About   Help   FAQ
Brca2
Gene Detail
 Symbol
Name
ID
Brca2
breast cancer 2
MGI:109337
Synonyms Fancd1, RAB163
Feature Type protein coding gene
Genetic Map
Chromosome 5
89.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr5:150522630-150569746 bp, + strand
From Ensembl annotation of GRCm38

  47117 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:41  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: DNA recombination repair protein, BRCA2 type
Gene Tree: Brca2

Human
homologs
Human Homolog BRCA2, breast cancer 2, early onset
NCBI Gene ID 675
neXtProt AC  NX_P51587
Human Synonyms  BRCC2, BROVCA2, FACD, FAD, FAD1, FANCD, FANCD1, GLM3, PNCA2
Human Chr (Location)  13q12.3; chr13:32315480-32399672 (+)  GRCh38
Disease Associations  (8) Diseases Associated with Human BRCA2
Mutations,
alleles, and
phenotypes
All mutations/alleles(53) : Gene trapped(36) Targeted(17)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mutants are embryonic lethal with abnormalities including growth retardation, neural tube defects, and mesoderm abnormalities; conditional mutations cause genetic instability and enhanced tumor formation; mutants with truncated BRCA2 protein survive, are small, infertile, show improper tissue differentiation and develop lymphomas and carcinomas.
 
Human Diseases Modeled Using Mouse Brca2 (5)    Alleles Annotated to Human Diseases(7)   
Interactions
Brca2 interacts with 219 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (75 annotations)
Process brain development, cell aging, ...
Component BRCA2-MAGE-D1 complex, centrosome, ...
Function DNA binding, gamma-tubulin binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (270)    Tissues (151)    Images (22)
Theiler Stages: 2, 3, 13, 15, 17, 19, 20, 21, 22, 23, 28
Assay TypeResults
RNA in situ 124
Northern blot 16
RT-PCR 130
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(43) Genomic(10) cDNA(26) Primer pair(7)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000041147 (Evidence)
Entrez Gene12190 (Evidence)
DFCITC1578283, TC1693182
DoTSDT.110704159, DT.110704169, DT.529022, DT.55281027, DT.94252366
NIA Mouse Gene IndexU006487
PDB1MIU, 1MJE
Consensus CDS ProjectCCDS39411.1
International Mouse Knockout Project StatusBrca2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041147 Ensembl Gene Model | MGI Sequence Detail 47117 C57BL/6J ±  kb
transcript ENSMUST00000044620 Ensembl | MGI Sequence Detail 10724 Not Applicable 
polypeptide ENSMUSP00000038576 Ensembl | MGI Sequence Detail 3329 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(11) UniProt(3)
Polymorphisms All PCR and RFLP(4) : PCR(2) RFLP(2) SNPs within 2kb(225 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015187 BRCA2, oligonucleotide/oligosaccharide-binding 1
InterPro IPR015188 BRCA2, oligonucleotide/oligosaccharide-binding 3
InterPro IPR002093 BRCA2 repeat
InterPro IPR015525 Breast cancer type 2 susceptibility protein
InterPro IPR015252 DNA recombination/repair protein BRCA2, helical domain
InterPro IPR012340 Nucleic acid-binding, OB-fold
InterPro IPR015205 Tower
Protein Ontology PR:000004804 breast cancer type 2 susceptibility protein
References (Earliest) J:36562 Rajan JV, et al., Brca2 is coordinately regulated with Brca1 during proliferation and differentiation in mammary epithelial cells. Proc Natl Acad Sci U S A. 1996 12;93(23):13078-83
(Latest) J:212979 Mundia MM, et al., Nascent DNA synthesis during homologous recombination is synergistically promoted by the rad51 recombinase and DNA homology. Genetics. 2014 May;197(1):107-19
All references(122)
Disease annotation references (4)
Other
accession IDs
MGD-MRK-38382, MGI:2140824, MGI:2141125

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/23/2014
MGI 5.19
The Jackson Laboratory