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Gstm1 Gene Detail
Summary
  • Symbol
    Gstm1
  • Name
    glutathione S-transferase, mu 1
  • Synonyms
    Gstb1, Gstb-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95860
    NCBI Gene: 14862
Location & Maps
more
  • Sequence Map
    Chr3:108012255-108017973 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5719 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 46.83 cM, cytoband F3
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    GSTM5, glutathione S-transferase mu 5
  • Vertebrate Orthologs
    5
  • Human Ortholog
    GSTM5, glutathione S-transferase mu 5
    Orthology source: HomoloGene
  • Synonyms
    GSTM5-5, GTM5
  • Links
    NCBI Gene ID: 2949
    neXtProt AC: NX_P46439

  • Chr Location
    1p13.3; chr1:109711761-109718268 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Gstm1 mouse models

Human Disease Mouse Models
       Autism   OMIM: 209850 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Gstm1
  • Incidental Mutations
Mice homozygous for the deletion of this gene display a reduced ability to metabolize 1,2-dichloro-4-nitrobenzene. Mice homozygous for a different knock-out allele exhibit abnormal behavior, altered response to valproic acid, and increased serotonin and dopamine levels in the cerebellum.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007188 VEGA Gene Model | MGI Sequence Detail 5719 C57BL/6J ±  kb
transcript OTTMUST00000016593 VEGA | MGI Sequence Detail 828 Not Applicable  
polypeptide OTTMUSP00000007630 VEGA | MGI Sequence Detail 244 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    108 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • EC
  • InterPro Domains
    IPR004046 Glutathione S-transferase, C-terminal
    IPR010987 Glutathione S-transferase, C-terminal-like
    IPR003081 Glutathione S-transferase, Mu class
    IPR004045 Glutathione S-transferase, N-terminal
    IPR012336 Thioredoxin-like fold
Molecular
Reagents
less
  • All nucleic 19
    Genomic 5
    cDNA 11
    Primer pair 3

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-10314, MGD-MRK-10318
References
more
  • Summaries
    All 39
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 8
    Phenotypes 6
  • Earliest
    J:9365 Pearson WR, et al., Tissue-specific induction of murine glutathione transferase mRNAs by butylated hydroxyanisole. J Biol Chem. 1988 Sep 15;263(26):13324-32
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory