About   Help   FAQ
Lep
Gene Detail
Symbol

Name
ID
Lep
leptin
MGI:104663
Feature Type
protein coding gene
Genetic Map
Chromosome 6
12.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr6:29060220-29073877 bp, + strand
From VEGA annotation of GRCm38

  13658 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:193  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: LEP
Protein SuperFamily: leptin
Gene Tree: Lep

Human
homologs
LEP, leptin
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3952
neXtProt AC: NX_P41159

Human Synonyms: LEPD, OB, OBS

Human Chr (Location): 7q31.3; chr7:128241202-128257629 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LEP

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Chemically induced (ENU)(2) Spontaneous(2) Targeted(4) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes are obese, hyperphagic, have low activity, high metabolic efficiency, impaired thermogenesis, infertility and short lifespan in addition to varying other abnormalities. Strain background affects severity and course of diabetes. Heterozygotes survive fasting longer than control mice.
 
Human Diseases Modeled in Mice Using Lep (2)    Mutations Annotated to Human Diseases (2)    Phenotype Images(2)
Interactions
Lep interacts with 264 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (74 annotations)
Process adipose tissue development, adult feeding behavior, ...
Component cell, cytoplasm, ...
Function growth factor activity, hormone activity, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (91)    Tissues (53)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 28
Northern blot 17
RT-PCR 46
cDNA source data(31)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lep ; ZFIN lepa, lepb    NEW 
Molecular
reagents
All nucleic(51) Genomic(12) cDNA(34) Primer pair(5)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000035815 (Evidence)
Ensembl Gene Model ENSMUSG00000059201 (Evidence)
Entrez Gene 16846 (Evidence)
UniGene 277072
DFCI TC1586285, TC1618163
DoTS DT.491758
NIA Mouse Gene Index U006609
Consensus CDS Project CCDS19955.1
International Mouse Phenotyping Consortium Status Lep
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035815 VEGA Gene Model | MGI Sequence Detail 13658 C57BL/6J ±  kb
transcript OTTMUST00000091731 VEGA | MGI Sequence Detail 3259 Not Applicable 
polypeptide OTTMUSP00000050551 VEGA | MGI Sequence Detail 167 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(4) UniProt(4)
Polymorphisms
All PCR and RFLP(5) : PCR(4) RFLP(1) SNPs within 2kb(140 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012351 Four-helical cytokine, core
InterPro IPR009079 Four-helical cytokine-like, core
InterPro IPR000065 Obesity factor
Protein Ontology PR:000009758 leptin
References
(Earliest) J:13066 INGALLS AM, et al., Obese, a new mutation in the house mouse. J Hered. 1950 Dec;41(12):317-8
(Latest) J:222740 Miao J, et al., Flavin-containing monooxygenase 3 as a potential player in diabetes-associated atherosclerosis. Nat Commun. 2015;6:6498
All references(1180)
Disease annotation references (16)
Other
accession IDs
MGD-MRK-12967, MGD-MRK-26103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory