Symbol
Name
ID

Sod2
superoxide dismutase 2, mitochondrial
MGI:98352

Phenotype annotations related to cellular

Darker colors indicate more annotations

Human Phenotypes	Increased circulating IgA level	Increased circulating IgG level	Decreased circulating antibody level	Paraproteinemia	Intracellular accumulation of autofluorescent lipopigment storage material	Fingerprint intracellular accumulation of autofluorescent lipopigment storage material
Disease(s) Associated with SOD2	Increased circulating IgA level	Increased circulating IgG level	Decreased circulating antibody level	Paraproteinemia
multiple myeloma
neuronal ceroid lipofuscinosis

Mouse Phenotypes

cardiac muscle necrosis

cardiac interstitial fibrosis

increased cardiomyocyte apoptosis

abnormal mitochondrial crista morphology

abnormal skeletal muscle fiber mitochondrial morphology

decreased mitochondrial size

abnormal cell physiology

increased hepatocyte apoptosis

abnormal keratinocyte differentiation

decreased keratinocyte proliferation

increased muscle cell glucose uptake

early cellular replicative senescence

abnormal aerobic respiration

abnormal tricarboxylic acid cycle

abnormal respiratory electron transport chain

abnormal mitochondrial ATP synthesis coupled electron transport

abnormal mitochondrial physiology

abnormal oxidative phosphorylation

oxidative stress

Availability

Mouse Genotype

Sod2^tm1.1Kskk/Sod2^tm1.1Kskk

Sod2^tm1Cje/Sod2^tm1Cje

Sod2^tm1Leb/Sod2^tm1Leb

Sod2^tm1.1Kskk/Sod2⁺

Sod2^tm1Cje/Sod2⁺

Sod2^tm1Kskk/Sod2^tm1Kskk
Tg(BEST1-rtTA,tetO-cre)1Yzl/0 (conditional)

Sod2^tm1Shs/Sod2^tm1Shs
Tg(TNNI2-icre)1Vrmn/0 (conditional)

Sod2^tm1Shs/Sod2^tm1Shs
Tg(Cdh16-cre)91Igr/0 (conditional)

Sod2^tm1Shs/Sod2^tm1Shs
Tg(Ckmm-cre)5Khn/0 (conditional)

Sod2^tm1Smel/Sod2^tm1Smel
Tg(KRT14-cre/ERT)20Efu/0 (conditional)

Sod2^tm1Shs/Sod2⁺
Tg(Cdh16-cre)91Igr/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23