|
Symbol Name ID |
Brca2
breast cancer 2, early onset MGI:109337 |
| * | Aspects of the system are reported to show a normal phenotype. |
| Darker colors indicate more annotations |
| Human Phenotypes | Abnormality of chromosome stability |
Chromosomal breakage induced by crosslinking agents |
| Disease(s) Associated with BRCA2 | ||
| Fanconi anemia | ||
| Fanconi anemia complementation group D1 |
| Mouse Phenotypes | cellular phenotype |
azoospermia |
absent germ cells |
abnormal chromosome morphology |
aneuploidy |
abnormal cell physiology |
abnormal mitosis |
increased sensitivity to induced cell death |
increased T cell apoptosis |
increased apoptosis |
decreased fibroblast proliferation |
early cellular replicative senescence |
abnormal DNA repair |
abnormal double-strand DNA break repair |
chromosomal instability |
chromosome breakage |
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| Availability | Mouse Genotype | ||||||||||||||||
| Brca2tm1Cam/Brca2tm1Cam | |||||||||||||||||
| Brca2tm1Cbl/Brca2tm1Cbl | |||||||||||||||||
| Brca2tm1Kamc/Brca2tm1Kamc | |||||||||||||||||
| Brca2tm1Hst/Brca2tm2Hst | |||||||||||||||||
| Brca2tm1Mhun/Brca2+ | |||||||||||||||||
| Brca2tm1Brn/Brca2tm1Brn Cd19tm1(cre)Cgn/Cd19+ (conditional) |
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| Brca2tm1Mak/Brca2tm2Mak Tg(Lck-cre)548Jxm/0 (conditional) |
* | ||||||||||||||||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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