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Lep
Gene Detail
 Symbol
Name
ID
Lep
leptin
MGI:104663
Feature Type protein coding gene
Genetic Map
Chromosome 6
12.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr6:29060220-29073877 bp, + strand
From VEGA annotation of GRCm38

  13658 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:193  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 western clawed frog

Protein SuperFamily: leptin
Gene Tree: Lep

Human
homologs
Human Homolog LEP, leptin
NCBI Gene ID 3952
neXtProt AC  NX_P41159
Human Synonyms  LEPD, OB, OBS
Human Chr (Location)  7q31.3; chr7:128241189-128257629 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human LEP
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Chemically induced (ENU)(2) Spontaneous(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes are obese, hyperphagic, have low activity, high metabolic efficiency, impaired thermogenesis, infertility and short lifespan in addition to varying other abnormalities. Strain background affects severity and course of diabetes. Heterozygotes survive fasting longer than control mice.
 
Human Diseases Modeled Using Mouse Lep (2)    Alleles Annotated to Human Diseases(2)    Phenotype Images(2)
Interactions
Lep interacts with 264 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (71 annotations)
Process adipose tissue development, adult feeding behavior, ...
Component cell, cytoplasm, ...
Function growth factor activity, hormone activity, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (91)    Tissues (53)    Images (19)
Theiler Stages: 23, 28
Assay TypeResults
RNA in situ 28
Northern blot 17
RT-PCR 46
cDNA source data(31)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(51) Genomic(12) cDNA(34) Primer pair(5)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000035815 (Evidence)
Ensembl Gene ModelENSMUSG00000059201 (Evidence)
Entrez Gene16846 (Evidence)
UniGene277072
DFCITC1586285, TC1618163
DoTSDT.491758
NIA Mouse Gene IndexU006609
Consensus CDS ProjectCCDS19955.1
International Mouse Knockout Project StatusLep
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035815 VEGA Gene Model | MGI Sequence Detail 13658 C57BL/6J ±  kb
transcript OTTMUST00000091731 VEGA | MGI Sequence Detail 3259 Not Applicable 
polypeptide OTTMUSP00000050551 VEGA | MGI Sequence Detail 167 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(4) UniProt(4)
Polymorphisms All PCR and RFLP(5) : PCR(4) RFLP(1) SNPs within 2kb(140 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012351 Four-helical cytokine, core
InterPro IPR009079 Four-helical cytokine-like, core
InterPro IPR000065 Obesity factor
Protein Ontology PR:000009758 leptin
References (Earliest) J:13066 INGALLS AM, et al., Obese, a new mutation in the house mouse. J Hered. 1950 Dec;41(12):317-8
(Latest) J:212183 Gembardt F, et al., The SGLT2 inhibitor empagliflozin ameliorates early features of diabetic nephropathy in BTBR ob/ob type 2 diabetic mice with and without hypertension. Am J Physiol Renal Physiol. 2014 Aug 1;307(3):F317-25
All references(1117)
Disease annotation references (8)
Other
accession IDs
MGD-MRK-12967, MGD-MRK-26103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory