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Symbol
Name
ID
Sod2
superoxide dismutase 2, mitochondrial
MGI:98352
Phenotype annotations related to muscle
*Aspects of the system are reported to show a normal phenotype.
!Indicates phenotype varies with strain background.
Darker colors indicate more annotations
Human Phenotypes
Quadriceps muscle weakness
Spasticity
EMG abnormality
Distal muscle weakness
Generalized muscle weakness
Proximal muscle weakness
Abnormal muscle fiber morphology
Ragged-red muscle fibers
Rimmed vacuoles
Skeletal muscle atrophy
Myopathy
Inflammatory myopathy
Disease(s) Associated with SOD2
inclusion body myositis
Leber hereditary optic neuropathy
multiple myeloma
neuronal ceroid lipofuscinosis

Mouse Phenotypes
muscle phenotype
abnormal cardiac muscle tissue morphology
increased cardiac muscle glycogen level
abnormal myocardium layer morphology
abnormal myocardial fiber morphology
myocardial fiber degeneration
myocardial fiber disarray
cardiac muscle necrosis
dilated cardiomyopathy
decreased cardiac muscle contractility
increased cardiomyocyte apoptosis
abnormal skeletal muscle fiber mitochondrial morphology
increased muscle cell glucose uptake
abnormal tibialis anterior morphology
abnormal skeletal muscle fiber morphology
decreased skeletal muscle fiber size
abnormal skeletal muscle morphology
decreased skeletal muscle mass
abnormal muscle physiology
abnormal muscle contractility
hypotonia
increased muscle fatigability
Availability Mouse Genotype
Sod2tm1.1Kskk/Sod2tm1.1Kskk
Sod2tm1Cje/Sod2tm1Cje !
Sod2tm1Leb/Sod2tm1Leb
Sod2tm1.1Kskk/Sod2+
Sod2tm1Shs/Sod2tm1Shs
Tg(TNNI2-icre)1Vrmn/0  (conditional)
*
Sod2tm1Shs/Sod2tm1Shs
Tg(Ckmm-cre)5Khn/0  (conditional)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory