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Gstm1
Gene Detail
Symbol

Name
ID
Gstm1
glutathione S-transferase, mu 1
MGI:95860
Synonyms
Gstb1, Gstb-1
Feature Type
protein coding gene
Genetic Map
Chromosome 3
46.83 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:108012255-108017973 bp, - strand
From VEGA annotation of GRCm38

  5719 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:115474  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque

HCOP human homology predictions: GSTM5
Gene Tree: Gstm1

Human
homologs
GSTM5, glutathione S-transferase mu 5
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2949
neXtProt AC: NX_P46439

Human Synonyms: GSTM5-5, GTM5

Human Chr (Location): 1p13.3; chr1:109711761-109718268 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for the deletion of this gene display a reduced ability to metabolize 1,2-dichloro-4-nitrobenzene. Mice homozygous for a different knock-out allele exhibit abnormal behavior, altered response to valproic acid, and increased serotonin and dopamine levels in the cerebellum.
 
Human Diseases Modeled in Mice Using Gstm1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Gstm1 interacts with 41 markers (Mir26a-1, Mir26a-2, Mir26b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process cellular response to drug, glutathione metabolic process, ...
Component cytoplasm, extracellular region, ...
Function glutathione transferase activity, nickel cation binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (299)    Tissues (117)    Images (56)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 285
RT-PCR 14
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gstm1    NEW 
Molecular
reagents
All nucleic(19) Genomic(5) cDNA(11) Primer pair(3)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000007188 (Evidence)
Ensembl Gene Model ENSMUSG00000058135 (Evidence)
Entrez Gene 14862 (Evidence)
DFCI TC1573130
DoTS DT.101207421, DT.496856
NIA Mouse Gene Index U120466, U024510
EC 2.5.1.18
Consensus CDS Project CCDS17747.1
International Mouse Phenotyping Consortium Status Gstm1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007188 VEGA Gene Model | MGI Sequence Detail 5719 C57BL/6J ±  kb
transcript OTTMUST00000016591 VEGA | MGI Sequence Detail 1289 Not Applicable 
polypeptide OTTMUSP00000007628 VEGA | MGI Sequence Detail 218 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(118 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004046 Glutathione S-transferase, C-terminal
InterPro IPR010987 Glutathione S-transferase, C-terminal-like
InterPro IPR003081 Glutathione S-transferase, Mu class
InterPro IPR004045 Glutathione S-transferase, N-terminal
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000008300 glutathione S-transferase Mu 1
References
(Earliest) J:9365 Pearson WR, et al., Tissue-specific induction of murine glutathione transferase mRNAs by butylated hydroxyanisole. J Biol Chem. 1988 Sep 15;263(26):13324-32
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(43)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-10314, MGD-MRK-10318

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory