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Symbol
Name
ID

Lep
leptin
MGI:104663

Phenotype annotations related to growth/size/body

Darker colors indicate more annotations

Human Phenotypes	Increased waist to hip ratio	Obesity
Disease(s) Associated with LEP	Increased waist to hip ratio	Obesity
congenital leptin deficiency
type 2 diabetes mellitus

Mouse Phenotypes

increased body fat mass

heart left ventricle hypertrophy

increased heart weight

increased pancreas weight

decreased lean body mass

increased lean body mass

decreased body weight

increased body weight

obese

decreased body length

increased body length

abnormal body weight

increased susceptibility to diet-induced obesity

abnormal postnatal growth

increased growth rate

enlarged kidney

increased kidney weight

increased liver weight

Availability

Mouse Genotype

Lep^m1Btlr/Lep^m1Btlr

Lep^m1Yst/Lep^m1Yst

Lep^m2Btlr/Lep^m2Btlr

Lep^ob/Lep^ob

Lep^ob/Lep^ob
Tg(Npy-MAPT/Sapphire)1Rck/0

Lep^ob/Lep^ob
Tg(Pomc-MAPT/Topaz)1Rck/0

Lep^tm1.2Gvcao/Lep^tm1.2Gvcao

Lep^tm1Kry/Lep^tm1Kry

Lep^ob/Lep⁺

Lep^ob/Lep^ob-2J

Tg(Apcs-Lep)1Yog/0

Lep^tm1.1Gvcao/Lep^tm1.1Gvcao
Tg(Adipoq-cre)1Evdr/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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