Nkx2-5^tm1(cre)Rjs
Targeted Allele Detail

Summary

• Symbol: Nkx2-5^tm1(cre)Rjs
• Name: NK2 homeobox 5; targeted mutation 1, Robert J Schwartz
• MGI ID: MGI:2654594
• Synonyms: Nkx2.5^cre, Nkx2-5^Cre, Nkx2-5/Cre, Nkx2.5-Cre
• Gene: Nkx2-5 Location: Chr17:27057638-27063962 bp, - strand Genetic Position: Chr17, 13.6 cM
• Alliance: Nkx2-5^tm1(cre)Rjs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:73654
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Nkx2-5^tm1(cre)Rjs expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Nkx2-5 (MGI:97350)

• Mutation details: A cre recombinase gene followed by a neomycin selection cassette was inserted in-frame into exon 2. Reporter expression assays indicated that an active fusion protein was expressed from this allele in the embryonic heart, tongue, thymus and spleen. (J:73654)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Nkx2-5 (mouse) Summary of all recombinase alleles driven by Nkx2-5. Comparative matrix view of recombinase activities Alliance mouse Nkx2-5 gene page

Disease models

Expression

In Mice Carrying this Mutation:

232 assay results 15 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nkx2-5 Mutation: 21 strains or lines available

References

• Original: J:73654 Moses KA, et al., Embryonic expression of an Nkx2-5/Cre gene using ROSA26 reporter mice. Genesis. 2001 Dec;31(4):176-80
• All: 154 reference(s)