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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Ptch1
patched 1
MGI:105373
68 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Brca2tm1Brn/Brca2tm1Brn
Ptch1tm1Mps/Ptch1+
Trp53tm1Tyj/Trp53+
Tg(Nes-cre)1Kln/0
involves: 129 * C57BL/6 * SJL 		increased medulloblastoma incidence J:144617
Brca2tm1Brn/Brca2tm1Brn
Ptch1tm1Mps/Ptch1+
Trp53tm1Tyj/Trp53tm1Tyj
Tg(Nes-cre)1Kln/0
involves: 129 * C57BL/6 * SJL 		increased medulloblastoma incidence J:144617
Cdkn1btm1Mlf/Cdkn1b+
Ptch1tm1Mps/Ptch1+
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 		abnormal cerebellar molecular layer J:205254
hydrocephaly J:205254
increased gastrointestinal tumor incidence J:205254
increased hemangiosarcoma incidence J:205254
increased lymphoma incidence J:205254
increased medulloblastoma incidence J:205254
increased rhabdomyosarcoma incidence J:205254
increased tumor incidence J:205254
premature death J:205254
Cdkn1btm1Mlf/Cdkn1btm1Mlf
Ptch1tm1Mps/Ptch1+
involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 		abnormal cerebellar molecular layer J:205254
hydrocephaly J:205254
increased gastrointestinal tumor incidence J:205254
increased hemangiosarcoma incidence J:205254
increased lymphoma incidence J:205254
increased medulloblastoma incidence J:205254
increased rhabdomyosarcoma incidence J:205254
increased tumor incidence J:205254
premature death J:205254
Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Ptch1tm1Mps/Ptch1+
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ 		abnormal neuron differentiation J:102702
increased medulloblastoma incidence J:102702
Cdkn2ctm1Bbd/Cdkn2ctm1Bbd
Ptch1tm1Mps/Ptch1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal cerebellar molecular layer J:205254
increased medulloblastoma incidence J:205254
Chmp1aGt(XC472)Byg/Chmp1aGt(XC472)Byg
Ptch1tm1Mps/Ptch1+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 		normal nervous system phenotype J:271138
Ctnnb1tm1Yy/Ctnnb1tm1.1Yy
Ptch1tm1Yy/Ptch1tm1.1Yy
Tg(Col2a1-cre)1Bhr/0
involves: 129S6/SvEvTac * C57BL/6 * SJL 		abnormal elbow joint morphology J:112462
abnormal long bone hypertrophic chondrocyte zone J:112462
abnormal perichondrium morphology J:112462
arrested osteoblast differentiation J:112462
normal craniofacial phenotype J:112462
decreased bone mineralization J:112462
delayed endochondral bone ossification J:112462
fused synovial joints J:112462
Disp1icb/Disp1icb
Ptch1tm1Mps/Ptch1tm1Mps
involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J 		abnormal head morphology J:79027
abnormal neural tube morphology J:79027
embryonic lethality, complete penetrance J:79027
open neural tube J:79027
Disp1tm1Amc/Disp1tm1Amc
Ptch1tm1Mps/Ptch1+
involves: 129S1/Sv * 129X1/SvJ 		normal nervous system phenotype J:92058
no abnormal phenotype detected J:92058
Dync2h1lln/Dync2h1lln
Ptch1tm1Mps/Ptch1tm1Mps
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		embryonic lethality during organogenesis, complete penetrance J:100466
Gli1tm1Alj/Gli1tm1Alj
Ptch1tm1Mps/Ptch1tm1Mps
involves: 129S1/Sv * 129X1/SvJ * Black Swiss * Swiss Webster 		embryonic lethality during organogenesis, complete penetrance J:79392
Gli2tm1Alj/Gli2tm1Alj
Ptch1tm1Mps/Ptch1tm1Mps
involves: 129S1/Sv * 129X1/SvJ * Swiss Webster 		abnormal brain development J:79392
abnormal spinal cord morphology J:79392
abnormal ventral interneuron 3 morphology J:79392
embryonic lethality during organogenesis, complete penetrance J:79392
exencephaly J:79392
increased motor neuron number J:79392
normal nervous system phenotype J:79392
Gli2tm3.1Blnw/Gli2tm3.1Blnw
Ptch1tm1Mps/?
