Gstm1
Gene Detail

Symbol Name ID

Gstm1 glutathione S-transferase, mu 1 MGI:95860

Synonyms

Gstb1, Gstb-1

Feature Type

protein coding gene

Genetic Map

Chromosome 3

46.83 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr3:108012255-108017973 bp, - strand From VEGA annotation of GRCm38   5719 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:115474  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque

Gene Tree: Gstm1

Human homologs

Human Homolog		GSTM5, glutathione S-transferase mu 5
NCBI Gene ID		2949
neXtProt AC		NX_P46439
Human Synonyms		GSTM5-5, GTM5
Human Chr (Location)		1p13.3; chr1:110254864-110260890 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for the deletion of this gene display a reduced ability to metabolize 1,2-dichloro-4-nitrobenzene. Mice homozygous for a different knock-out allele exhibit abnormal behavior, altered response to valproic acid, and increased serotonin and dopamine levels in the cerebellum.

 
Human Diseases Modeled Using Mouse Gstm1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	cellular response to drug, glutathione metabolic process, ...
Component	extracellular region, protein complex
Function	glutathione transferase activity, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (299)    Tissues (117)    Images (56)
Theiler Stages: 11, 21, 22, 23

Assay Type	Results
RNA in situ	285
RT-PCR	14

cDNA source data(527)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(535) Genomic(5) cDNA(527) Primer pair(3)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000007188 (Evidence)
Ensembl Gene Model	ENSMUSG00000058135 (Evidence)
Entrez Gene	14862 (Evidence)
UniGene	37199
DFCI	TC1573130
DoTS	DT.101207421, DT.496856
NIA Mouse Gene Index	U024510, U120466
EC	2.5.1.18
Consensus CDS Project	CCDS17747.1
International Mouse Knockout Project Status	Gstm1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000007188	VEGA Gene Model | MGI Sequence Detail	5719	C57BL/6J
transcript	OTTMUST00000016591	VEGA | MGI Sequence Detail	1289	Not Applicable
polypeptide	OTTMUSP00000007628	VEGA | MGI Sequence Detail	218	Not Applicable

All sequences(39) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(102 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017933	Glutathione S-transferase/chloride channel, C-terminal
InterPro	IPR004046	Glutathione S-transferase, C-terminal
InterPro	IPR010987	Glutathione S-transferase, C-terminal-like
InterPro	IPR003081	Glutathione S-transferase, Mu class
InterPro	IPR004045	Glutathione S-transferase, N-terminal
InterPro	IPR012336	Thioredoxin-like fold
Protein Ontology	PR:000008300	glutathione S-transferase Mu 1

References

(Earliest) J:9365 Pearson WR, et al., Tissue-specific induction of murine glutathione transferase mRNAs by butylated hydroxyanisole. J Biol Chem. 1988 Sep 15;263(26):13324-32
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(44)

Other accession IDs

MGD-MRK-10314, MGD-MRK-10318