TgTn(sb-T2/Onc3)12740Njen
Transgene Detail

Summary

• Symbol: TgTn(sb-T2/Onc3)12740Njen
• Name: transgenic transposon concatemer 12740, Nancy A Jenkins
• MGI ID: MGI:4367093
• Synonyms: T2/Onc3, T2Onc3(12740), TG12740
• Transgene: TgTn(sb-T2/Onc3)12740Njen Location: unknown Genetic Position: Chr9, Syntenic
• Alliance: TgTn(sb-T2/Onc3)12740Njen page

Transgene origin

• Strain of Origin: (C57BL/6J x C3H)F1

Transgene description

• Transgene Type: Transgenic (Transposon concatemer)
• Mutation: Insertion
• Mutation details: A concatemer of sleeping beauty transposable elements each consisting of optimized inverted repeat direct repeat sequence specific for sleeping beauty transposase flanking splice acceptor sites (from engrailed-2) and poly A signals in both orientations. Between the splice acceptor sites is the sequence for the CAG promoter followed by a splice donor site. Two lines were created (lines 12740 and 12775) with 11 and 28 copies of the transgenic transposon concatemer inserted into chromosome 9 and 12, respectively. Line 12740 was selected as the representative line. (J:153656)

Tumor Data

List all tumor models in MMHCdb carrying TgTn(sb-T2/Onc3)12740Njen

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:153656 Dupuy AJ, et al., A modified sleeping beauty transposon system that can be used to model a wide variety of human cancers in mice. Cancer Res. 2009 Oct 15;69(20):8150-6
• All: 19 reference(s)