Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables superoxide dismutase activity. Acts upstream of or within several processes, including acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure; apoptotic signaling pathway; and regulation of cellular biosynthetic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Used to study Canavan disease; Leigh disease; amyotrophic lateral sclerosis type 1; congestive heart failure; and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); cardiomyopathy (multiple); liver disease (multiple); and optic nerve disease (multiple). Orthologous to human SOD2 (superoxide dismutase 2).
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