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Symbol
Name
ID

Lep
leptin
MGI:104663

Phenotype annotations related to homeostasis/metabolism

*	Aspects of the system are reported to show a normal phenotype.
!	Indicates phenotype varies with strain background.
	Darker colors indicate more annotations

Human Phenotypes	Decreased T cell activation	Hypertriglyceridemia	Insulin-resistant diabetes mellitus	Type II diabetes mellitus	Hyperinsulinemia	Insulin resistance	Decreased serum leptin	Decreased serum testosterone concentration	Decreased serum estradiol
Disease(s) Associated with LEP	Decreased T cell activation	Hypertriglyceridemia	Insulin-resistant diabetes mellitus	Type II diabetes mellitus	Hyperinsulinemia	Insulin resistance	Decreased serum leptin	Decreased serum testosterone concentration	Decreased serum estradiol
congenital leptin deficiency
type 2 diabetes mellitus

Mouse Phenotypes

homeostasis/metabolism phenotype

abnormal response to cardiac infarction

abnormal vascular wound healing

abnormal insulin secretion

decreased insulin secretion

increased insulin secretion

increased susceptibility to diet-induced obesity

impaired adaptive thermogenesis

increased blood urea nitrogen level

abnormal circulating glucose level

increased fasting circulating glucose level

decreased circulating glucose level

hypoglycemia

increased circulating glucose level

hyperglycemia

abnormal circulating hormone level

decreased circulating testosterone level

increased circulating corticosterone level

decreased circulating follicle stimulating hormone level

decreased circulating luteinizing hormone level

decreased circulating prolactin level

decreased circulating insulin level

increased circulating insulin level

decreased circulating leptin level

increased circulating leptin level

abnormal circulating pancreatic peptide level

decreased circulating growth hormone level

abnormal circulating cholesterol level

increased circulating HDL cholesterol level

increased circulating LDL cholesterol level

increased circulating VLDL cholesterol level

increased circulating cholesterol level

decreased circulating free fatty acids level

increased circulating free fatty acids level

decreased circulating triglyceride level

increased circulating triglyceride level

decreased circulating tumor necrosis factor level

decreased body temperature

abnormal urine catecholamine level

abnormal oxygen consumption

decreased oxygen consumption

increased oxygen consumption

abnormal glucose homeostasis

impaired glucose tolerance

decreased liver glycogen level

increased urine glucose level

increased insulin sensitivity

insulin resistance

abnormal hormone level

abnormal corticosterone level

increased adrenocorticotropin level

decreased pituitary hormone level

increased pituitary hormone level

increased liver cholesterol level

increased cholesterol level

abnormal lipid level

decreased liver triglyceride level

increased liver triglyceride level

abnormal protein level

abnormal urine homeostasis

albuminuria

abnormal nucleotide metabolism

Availability

Mouse Genotype

Lep^m1Yst/Lep^m1Yst

Lep^ob/Lep^ob

*

!

Lep^tm1.2Gvcao/Lep^tm1.2Gvcao

Tg(Apcs-Lep)1Yog/0

Lep^tm1.1Gvcao/Lep^tm1.1Gvcao
Tg(Adipoq-cre)1Evdr/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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