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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Brca2
breast cancer 2, early onset
MGI:109337
48 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
ApcMin/Apc+
Brca2tm1Mbn/Brca2+
B6.Cg-Brca2tm1Mbn ApcMin 		abnormal adrenal gland morphology J:67445
abnormal mammary gland development J:67445
abnormal ovarian follicle morphology J:67445
abnormal ovarian folliculogenesis J:67445
abnormal vagina epithelium morphology J:67445
absent corpus luteum J:67445
absent mature ovarian follicles J:67445
absent nipple J:67445
normal growth/size/body region phenotype J:67445
increased incidence of induced tumors J:67445
increased incidence of tumors by chemical induction J:67445
increased mammary gland tumor incidence J:67445
ovary atrophy J:67445
normal reproductive system phenotype J:67445
uterus atrophy J:67445
Brca1tm1Arge/Brca1tm1Arge
Brca2tm1Arge/Brca2tm1Arge
involves: 129S/SvEv * C57BL/6 		abnormal embryonic tissue morphology J:40594
embryonic lethality, complete penetrance J:40594
Brca2tm1Arge/Brca2tm1Arge
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 		abnormal embryonic tissue morphology J:40594
exencephaly J:40594
prenatal lethality J:40594
Brca2tm1Brn/Brca2+
Trp53tm1Brn/Trp53tm1Brn
Tg(KRT14-cre)8Brn/0
involves: 129P2/OlaHsd * FVB/N 		increased mammary adenocarcinoma incidence J:73028
increased mammary gland tumor incidence J:73028
increased skin tumor incidence J:73028
increased tumor incidence J:73028
Brca2tm1Brn/Brca2tm1Brn
Ptch1tm1Mps/Ptch1+
Trp53tm1Tyj/Trp53+
Tg(Nes-cre)1Kln/0
involves: 129 * C57BL/6 * SJL 		increased medulloblastoma incidence J:144617
Brca2tm1Brn/Brca2tm1Brn
Ptch1tm1Mps/Ptch1+
Trp53tm1Tyj/Trp53tm1Tyj
Tg(Nes-cre)1Kln/0
involves: 129 * C57BL/6 * SJL 		increased medulloblastoma incidence J:144617
Brca2tm1Brn/Brca2tm1Brn
Tg(Krt18-EGFP,-TAg121)36Ysng/0
Trp53tm1Brn/Trp53tm2Tyj
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N 		increased ovary tumor incidence J:189304
Brca2tm1Brn/Brca2tm1Brn
Trp53tm1Brn/Trp53+
Tg(KRT14-cre)8Brn/0
involves: 129P2/OlaHsd * FVB/N 		increased mammary adenocarcinoma incidence J:73028
increased mammary gland tumor incidence J:73028
increased skin tumor incidence J:73028
increased tumor incidence J:73028
Brca2tm1Brn/Brca2tm1Brn
Trp53tm1Brn/Trp53+
Tg(Pbsn-cre)4Prb/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal prostate gland morphology J:161511
abnormal prostate gland physiology J:161511
increased prostate intraepithelial neoplasia incidence J:161511
Brca2tm1Brn/Brca2tm1Brn
Trp53tm1Brn/Trp53tm1Brn
Tg(KRT14-cre)8Brn/0
involves: 129P2/OlaHsd * FVB/N 		increased mammary adenocarcinoma incidence J:73028
increased mammary gland tumor incidence J:73028
increased skin tumor incidence J:73028
increased tumor incidence J:73028
Brca2tm1Brn/Brca2tm1Brn
Trp53tm1Brn/Trp53tm1Brn
Tg(Pbsn-cre)4Prb/0
involves: 129P2/OlaHsd * C57BL/6 * DBA/2 		abnormal prostate gland physiology J:161511
increased prostate intraepithelial neoplasia incidence J:161511
prostate gland hyperplasia J:161511
Brca2tm1Brn/Brca2tm1Brn
Trp53tm1Tyj/Trp53+
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL 		abnormal tumor morphology J:144617
increased medulloblastoma incidence J:144617
Brca2tm1Brn/Brca2tm1Brn
Trp53tm1Tyj/Trp53tm1Tyj
Tg(Nes-cre)1Kln/0
involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * SJL 		increased medulloblastoma incidence J:144617
Brca2tm1Brn/Brca2tm1Brn
Trp53bp1tm1Jc/Trp53bp1tm1Jc
Cd19tm1(cre)Cgn/Cd19+
involves: 129P2/OlaHsd 		chromosome breakage J:197442
Brca2tm1Brn/Brca2tm1Cam
Krastm4Tyj/Kras+
Trp53tm3Tyj/Trp53+
Tg(Pdx1-cre)6Tuv/0
involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N 		increased pancreatic acinar cell carcinoma incidence J:166678
increased pancreatic ductal adenocarcinoma incidence J:166678
premature death J:166678
Brca2tm1Cam/Brca2+
Krastm4Tyj/Kras+
Tg(Pdx1-cre)6Tuv/0
involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N 		increased pancreatic ductal adenocarcinoma incidence J:166678
premature death J:166678
Brca2tm1Cam/Brca2+
Krastm4Tyj/Kras+
Trp53tm3Tyj/Trp53+
Tg(Pdx1-cre)6Tuv/0
involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N 		increased pancreatic ductal adenocarcinoma incidence J:166678
premature death J:166678
Brca2tm1Cam/Brca2tm1Brn
Krastm4Tyj/Kras+
Tg(Pdx1-cre)6Tuv/0
involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N 		exocrine pancreatic insufficiency J:166678
increased pancreas apoptosis J:166678
increased pancreatic ductal adenocarcinoma incidence J:166678
premature death J:166678
Brca2tm1Cam/Brca2tm1Brn
Tg(Pdx1-cre)6Tuv/0
Trp53tm3Tyj/Trp53+
involves: 129P2/OlaHsd * 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N 		exocrine pancreatic insufficiency J:166678
increased malignant tumor incidence J:166678
increased sarcoma incidence J:166678
premature death J:166678
Brca2tm1Kamc/Brca2tm1Kamc
Swsap1em1Mjn/Swsap1em1Mjn
involves: 129P2/OlaHsd * C57BL/6J * CBA/J 		abnormal chromosomal synapsis J:268570
arrest of male meiosis J:268570
decreased testis weight J:268570
Brca2tm1Kamc/Brca2tm1Kamc
Trp53tm1Tyj/Trp53+
involves: 129P2/OlaHsd * 129S2/SvPas * BALB/c * C57BL/6 		decreased survivor rate J:109193
increased mammary gland tumor incidence J:109193
increased osteosarcoma incidence J:109193
increased stomach tumor incidence J:109193
Brca2tm1Mak/Brca2tm2Mak
Trp53tm1Brd/Trp53tm1Brd
Tg(Lck-cre)548Jxm/0
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CBA 		abnormal chromosome morphology J:79697
decreased cellular sensitivity to ionizing radiation J:79697
normal immune system phenotype J:79697
increased activated T cell number J:79697
increased lymphoma incidence J:79697
increased malignant tumor incidence J:79697
increased osteosarcoma incidence J:79697
increased tumor incidence J:79697
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/30/2024
MGI 6.23 		The Jackson Laboratory