565
	thin epidermis	J:226565