Homozygous null mutants are embryonic lethal with abnormalities including growth retardation, neural tube defects, and mesoderm abnormalities; conditional mutations cause genetic instability and enhanced tumor formation; mutants with truncated BRCA2 protein survive, are small, infertile, show improper tissue differentiation and develop lymphomas and carcinomas.
|InterPro||IPR015187||BRCA2, oligonucleotide/oligosaccharide-binding 1|
|InterPro||IPR015188||BRCA2, oligonucleotide/oligosaccharide-binding 3|
|InterPro||IPR015525||Breast cancer type 2 susceptibility protein|
|InterPro||IPR015252||DNA recombination/repair protein BRCA2, helical domain|
|InterPro||IPR012340||Nucleic acid-binding, OB-fold|
|Protein Ontology||PR:000004804||breast cancer type 2 susceptibility protein|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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