Tg(TNNI2-icre)1Vrmn
Transgene Detail

Summary

• Symbol: Tg(TNNI2-icre)1Vrmn
• Name: transgene insertion 1, Holly Van Remmen
• MGI ID: MGI:4418328
• Synonyms: TnIFastCre
• Transgene: Tg(TNNI2-icre)1Vrmn Location: unknown
• Alliance: Tg(TNNI2-icre)1Vrmn page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(TNNI2-icre)1Vrmn expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	TNNI2

• Mutation details: The transgene construct included 530 bp of 5'-flanking quail TnIFast (TNNI2) gene sequence (promter), exon 1, intron 1 containing the IRE-enhancer, and the untranslated exon 2 sequence up to the ATG initiation codon. The improved cre (icre) coding sequence replaced exon 2 sequences downstream of the ATG and was linked to the SV40 splicing and polyadenylation signals. (J:155917)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	TNNI2 (species not specified) Summary of all recombinase alleles driven by TNNI2.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:155917 Lustgarten MS, et al., Conditional knockout of Mn-SOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity. Am J Physiol Cell Physiol. 2009 Dec;297(6):C1520-32
• All: 2 reference(s)