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Symbol
Name
ID
Lep
leptin
MGI:104663
Phenotype annotations related to skeleton
Darker colors indicate more annotations
Human Phenotypes
Accelerated skeletal maturation
Osteoporosis
Disease(s) Associated with LEP
congenital leptin deficiency
osteoporosis

Mouse Phenotypes
abnormal osteoclast differentiation
short humerus
short femur
short tibia
abnormal long bone epiphyseal plate morphology
abnormal long bone epiphyseal plate proliferative zone
abnormal long bone hypertrophic chondrocyte zone
decreased length of long bones
abnormal bone marrow morphology
decreased bone mass
increased bone mass
osteopetrosis
abnormal skeleton development
abnormal bone ossification
Availability Mouse Genotype
Lepob/Lepob
Leptm1b(EUCOMM)Hmgu/Leptm1b(EUCOMM)Hmgu
Leptm1Kry/Leptm1Kry
Lepob/Lep+
Tg(Apcs-Lep)1Yog/0
Tg(Apoe-Lep)1Kry/0

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory