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Srfbp1 Gene Detail
Summary
  • Symbol
    Srfbp1
  • Name
    serum response factor binding protein 1
  • Synonyms
    2810036K01Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1914472
    NCBI Gene: 67222
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:52598765-52625003 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 18, 28.21 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1148 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1914472
protein coding gene Chr18:52598703-52625005 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024427
protein coding gene Chr18:51584717-51611765 (+)
A/J MGP_AJ_G0024393
protein coding gene Chr18:49593026-49623187 (+)
AKR/J MGP_AKRJ_G0024363
protein coding gene Chr18:50984243-51013269 (+)
BALB/cJ MGP_BALBcJ_G0024393
protein coding gene Chr18:49765170-49790911 (+)
C3H/HeJ MGP_C3HHeJ_G0024160
protein coding gene Chr18:51119271-51144464 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024839
protein coding gene Chr18:53313921-53340133 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022271
protein coding gene Chr18:49400901-49426417 (+)
CAST/EiJ MGP_CASTEiJ_G0023634
protein coding gene Chr18:51074055-51101471 (+)
CBA/J MGP_CBAJ_G0024130
protein coding gene Chr18:54872605-54915158 (+)
DBA/2J MGP_DBA2J_G0024260
protein coding gene Chr18:49303724-49328934 (+)
FVB/NJ MGP_FVBNJ_G0024227
protein coding gene Chr18:48738437-48763902 (+)
LP/J MGP_LPJ_G0024345
protein coding gene Chr18:51612242-51639798 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024257
protein coding gene Chr18:56653306-56680670 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024886
protein coding gene Chr18:50989433-51022732 (+)
PWK/PhJ MGP_PWKPhJ_G0023378
protein coding gene Chr18:49328362-49353352 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023184
protein coding gene Chr18:51174021-51203585 (+)
WSB/EiJ MGP_WSBEiJ_G0023697
protein coding gene Chr18:50901017-50932571 (+)



Homology
more
  • Human Ortholog
    SRFBP1, serum response factor binding protein 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SRFBP1, serum response factor binding protein 1
  • Synonyms
    BUD22, P49, p49/STRAP, Rlb1, STRAP
  • Links
    NCBI Gene ID: 153443
    neXtProt AC: NX_Q8NEF9
    UniProt: Q8NEF9

  • Chr Location
    5q23.1; chr5:121961975-122078935 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024528 Ensembl Gene Model | MGI Sequence Detail 26239 C57BL/6J ±  kb
transcript ENSMUST00000025406 Ensembl | MGI Sequence Detail 2656 Not Applicable  
polypeptide ENSMUSP00000025406 Ensembl | MGI Sequence Detail 441 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 46
    cDNA 44
    Primer pair 1
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 35
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:327181 Lewis MA, et al., Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme. BMC Biol. 2022 Mar 17;20(1):67

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
07/05/2024
MGI 6.24
The Jackson Laboratory