Lep
Gene Detail

Symbol Name ID

Lep leptin MGI:104663

Feature Type

protein coding gene

Genetic Map

Chromosome 6

12.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr6:29060220-29073877 bp, + strand From VEGA annotation of GRCm38   13658 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:193  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: leptin
Gene Tree: Lep

Human homologs

Human Homolog		LEP, leptin
NCBI Gene ID		3952
neXtProt AC		NX_P41159
Human Synonyms		LEPD, OB, OBS
Human Chr (Location)		7q31.3; chr7:127881331-127897682 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human LEP

Alleles and phenotypes

All alleles(7) : Targeted(3) Spontaneous(2) Chemically induced(2)
 

Homozygotes are obese, hyperphagic, have low activity, high metabolic efficiency, impaired thermogenesis, infertility and short lifespan in addition to varying other abnormalities. Strain background affects severity and course of diabetes. Heterozygotes survive fasting longer than control mice.

 
Human Diseases Modeled Using Mouse Lep (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (65 annotations)

Process	adipose tissue development, adult feeding behavior, ...
Component	extracellular region, extracellular space
Function	growth factor activity, hormone activity, ...

External Resources: FuncBase

Expression

Literature Summary: (13 records)
Data Summary: Results (91)    Tissues (53)    Images (19)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	28
Northern blot	17
RT-PCR	46

cDNA source data(31)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(51) Genomic(12) cDNA(34) Primer pair(5)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000035815 (Evidence)
Ensembl Gene Model	ENSMUSG00000059201 (Evidence)
Entrez Gene	16846 (Evidence)
UniGene	277072
DFCI	TC1586285, TC1618163
DoTS	DT.491758
NIA Mouse Gene Index	U006609
Consensus CDS Project	CCDS19955.1
International Mouse Knockout Project Status	Lep

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035815	VEGA Gene Model | MGI Sequence Detail	13658	C57BL/6J
transcript	OTTMUST00000091731	VEGA | MGI Sequence Detail	3259	Not Applicable
polypeptide	OTTMUSP00000050551	VEGA | MGI Sequence Detail	167	Not Applicable

All sequences(30) RefSeq(2) UniProt(4)

Polymorphisms

All PCR and RFLP(5) : PCR(4) RFLP(1) SNPs(116 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR012351	Four-helical cytokine, core
InterPro	IPR009079	Four-helical cytokine-like, core
InterPro	IPR000065	Obesity factor
Protein Ontology	PR:000009758	leptin

References

(Earliest) J:13066 INGALLS AM, et al., Obese, a new mutation in the house mouse. J Hered. 1950 Dec;41(12):317-8
(Latest) J:195073 Arteaga-Solis E, et al., Inhibition of leptin regulation of parasympathetic signaling as a cause of extreme body weight-associated asthma. Cell Metab. 2013 Jan 8;17(1):35-48
All references(1017)

Other accession IDs

MGD-MRK-12967, MGD-MRK-26103