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Lep Gene Detail
Summary
  • Symbol
    Lep
  • Name
    leptin
  • Feature Type
    protein coding gene
  • IDs
    MGI:104663
    NCBI Gene: 16846
  • Gene Overview
    MyGene.info: LEP
Location & Maps
more
  • Sequence Map
    Chr6:29060220-29073877 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13658 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 12.30 cM
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    LEP, leptin
  • Vertebrate Orthologs
    8
  • Human Ortholog
    LEP, leptin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LEPD, OB, OBS
  • Links
    NCBI Gene ID: 3952
    neXtProt AC: NX_P41159

  • Chr Location
    7q31.3; chr7:128241202-128257629 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 193
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 frog, western clawed
  • HCOP
    human homology predictions: LEP
  • Protein SuperFamily
  • Gene Tree
    Lep
Human Diseases
more
  • Diseases
    3 with Lep mouse models; 1 with human LEP associations

Human Disease Mouse Models
       Abdominal Obesity-Metabolic Syndrome 1; AOMS1   OMIM: 605552 View 1 model
Diabetes Mellitus, Noninsulin-Dependent; NIDDM   OMIM: 125853 View 1 model
Obesity   OMIM: 601665 View 3 models
       Leptin Deficiency or Dysfunction; LEPD   OMIM: 614962
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    25 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    204 phenotypes from 8 alleles in 24 genetic backgrounds
    173 phenotypes from multigenic genotypes
    5 images
    998 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (ENU)
    3
  • Spontaneous
    2
  • Targeted
    6
  • Transgenic
    3
  • Incidental Mutations
Homozygotes are obese, hyperphagic, have low activity, high metabolic efficiency, impaired thermogenesis, infertility and short lifespan in addition to varying other abnormalities. Strain background affects severity and course of diabetes. Heterozygotes survive fasting longer than control mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035815 VEGA Gene Model | MGI Sequence Detail 13658 C57BL/6J ±  kb
transcript OTTMUST00000091731 VEGA | MGI Sequence Detail 3259 Not Applicable  
polypeptide OTTMUSP00000050551 VEGA | MGI Sequence Detail 167 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    140 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 51
    Genomic 12
    cDNA 34
    Primer pair 5

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-12967, MGD-MRK-26103
References
more
  • Summaries
    All 1261
    Developmental Gene Expression 13
    Diseases 25
    Gene Ontology 34
    Phenotypes 998
  • Earliest
    J:13066 INGALLS AM, et al., Obese, a new mutation in the house mouse. J Hered. 1950 Dec;41(12):317-8
  • Latest
    J:234498 Romere C, et al., Asprosin, a Fasting-Induced Glucogenic Protein Hormone. Cell. 2016 Apr 21;165(3):566-79

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory