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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Smo
smoothened, frizzled class receptor
MGI:108075
177 phenotypes from 11 alleles in 30 genetic backgrounds
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Allelic Composition
Genetic Background		 Annotated Term Reference
Gli1tm3(cre/ERT2)Alj/Gli1+
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+
involves: 129S6/SvEvTac * 129X1/SvJ 		normal respiratory system phenotype J:264185
Gli1tm3(cre/ERT2)Alj/Gli1+
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
involves: 129S6/SvEvTac * 129X1/SvJ 		increased medulloblastoma incidence J:139574
premature death J:139574
Gli2tm1(cre/ERT2)Tipe/Gli2+
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+
involves: 129X1/SvJ 		abnormal bronchioalveolar stem cell morphology J:264185
abnormal pulmonary alveolus morphology J:264185
decreased type II pneumocyte number J:264185
emphysema J:264185
overexpanded pulmonary alveolus J:264185
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/?
involves: 129X1/SvJ 		normal neoplasm J:114992
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+
Tg(Nes-cre)1Kln/0
involves: 129X1/SvJ * C57BL/6 * SJL 		abnormal lateral geniculate nucleus morphology J:147427
abnormal thalamus morphology J:147427
increased brain size J:147427
neonatal lethality, complete penetrance J:147427
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129X1/SvJ * C57BL/6J * CBA/J 		abnormal cardiac outflow tract development J:135134
embryonic lethality during organogenesis, incomplete penetrance J:135134
increased cardiac neural crest cell number J:135134
persistent truncus arteriosus J:135134
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+
Ndor1Tg(UBC-cre/ERT2)1Ejb/0
involves: 129S/SvEv * 129X1/SvJ * C57BL/6 		abnormal pulmonary alveolus morphology J:264185
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+
Olig3tm1(cre)Ynka/Olig3+
involves: 129X1/SvJ * C57BL/6 * SJL 		abnormal lateral geniculate nucleus morphology J:147427
abnormal thalamus morphology J:147427
normal nervous system phenotype J:147427
prenatal lethality, incomplete penetrance J:147427
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+
Nkx3-2tm1(cre)Wez/Nkx3-2+
involves: 129S7/SvEvBrd * 129X1/SvJ 		abnormal intestine development J:199664
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sor+
Tg(Pdgfra-cre/ERT)467Dbe/0
involves: 129X1/SvJ * C57BL/6 * SJL 		abnormal pulmonary alveolus morphology J:264185
emphysema J:264185
overexpanded pulmonary alveolus J:264185
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Olig2tm2(TVA,cre)Rth/Olig2+
involves: 129 * 129X1/SvJ 		increased medulloblastoma incidence J:139574
premature death J:139574
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Shhtm2(cre/ERT2)Cjt/Shh+
involves: 129S6/SvEvTac * 129X1/SvJ 		normal neoplasm J:139574
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Tg(Atoh1-cre/Esr1*)14Fsh/0
involves: 129X1/SvJ * FVB/N 		abnormal cerebellum external granule cell layer morphology J:139574
increased medulloblastoma incidence J:139574
premature death J:139574
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Tg(GFAP-cre)25Mes/0
involves: 129X1/SvJ * FVB/N 		increased medulloblastoma incidence J:139574
premature death J:139574
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Tg(Krt1-5-cre/ERT)1Ipc/0
involves: 129X1/SvJ * C57BL/6 * SJL 		increased basal cell carcinoma incidence J:158915
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/Gt(ROSA)26Sortm1(Smo/EYFP)Amc
Tlx3tm1(cre)Qima/Tlx3+
involves: 129X1/SvJ 		increased medulloblastoma incidence J:139574
premature death J:139574
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/?
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129X1/SvJ * C57BL/6J * CBA/J 		abnormal face development J:89445
abnormal head development J:89445
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/?
Tg(CAG-cre/Esr1*)5Amc/?
involves: 129X1/SvJ * C57BL/6 * CBA 		abnormal pancreas morphology J:114992
gastric polyps J:114992
increased basal cell carcinoma incidence J:114992
increased medulloblastoma incidence J:114992
increased rhabdomyosarcoma incidence J:114992
intestine polyps J:114992
premature death J:114992
Gt(ROSA)26Sortm1(Smo/EYFP)Amc/?
Tg(Pbsn-cre)4Prb/?
involves: 129X1/SvJ * C57BL/6 * DBA/2 		normal endocrine/exocrine gland phenotype J:114992
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sortm7(SMO*/YFP)Amc
Tg(CAG-cre/Esr1*)5Amc/0
chimera involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA * Swiss Webster 		abnormal brain development J:165962
polydactyly J:165962
Gt(ROSA)26Sortm7(SMO*/YFP)Amc/Gt(ROSA)26Sor+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129S4/SvJae * 129X1/SvJ * C57BL/6 * CBA * Swiss Webster 		abnormal brain development J:165962
abnormal frontonasal prominence morphology J:165962
Olig3tm1(cre)Ynka/Olig3+
Smotm2Amc/Smotm2Amc
involves: 129X1/SvJ * C57BL/6J 		abnormal thalamus morphology J:147427
Smobnb/Smobnb
involves: C3H/HeJ * C57BL/6J 		abnormal direction of embryo turning J:48268
abnormal heart looping J:48268
broad limb buds J:48268
decreased embryo size J:48268
hemorrhage J:48268
incomplete embryo turning J:48268
pericardial edema J:48268
Smobnb/Smobnb
involves: C3HeB/FeJ * C57BL/6J 		abnormal left-right axis patterning J:98216
abnormal spinal cord morphology J:98216
embryonic lethality during organogenesis, complete penetrance J:98216
Smorgsc2073/Smorgsc2073
either: B6JJcl(C3JJcl)-Smorgsc2073 or B6JJcl(D2JJcl)-Smorgsc2073 		abnormal left-right axis patterning J:228335
embryonic growth retardation J:228335
embryonic lethality, complete penetrance J:228335
holoprosencephaly J:228335
Smotm1.1Pab/Smotm1.1Pab
Not Specified 		abnormal developmental patterning J:79457
abnormal embryo turning J:79457
abnormal first pharyngeal arch morphology J:79457
abnormal neural fold formation J:79457
abnormal neural plate morphology J:79457
abnormal optic vesicle formation J:79457
decreased embryo size J:79457
distended pericardium J:79457
fused first pharyngeal arch J:79457
Smotm1Amc/Smotm1Amc
involves: 129X1/SvJ * C57BL/6 		abnormal embryo development J:128367
abnormal embryo turning J:128367
abnormal vitelline vasculature morphology J:128367
Smotm1Amc/Smotm1Amc
involves: 129X1/SvJ * CD-1 		absent neuronal precursor cells J:152259
embryonic growth retardation J:152259
Smotm1Amc/Smotm1Amc
Tg(Pdx1-cre)6Tuv/0
involves: 129X1/SvJ * FVB/N 		normal digestive/alimentary phenotype J:151981
Smotm1Amc/Smotm2Amc
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: C57BL/6J * CBA/J 		abnormal basisphenoid bone morphology J:89445
abnormal craniofacial development J:89445
abnormal cranium morphology J:89445
abnormal ethmoid bone morphology J:89445
abnormal mandible morphology J:89445
abnormal mandibular condyloid process morphology J:89445
abnormal maxilla morphology J:89445
abnormal sphenoid bone morphology J:89445
abnormal temporal bone morphology J:89445
abnormal thyroid cartilage morphology J:89445
abnormal tooth morphology J:89445
absent gonial bone J:89445
absent incus J:89445
absent lacrimal bone J:89445
absent lower incisors J:89445
absent malleus J:89445
absent middle ear ossicles J:89445
absent orbitosphenoid bone J:89445
absent palatine bone J:89445
absent presphenoid bone J:89445
absent pterygoid process J:89445
absent Reichert cartilage J:89445
absent stapes J:89445
absent styloid process J:89445
absent tongue J:89445
absent tympanic ring J:89445
absent vomer bone J:89445
Meckel's cartilage hypoplasia J:89445
nasal bone hypoplasia J:89445
nasal septum hypoplasia J:89445
short Meckel's cartilage J:89445
small alisphenoid bone J:89445
small temporal bone squamous part J:89445
small zygomatic bone J:89445
Smotm1Amc/Smotm2Amc
Isl1tm1(cre)Sev/Isl1+
involves: 129S/Sv * 129X1/SvJ 		abnormal aortic arch morphology J:110602
abnormal cardiac neural crest cell migration J:110602
abnormal cardiac outflow tract development J:110602
abnormal sixth pharyngeal arch artery morphology J:110602
atrial septal defect J:110602
perinatal lethality J:110602
persistent truncus arteriosus J:110602
right aortic arch J:110602
transposition of great arteries J:110602
ventricular septal defect J:110602
Smotm1Amc/Smotm2Amc
Tg(Col2a1-cre)3Amc/0
involves: 129X1/SvJ 		decreased length of long bones J:73071
Smotm1Amc/Smotm2Amc
Tg(Col2a1-cre)10Amc/0
involves: 129X1/SvJ 		abnormal digit morphology J:73071
abnormal skeleton development J:73071
decreased chondrocyte proliferation J:73071
decreased length of long bones J:73071
postnatal lethality, complete penetrance J:73071
short fibula J:73071
short humerus J:73071
short limbs J:73071
short scapula J:73071
short tibia J:73071
short ulna J:73071
Smotm1Amc/Smotm2Amc
Tg(Col2a1-cre)15Amc/0
involves: 129X1/SvJ 		decreased length of long bones J:73071
Smotm1Amc/Smotm2Amc
Tg(Fgf15-cre)1Hisa/0
involves: 129X1/SvJ 		abnormal diencephalon morphology J:156737
abnormal lens development J:156737
abnormal optic cup morphology J:156737
abnormal optic stalk morphology J:156737
abnormal optic vesicle formation J:156737
abnormal otic vesicle development J:156737
anophthalmia J:156737
decreased embryo size J:156737
forebrain hypoplasia J:156737
Smotm1Amc/Smotm2Amc
Tg(KRT14-cre)1Amc/0
involves: 129X1/SvJ * C57BL/6 * CBA 		abnormal ameloblast morphology J:80081
abnormal enamel organ morphology J:80081
abnormal incisor morphology J:80081
abnormal inner dental epithelium morphology J:80081
abnormal molar cusp morphology J:80081
abnormal molar morphology J:80081
abnormal outer dental epithelium morphology J:80081
abnormal stellate reticulum morphology J:80081
absent enamel cord J:80081
absent Tomes' process J:80081
fused molars J:80081
neonatal lethality, complete penetrance J:80081
Smotm1Amc/Smotm2Amc
Tg(Nes-cre)1Kln/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL * Swiss Webster 		abnormal cerebellar foliation J:108507
abnormal cerebellum morphology J:108507
decreased brain size J:108507
postnatal lethality, incomplete penetrance J:108507
small cerebellum J:108507
Smotm1Amc/Smotm2Amc
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
involves: 129X1/SvJ * CD-1 		no abnormal phenotype detected J:114494
Smotm1b(KOMP)Wtsi/Smo+
C57BL/6N-Smotm1b(KOMP)Wtsi/Bay 		abnormal skin morphology J:211773
decreased heart rate J:211773
increased heart rate variability J:211773
prolonged RR interval J:211773
Smotm1b(KOMP)Wtsi/Smotm1b(KOMP)Wtsi
C57BL/6N-Smotm1b(KOMP)Wtsi/Bay 		abnormal embryo development J:211773
abnormal embryo turning J:211773
abnormal pericardium morphology J:211773
embryonic lethality prior to tooth bud stage J:211773
preweaning lethality, complete penetrance J:211773
Smotm2Amc/Smotm2.1Amc
H2az2Tg(Wnt1-cre)11Rth/H2az2+
involves: 129X1/SvJ * C57BL/6J * CBA/J 		abnormal artery morphology J:135134
abnormal cardiac outflow tract development J:135134
abnormal neural crest cell apoptosis J:135134
persistent truncus arteriosus J:135134
pulmonary artery hypoplasia J:135134
transposition of great arteries J:135134
Smotm2Amc/Smotm2.1Amc
Nkx2-5tm1(cre)Rjs/Nkx2-5+
involves: 129S7/SvEvBrd * 129X1/SvJ 		abnormal artery morphology J:135134
abnormal cardiac outflow tract development J:135134
abnormal neural crest cell apoptosis J:135134
abnormal neural crest cell migration J:135134
persistent truncus arteriosus J:135134
Smotm2Amc/Smotm2.1Amc
Tg(Mpz-cre)94Imeg/0
involves: 129X1/SvJ 		abnormal cardiovascular development J:135134
Smotm2Amc/Smotm2.1Amc
Tg(Tek-cre)12Flv/0
involves: 129X1/SvJ * C57BL/6 		normal cardiovascular system phenotype J:135134
Smotm2Amc/Smotm2.1Amc
Tg(Tnnt2-cre)5Blh/0
involves: 129X1/SvJ * C57BL/6 * DBA/2 		normal cardiovascular system phenotype J:135134
Smotm2Amc/Smotm2Amc
Isl1tm1(cre)Tmj/Isl1+
involves: 129S/Sv * 129X1/SvJ 		abnormal blood circulation J:204743
abnormal heart right ventricle morphology J:204743
blood vessel atresia J:204743
persistent truncus arteriosus J:204743
Smotm2Amc/Smotm2Amc
Nkx3-2tm1(cre)Wez/Nkx3-2+
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ 		abnormal enteric neuron morphology J:199664
abnormal enterocyte proliferation J:199664
abnormal intestinal enteroendocrine cell morphology J:199664
abnormal intestinal goblet cell morphology J:199664
abnormal intestinal smooth muscle morphology J:199664
abnormal intestine development J:199664
abnormal intestine physiology J:199664
neonatal lethality, complete penetrance J:199664
Smotm2Amc/Smotm2Amc
Slc6a3tm1(cre)Xz/Slc6a3+
involves: 129S1/Sv * 129X1/SvJ 		normal nervous system phenotype J:188348
Smotm2Amc/Smotm2Amc
Tg(Gfap-cre)73.12Mvs/0
involves: 129X1/SvJ * BALB/c * C57BL/6NHsd 		astrocytosis J:165495
normal nervous system phenotype J:165495
Smotm2Amc/Smotm2Amc
Tg(mI56i-cre,EGFP)1Kc/?
involves: 129X1/SvJ * FVB/N 		no abnormal phenotype detected J:102950
Smotm2Amc/Smotm2Amc
Tg(Nes-cre)1Kln/0
involves: 129X1/SvJ * C57BL/6 * SJL 		abnormal thalamus morphology J:147427
Smotm2Amc/Smotm2Amc
Tg(Tek-cre)12Flv/0
involves: 129X1/SvJ * C3H * C57BL/6 		normal cardiovascular system phenotype J:204743
Tg(Neurod2-Smo*A1)199Jols/0
C57BL/6-Tg(Neurod2-Smo*A1)199Jols 		abnormal subarachnoid space morphology J:133312
decreased tumor-free survival time J:93861
increased cerebellar granule cell number J:93861
increased medulloblastoma incidence J:93861
Tg(Neurod2-Smo*A1)199Jols/0
involves: C57BL/6 		decreased tumor-free survival time J:221990
increased medulloblastoma incidence J:221990
Tg(Neurod2-Smo*A1)199Jols/Tg(Neurod2-Smo*A1)199Jols
C57BL/6-Tg(Neurod2-Smo*A1)199Jols 		abnormal cerebellum external granule cell layer morphology J:133312
abnormal cerebellum morphology J:133312
abnormal cranium morphology J:133312
abnormal subarachnoid space morphology J:133312
ataxia J:133312
decreased tumor-free survival time J:133312
head tilt J:133312
hunched posture J:133312
increased medulloblastoma incidence J:133312, J:189258
normal nervous system phenotype J:189258
weight loss J:133312
Tg(Neurod2-Smo*A2)#Jols/0
C57BL/6-Tg(Neurod2-Smo*A2)#Jols 		abnormal cerebellar granule cell morphology J:189258
abnormal cerebellum development J:189258
abnormal cerebellum external granule cell layer morphology J:189258
abnormal cerebellum morphology J:189258
abnormal head shape J:189258
abnormal neuron proliferation J:189258
abnormal neuronal migration J:189258
abnormal radial glial cell morphology J:189258
absent cerebellar foliation J:189258
normal behavior/neurological phenotype J:189258
decreased locomotor activity J:189258
ectopic Purkinje cell J:189258
head tilt J:189258
hunched posture J:189258
hydrocephaly J:189258
increased medulloblastoma incidence J:189258
increased neuronal precursor cell number J:189258
lethargy J:189258
normal neoplasm J:93861
weight loss J:189258
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory