Phenotypes Associated with This Genotype

Genotype
MGI:3055719

• Allelic Composition: Brca2^tm1Mhun/Brca2⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased tumor incidence ( J:89083 )

• remain tumor free for over a year

decreased incidence of tumors by chemical induction ( J:89083 )

• delayed tumor development in response to medroxyprogesterone acetate as compared to controls

• predominantly mammary tumors

cellular

abnormal cell physiology ( J:89083 )

• mammary tumor cell lines grew significantly faster after the third day in culture

increased apoptosis ( J:89083 )

• very sensitive to DMBA induced apoptosis

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:89083 )

• delayed tumor development in response to medroxyprogesterone acetate as compared to controls

• predominantly mammary tumors

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
breast cancer		DOID:1612	OMIM:114480	J:89083