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C3H * C57BL/6 		abnormal neural tube morphology J:186503
Gpr37l1tm1.2Gtva/Gpr37l1tm1.2Gtva
Ptch1tm1Zim/Ptch1+
STOCK Gpr37l1tm1.2Gtva Ptch1tm1Zim/Cnrm 		decreased cerebellar granule cell precursor proliferation J:272049
hydrocephaly J:272049
increased medulloblastoma incidence J:272049
increased tumor incidence J:272049
increased tumor latency J:272049
HhatTg(TFAP2A-cre)1Will/Hhat+
Ptch1tm1Mps/Ptch1+
involves: 129S1/Sv * 129X1/SvJ 		abnormal craniofacial morphology J:190013
Hhiptm1Amc/Hhip+
Ptch1tm1Mps/Ptch1tm1Mps
Tg(Mt1-Ptch1)MT22Mps/0
involves: 129S1/Sv * 129X1/SvJ * FVB 		abnormal neural tube morphology J:94269
abnormal neuronal precursor cell number J:94269
exencephaly J:94269
small first pharyngeal arch J:94269
spina bifida J:94269
Hhiptm1Amc/Hhiptm1Amc
Ptch1tm1Mps/Ptch1+
involves: 129S1/Sv * 129X1/SvJ 		abnormal branching involved in pancreas development J:85472
abnormal neural tube morphology J:94269
abnormal pancreas development J:85472
abnormal pulmonary alveolar duct morphology J:94269
abnormal stomach glandular epithelium morphology J:85472
embryonic lethality, complete penetrance J:85472
incomplete rostral neuropore closure J:94269
increased embryo size J:94269
increased neuronal precursor cell number J:94269
small lung J:85472
Hhiptm1Amc/Hhiptm1Amc
Ptch1tm1Mps/Ptch1tm1Mps
Tg(Mt1-Ptch1)MT22Mps/0
involves: 129S1/Sv * 129X1/SvJ * FVB 		abnormal neural tube morphology J:94269
abnormal neuronal precursor cell number J:94269
anophthalmia J:94269
embryonic lethality during organogenesis, incomplete penetrance J:94269
enlarged first pharyngeal arch J:94269
enlarged floor plate J:94269
incomplete rostral neuropore closure J:94269
Ihhtm1Amc/Ihhtm1Amc
Ptch1tm1Mps/Ptch1+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal palatal shelf bone ossification J:182649
Kif7maki/Kif7maki
Ptch1tm1Mps/Ptch1tm1Mps
Tg(Hlxb9-GFP)1Tmj/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/N 		abnormal neural tube morphology J:151965
embryonic lethality during organogenesis, complete penetrance J:151965
Mtss1tm1Pla/Mtss1tm1Pla
Ptch1tm1Mps/Ptch1tm1Mps
involves: 129S1/Sv * 129X1/SvJ 		embryonic lethality, complete penetrance J:182970
Parms1BALB/cByJ/Parms1C57BL/6NCrl
Ptch1tm1Zim/Ptch1+
involves: 129/Sv * BALB/cByJ * C57BL/6NCrl 		increased rhabdomyosarcoma incidence J:93364
Parms1C57BL/6NCrl/Parms1C57BL/6NCrl
Ptch1tm1Zim/Ptch1+
involves: 129/Sv * BALB/cByJ * C57BL/6NCrl 		increased rhabdomyosarcoma incidence J:93364
Pgbd5tm1.1Aken/Pgbd5tm1.2Aken
Ptch1tm1Bjw/Ptch1tm1Bjw
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129 * C57BL/6J * C57BL/6NTac * FVB/N * SW 		increased medulloblastoma incidence J:346387
Pgbd5tm1.2Aken/Pgbd5tm1.2Aken
Ptch1tm1Bjw/Ptch1tm1Bjw
Ptf1atm1.1(cre)Cvw/Ptf1a+
involves: 129 * C57BL/6J * C57BL/6NTac * FVB/N * SW 		decreased classified tumor incidence J:346387
increased tumor-free survival time J:346387
Ptch1tm1Cklr/Ptch1+
Trp53tm1Brn/?
Pax7tm1(cre)Mrc/Pax7+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL 		increased medulloblastoma incidence J:159972
Ptch1tm1Mps/Ptch1+
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129 * 129S2/SvPas * C57BL/6 		increased medulloblastoma incidence J:125534
increased rhabdomyosarcoma incidence J:125534
premature death J:125534
Ptch1tm1Mps/Ptch1+
Ptch2tm1Pmc/Ptch2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal intestine morphology J:112118
decreased tumor latency J:112118
increased basal cell carcinoma incidence J:112118
increased rhabdomyosarcoma incidence J:112118
increased testicular teratoma incidence J:112118
telangiectasia J:112118
Ptch1tm1Mps/Ptch1+
Ptch2tm1Pmc/Ptch2+
Trp53tm1Tyj/Trp53tm1Tyj
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 		normal neoplasm J:112118
Ptch1tm1Mps/Ptch1+
Ptch2tm1Pmc/Ptch2tm1Pmc
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 		abnormal intestine morphology J:112118
decreased tumor latency J:112118
increased basal cell carcinoma incidence J:112118
increased medulloblastoma incidence J:112118
increased rhabdomyosarcoma incidence J:112118
increased tumor incidence J:112118
Ptch1tm1Mps/Ptch1+
Tg(Shh)#Dje/0
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * Swiss Webster 		abnormal cerebellar foliation J:108507
abnormal cerebellum development J:108507
abnormal cerebellum morphology J:108507
Ptch1tm1Mps/Ptch1+
Shhtm6Amc/Shhtm6Amc
involves: 129S1/Sv * 129X1/SvJ 		no abnormal phenotype detected J:132152
Ptch1tm1Mps/Ptch1+
Tg(Atoh1-sb11)1Mtay/0
TgTn(sb-T2/Onc3)12740Njen/0
involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6J * ICR 		increased medulloblastoma incidence J:181542
Ptch1tm1Mps/Ptch1tm1Mps
Tmem107schlei/Tmem107schlei
involves: 129S1/Sv * 129X1/SvJ * C3HeB/FeJ * C57BL/6J 		abnormal head morphology J:186552
abnormal neural tube closure J:186552
decreased embryo size J:186552
exencephaly J:186552
Ptch1tm1Mps/Ptch1tm1Mps
Wdpcpcys40/Wdpcpcys40
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J 		abnormal embryo development J:205269
Ptch1tm1Yy/Ptch1+
Trp53tm1Brd/Trp53+
Tg(BGLAP-cre)1Clem/0
involves: 129S7/SvEvBrd * C57BL/6 * FVB/NJ 		increased metastatic potential J:214349
increased osteosarcoma incidence J:214349
paralysis J:214349
Ptch1tm1Zim/Ptch1tm1Zim
Stiltm1Mku/Stiltm1Mku
involves: 129 		abnormal apoptosis J:72500
embryonic lethality during organogenesis, complete penetrance J:72500
holoprosencephaly J:72500
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory