Comparative GO Graph (mouse, human, rat, zebrafish)

• Source: Alliance of Genome Resources

Graphs for Molecular Function, Cellular Component, Biological Process generated Fri Mar 10 16:36:22 2023.

Complete table of the annotations represented in this image is provided below.

Graphs display curated GO classifications for mouse, human, rat and zebrafish orthologs annotated from the biomedical literature.

• This class contains
  • Human genes NOD2
  • Mouse genes Nod2
  • Rat genes Nod2
  • Zfish genes nod2
• Annotations are indicated with nodes colored by organism: Human, Mouse, Rat, Zfish
• Relations between GO terms are indicated by colored edges "is_a"; "part_of"; "regulates"; "positively_regulates"; "negatively_regulates"
• GO annotations: Human from GOA; Mouse from MGI; Rat from RGD; Zebrafish from ZFIN.
• Only experimental annotations are displayed: EXP, IDA, IEP, IGI, IMP, IPI, HTP, HDA, HMP, HGI, HEP. Evidence codes are listed at the bottom of the page.

Molecular Function

Cellular Component

Biological Process

Full set of experimental annotations for Human-Rat-Zebrafish genes considered orthologs of Mouse in the Alliance stringent orthology set Nod2

Category	ID	Classification term	Gene	Evidence	Inferred from	Organism	Reference
Molecular Function	GO:0003779	actin binding	NOD2	IDA		Human	PMID:24790089
Molecular Function	GO:0050700	CARD domain binding	NOD2	IPI	UniProtKB:O43353	Human	PMID:11087742
Molecular Function	GO:0019899	enzyme binding	NOD2	IPI	UniProtKB:Q9P0J0	Human	PMID:15753091
Molecular Function	GO:0030544	Hsp70 protein binding	NOD2	IPI	UniProtKB:P0DMV8	Human	PMID:24790089
Molecular Function	GO:0030544	Hsp70 protein binding	NOD2	IPI	UniProtKB:P0DMV9	Human	PMID:24790089
Molecular Function	GO:0051879	Hsp90 protein binding	NOD2	IDA		Human	PMID:24790089
Molecular Function	GO:0032500	muramyl dipeptide binding	NOD2	IDA		Human	PMID:15998797
Molecular Function	GO:0032500	muramyl dipeptide binding	Nod2	IDA		Mouse	PMID:18167348
Molecular Function	GO:0032500	muramyl dipeptide binding	Nod2	IDA		Rat	PMID:16973131|RGD:1643119
Molecular Function	GO:0038187	pattern recognition receptor activity	NOD2	IDA		Human	PMID:31649195
Molecular Function	GO:0042834	peptidoglycan binding	NOD2	IDA		Human	PMID:15998797
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:Q9NPP4	Human	PMID:11472070
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:P29466	Human	PMID:15107016
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:Q9NPP4	Human	PMID:15107016
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:Q9P0J0	Human	PMID:15753091
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:Q96RT1	Human	PMID:16203728
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:Q96RT1-2	Human	PMID:16203728
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:Q96RT1	Human	PMID:16714539
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:Q7L5N1	Human	PMID:17337451
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:P29466	Human	PMID:18511561
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:O43353	Human	PMID:19337385
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:P59046	Human	PMID:19337385
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:Q96P20	Human	PMID:19337385
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:Q9C000	Human	PMID:19337385
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:Q6UX06	Human	PMID:20534456
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:P08670	Human	PMID:21699783
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:Q04724	Human	PMID:21699783
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:Q10471	Human	PMID:21699783
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:Q16537	Human	PMID:21699783
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:Q92993	Human	PMID:21699783
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:Q9Y3D6	Human	PMID:21699783
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:O43353	Human	PMID:21931826
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:P08670	Human	PMID:22684479
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:O60336	Human	PMID:22700971
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:O43353	Human	PMID:22829933
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:P14373	Human	PMID:22829933
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:Q676U5	Human	PMID:23376921
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:O75179	Human	PMID:23711367
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:Q8IY34	Human	PMID:24695226
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:Q8N697	Human	PMID:24695226
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:O43353	Human	PMID:27812135
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:O95751	Human	PMID:27812135
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:P08670	Human	PMID:27812135
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:P19012	Human	PMID:27812135
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:Q8IWZ3	Human	PMID:27812135
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:Q8IYJ2	Human	PMID:27812135
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:Q8WV44	Human	PMID:27812135
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:Q96C92	Human	PMID:27812135
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:Q96N67	Human	PMID:27812135
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:Q9BZL4	Human	PMID:27812135
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:Q9NZZ3	Human	PMID:27812135
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:Q9Y5P8	Human	PMID:27812135
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:Q3KP66	Human	PMID:28436939
Molecular Function	GO:0005515	protein binding	NOD2	IPI	UniProtKB:Q96RT1	Human	PMID:30833792
Molecular Function	GO:0005515	protein binding	Nod2	IPI	UniProtKB:Q2LKU9	Mouse	MGI:MGI:4943384|PMID:18511561
Molecular Function	GO:0005515	protein binding	Nod2	IPI	PR:Q3UZZ4	Mouse	PMID:20534456
Molecular Function	GO:0005515	protein binding	Nod2	IPI	MGI:MGI:2685628	Mouse	PMID:17187069
Molecular Function	GO:0005515	protein binding	nod2	IPI	ZFIN:ZDB-GENE-081104-438	Zfish	PMID:27235368
Molecular Function	GO:0005515	protein binding	nod2	IPI	ZFIN:ZDB-GENE-090821-7	Zfish	PMID:27235368
Molecular Function	GO:0019901	protein kinase binding	NOD2	IPI	UniProtKB:O43318	Human	PMID:15075345
Molecular Function	GO:0019901	protein kinase binding	NOD2	IPI	UniProtKB:O43353	Human	PMID:24790089
Molecular Function	GO:0019901	protein kinase binding	NOD2	IPI	UniProtKB:O75385	Human	PMID:25891078
Molecular Function	GO:0030296	protein tyrosine kinase activator activity	NOD2	IDA		Human	PMID:31649195
Molecular Function	GO:0044877	protein-containing complex binding	NOD2	IPI	ComplexPortal:CPX-1870	Human	PMID:17337451
Molecular Function	GO:0030546	signaling receptor activator activity	NOD2	IDA		Human	PMID:15998797
Cellular Component	GO:0016323	basolateral plasma membrane	NOD2	IDA		Human	PMID:16203728
Cellular Component	GO:0009986	cell surface	NOD2	IDA		Human	PMID:16714539
Cellular Component	GO:0005737	cytoplasm	NOD2	IDA		Human	PMID:21887730
Cellular Component	GO:0005737	cytoplasm	NOD2	IDA		Human	PMID:24790089
Cellular Component	GO:0005737	cytoplasm	NOD2	IDA		Human	PMID:25093298
Cellular Component	GO:0005737	cytoplasm	Nod2	IDA		Rat	PMID:19608614|RGD:2316255
Cellular Component	GO:0005737	cytoplasm	nod2	IDA		Zfish	PMID:27235368
Cellular Component	GO:0005856	cytoskeleton	NOD2	IDA		Human	PMID:21887730
Cellular Component	GO:0005829	cytosol	NOD2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0005829	cytosol	NOD2	IDA		Human	PMID:15998797
Cellular Component	GO:0005829	cytosol	NOD2	IDA		Human	PMID:31649195
Cellular Component	GO:0005794	Golgi apparatus	NOD2	IDA		Human	GO_REF:0000052
Cellular Component	GO:0045335	phagocytic vesicle	NOD2	IDA		Human	PMID:31649195
Cellular Component	GO:0005886	plasma membrane	NOD2	IDA		Human	PMID:15998797
Cellular Component	GO:0005886	plasma membrane	NOD2	IDA		Human	PMID:25093298
Cellular Component	GO:0005886	plasma membrane	NOD2	IMP		Human	PMID:31649195
Cellular Component	GO:0032991	protein-containing complex	NOD2	IDA		Human	PMID:21887730
Cellular Component	GO:0031982	vesicle	NOD2	IDA		Human	PMID:15998797
Cellular Component	GO:0031982	vesicle	NOD2	IDA		Human	PMID:21887730
Biological Process	GO:0002253	activation of immune response	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:15692051
Biological Process	GO:0002815	biosynthetic process of antibacterial peptides active against Gram-positive bacteria	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:15692051
Biological Process	GO:0071222	cellular response to lipopolysaccharide	NOD2	IMP		Human	PMID:27812135
Biological Process	GO:0071225	cellular response to muramyl dipeptide	NOD2	IDA		Human	PMID:21887730
Biological Process	GO:0071225	cellular response to muramyl dipeptide	NOD2	IMP		Human	PMID:25093298
Biological Process	GO:0071225	cellular response to muramyl dipeptide	NOD2	IMP		Human	PMID:27812135
Biological Process	GO:0071407	cellular response to organic cyclic compound	Nod2	IEP		Rat	PMID:20863826|RGD:5508733
Biological Process	GO:0071224	cellular response to peptidoglycan	Nod2	IMP	MGI:MGI:2680581	Mouse	PMID:16949315
Biological Process	GO:0071224	cellular response to peptidoglycan	Nod2	IEP		Rat	PMID:24169446|RGD:13204728
Biological Process	GO:0042742	defense response to bacterium	NOD2	IDA		Human	PMID:15653568
Biological Process	GO:0042742	defense response to bacterium	nod2	IMP	ZFIN:ZDB-MRPHLNO-111222-4	Zfish	PMID:21729873
Biological Process	GO:0050830	defense response to Gram-positive bacterium	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:15692051
Biological Process	GO:0050830	defense response to Gram-positive bacterium	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:18261938
Biological Process	GO:0050830	defense response to Gram-positive bacterium	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:19139201
Biological Process	GO:0050830	defense response to Gram-positive bacterium	Nod2	IGI	MGI:MGI:1341839	Mouse	PMID:18261938
Biological Process	GO:0051607	defense response to virus	nod2	IDA		Zfish	PMID:27235368
Biological Process	GO:0016045	detection of bacterium	NOD2	IDA		Human	PMID:15653568
Biological Process	GO:0032498	detection of muramyl dipeptide	NOD2	IDA		Human	PMID:12527755
Biological Process	GO:0032498	detection of muramyl dipeptide	NOD2	IDA		Human	PMID:15998797
Biological Process	GO:0070371	ERK1 and ERK2 cascade	Nod2	IDA		Mouse	PMID:18261938
Biological Process	GO:0051649	establishment of localization in cell	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:19139201
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	Nod2	IDA		Mouse	PMID:18261938
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	nod2	IDA		Zfish	PMID:28555019
Biological Process	GO:0007249	I-kappaB kinase/NF-kappaB signaling	nod2	IMP	ZFIN:ZDB-MRPHLNO-180129-2	Zfish	PMID:28555019
Biological Process	GO:0002381	immunoglobulin production involved in immunoglobulin-mediated immune response	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:15692051
Biological Process	GO:0045087	innate immune response	NOD2	IDA		Human	PMID:23806334
Biological Process	GO:0002227	innate immune response in mucosa	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:15692051
Biological Process	GO:0032615	interleukin-12 production	Nod2	IMP	MGI:MGI:2680581	Mouse	PMID:14560001
Biological Process	GO:0032615	interleukin-12 production	Nod2	IMP	MGI:MGI:2680581	Mouse	PMID:15220916
Biological Process	GO:0032615	interleukin-12 production	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:15692051
Biological Process	GO:0032615	interleukin-12 production	Nod2	IDA		Mouse	PMID:15220916
Biological Process	GO:0032621	interleukin-18 production	Nod2	IMP	MGI:MGI:2680581	Mouse	PMID:15220916
Biological Process	GO:0032623	interleukin-2 production	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:19139201
Biological Process	GO:0032635	interleukin-6 production	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:15692051
Biological Process	GO:0032635	interleukin-6 production	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:18261938
Biological Process	GO:0032635	interleukin-6 production	Nod2	IDA		Mouse	PMID:18261938
Biological Process	GO:0032635	interleukin-6 production	Nod2	IGI	MGI:MGI:1341839	Mouse	PMID:18261938
Biological Process	GO:0035556	intracellular signal transduction	NOD2	IDA		Human	PMID:15653568
Biological Process	GO:0007254	JNK cascade	Nod2	IDA		Mouse	PMID:18261938
Biological Process	GO:0010934	macrophage cytokine production	Nod2	IGI	MGI:MGI:1341839	Mouse	PMID:18261938
Biological Process	GO:0010934	macrophage cytokine production	Nod2	IMP	MGI:MGI:2680581	Mouse	PMID:15220916
Biological Process	GO:0010934	macrophage cytokine production	Nod2	IDA		Mouse	PMID:15220916
Biological Process	GO:0010934	macrophage cytokine production	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:15692051
Biological Process	GO:0010934	macrophage cytokine production	Nod2	IMP	MGI:MGI:2680581	Mouse	PMID:14560001
Biological Process	GO:0010934	macrophage cytokine production	Nod2	IDA		Mouse	PMID:18261938
Biological Process	GO:0010934	macrophage cytokine production	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:18261938
Biological Process	GO:0071608	macrophage inflammatory protein-1 alpha production	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:19139201
Biological Process	GO:0030277	maintenance of gastrointestinal epithelium	NOD2	IMP		Human	PMID:17058067
Biological Process	GO:0000165	MAPK cascade	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:15692051
Biological Process	GO:0002862	negative regulation of inflammatory response to antigenic stimulus	Nod2	IMP	MGI:MGI:2680581	Mouse	PMID:16949315
Biological Process	GO:0032695	negative regulation of interleukin-12 production	Nod2	IDA		Mouse	PMID:15220916
Biological Process	GO:0032695	negative regulation of interleukin-12 production	Nod2	IMP	MGI:MGI:2680581	Mouse	PMID:16949315
Biological Process	GO:0032695	negative regulation of interleukin-12 production	Nod2	IMP	MGI:MGI:2680581	Mouse	PMID:15220916
Biological Process	GO:0032701	negative regulation of interleukin-18 production	Nod2	IMP	MGI:MGI:2680581	Mouse	PMID:15220916
Biological Process	GO:0032703	negative regulation of interleukin-2 production	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:19139201
Biological Process	GO:2000110	negative regulation of macrophage apoptotic process	Nod2	IDA		Mouse	MGI:MGI:4946442|PMID:21156799
Biological Process	GO:0010936	negative regulation of macrophage cytokine production	Nod2	IMP	MGI:MGI:2680581	Mouse	PMID:15220916
Biological Process	GO:0010936	negative regulation of macrophage cytokine production	Nod2	IDA		Mouse	PMID:15220916
Biological Process	GO:0032088	negative regulation of NF-kappaB transcription factor activity	Nod2	IMP	MGI:MGI:2680581	Mouse	PMID:15220916
Biological Process	GO:0002710	negative regulation of T cell mediated immunity	Nod2	IMP	MGI:MGI:2680581	Mouse	PMID:16949315
Biological Process	GO:0034136	negative regulation of toll-like receptor 2 signaling pathway	Nod2	IMP	MGI:MGI:2680581	Mouse	PMID:15220916
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:19139201
Biological Process	GO:0032689	negative regulation of type II interferon production	Nod2	IMP	MGI:MGI:2680581	Mouse	PMID:15220916
Biological Process	GO:0032689	negative regulation of type II interferon production	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:19139201
Biological Process	GO:0038061	NIK/NF-kappaB signaling	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:22033934
Biological Process	GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	NOD2	IDA		Human	PMID:12527755
Biological Process	GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	NOD2	IDA		Human	PMID:23806334
Biological Process	GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	NOD2	IDA		Human	PMID:31649195
Biological Process	GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	Nod2	IMP		Mouse	PMID:23892723
Biological Process	GO:0002221	pattern recognition receptor signaling pathway	NOD2	IDA		Human	PMID:31649195
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:15692051
Biological Process	GO:0006909	phagocytosis	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:19139201
Biological Process	GO:0006963	positive regulation of antibacterial peptide biosynthetic process	Nod2	IDA		Mouse	PMID:18167348
Biological Process	GO:0050871	positive regulation of B cell activation	NOD2	IDA		Human	PMID:20844241
Biological Process	GO:0006965	positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:15692051
Biological Process	GO:0008284	positive regulation of cell population proliferation	Nod2	IDA		Rat	PMID:16254493|RGD:1600785
Biological Process	GO:0002720	positive regulation of cytokine production involved in immune response	NOD2	IMP		Human	PMID:16260731
Biological Process	GO:1900017	positive regulation of cytokine production involved in inflammatory response	NOD2	IDA		Human	PMID:24671169
Biological Process	GO:0002606	positive regulation of dendritic cell antigen processing and presentation	Nod2	IMP		Mouse	MGI:MGI:4442557|PMID:20008287
Biological Process	GO:0002732	positive regulation of dendritic cell cytokine production	Nod2	IDA		Rat	PMID:16818757|RGD:1600784
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	Nod2	IMP		Mouse	MGI:MGI:4943376|PMID:18855982
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Nod2	IDA		Mouse	MGI:MGI:4946442|PMID:21156799
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:22033934
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	Nod2	IDA		Mouse	PMID:18261938
Biological Process	GO:0002925	positive regulation of humoral immune response mediated by circulating immunoglobulin	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:15692051
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	NOD2	IDA		Human	PMID:12527755
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	NOD2	IDA		Human	PMID:11087742
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	Nod2	IDA		Mouse	PMID:18261938
Biological Process	GO:0045089	positive regulation of innate immune response	Nod2	IDA		Mouse	MGI:MGI:4946442|PMID:21156799
Biological Process	GO:0045089	positive regulation of innate immune response	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:15692051
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	NOD2	IDA		Human	PMID:15107016
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	NOD2	IMP		Human	PMID:21040358
Biological Process	GO:0032731	positive regulation of interleukin-1 beta production	Nod2	IDA		Mouse	MGI:MGI:4943384|PMID:18511561
Biological Process	GO:0032733	positive regulation of interleukin-10 production	Nod2	IMP		Mouse	MGI:MGI:4946442|PMID:21156799
Biological Process	GO:0032735	positive regulation of interleukin-12 production	Nod2	IDA		Mouse	PMID:15220916
Biological Process	GO:0032735	positive regulation of interleukin-12 production	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:15692051
Biological Process	GO:0032735	positive regulation of interleukin-12 production	Nod2	IMP	MGI:MGI:2680581	Mouse	PMID:15220916
Biological Process	GO:0032735	positive regulation of interleukin-12 production	Nod2	IMP	MGI:MGI:2680581	Mouse	PMID:14560001
Biological Process	GO:0032740	positive regulation of interleukin-17 production	NOD2	IMP		Human	PMID:17919942
Biological Process	GO:0032755	positive regulation of interleukin-6 production	NOD2	IDA		Human	PMID:16414084
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:18261938
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Nod2	IDA		Mouse	PMID:18261938
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:15692051
Biological Process	GO:0032755	positive regulation of interleukin-6 production	Nod2	IGI	MGI:MGI:1341839	Mouse	PMID:18261938
Biological Process	GO:0032757	positive regulation of interleukin-8 production	NOD2	IMP		Human	PMID:24790089
Biological Process	GO:0046330	positive regulation of JNK cascade	NOD2	IDA		Human	PMID:17187069
Biological Process	GO:0046330	positive regulation of JNK cascade	Nod2	IDA		Mouse	PMID:18261938
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:15692051
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Nod2	IGI	MGI:MGI:1341839	Mouse	PMID:18261938
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Nod2	IMP	MGI:MGI:2680581	Mouse	PMID:15220916
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Nod2	IMP	MGI:MGI:2680581	Mouse	PMID:14560001
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Nod2	IDA		Mouse	PMID:18261938
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Nod2	IDA		Mouse	PMID:15220916
Biological Process	GO:0060907	positive regulation of macrophage cytokine production	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:18261938
Biological Process	GO:0043406	positive regulation of MAP kinase activity	Nod2	IDA		Mouse	MGI:MGI:4946442|PMID:21156799
Biological Process	GO:0043410	positive regulation of MAPK cascade	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:15692051
Biological Process	GO:0071639	positive regulation of monocyte chemotactic protein-1 production	Nod2	IMP		Mouse	MGI:MGI:5640951|PMID:16203728
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	NOD2	IDA		Human	PMID:12527755
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	NOD2	IDA		Human	PMID:11385577
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	NOD2	IMP		Human	PMID:16203728
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	NOD2	IDA		Human	PMID:21887730
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	NOD2	IMP		Human	PMID:24790089
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	Nod2	IMP	MGI:MGI:2680581	Mouse	PMID:15220916
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	NOD2	IMP		Human	PMID:25093298
Biological Process	GO:1901224	positive regulation of NIK/NF-kappaB signaling	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:22033934
Biological Process	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process	Nod2	IMP		Mouse	MGI:MGI:4946442|PMID:21156799
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	Nod2	IDA		Mouse	MGI:MGI:4946442|PMID:21156799
Biological Process	GO:0051353	positive regulation of oxidoreductase activity	Nod2	IDA		Mouse	MGI:MGI:4946442|PMID:21156799
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:15692051
Biological Process	GO:0050766	positive regulation of phagocytosis	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:19139201
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	Nod2	IMP		Mouse	MGI:MGI:4946442|PMID:21156799
Biological Process	GO:2000363	positive regulation of prostaglandin-E synthase activity	Nod2	IDA		Mouse	MGI:MGI:4946442|PMID:21156799
Biological Process	GO:0060585	positive regulation of prostaglandin-endoperoxide synthase activity	Nod2	IDA		Mouse	MGI:MGI:4946442|PMID:21156799
Biological Process	GO:1902523	positive regulation of protein K63-linked ubiquitination	NOD2	IMP		Human	PMID:25891078
Biological Process	GO:0031398	positive regulation of protein ubiquitination	Nod2	IDA		Mouse	MGI:MGI:4441121|PMID:15620648
Biological Process	GO:0032874	positive regulation of stress-activated MAPK cascade	NOD2	IDA		Human	PMID:17187069
Biological Process	GO:0032874	positive regulation of stress-activated MAPK cascade	Nod2	IDA		Mouse	PMID:18261938
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	NOD2	IDA		Human	PMID:21887730
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	NOD2	IDA		Human	PMID:17187069
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	NOD2	IMP		Human	PMID:21040358
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Nod2	IGI	MGI:MGI:1341839	Mouse	PMID:18261938
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:18261938
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Nod2	IDA		Mouse	PMID:18261938
Biological Process	GO:0032760	positive regulation of tumor necrosis factor production	Nod2	IMP	MGI:MGI:2680581	Mouse	PMID:15220916
Biological Process	GO:0002830	positive regulation of type 2 immune response	NOD2	IMP		Human	PMID:21172192
Biological Process	GO:1904417	positive regulation of xenophagy	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:22033934
Biological Process	GO:0006355	regulation of DNA-templated transcription	nod2	IGI	ZFIN:ZDB-GENE-081104-438	Zfish	PMID:27235368
Biological Process	GO:0006355	regulation of DNA-templated transcription	nod2	IGI	ZFIN:ZDB-GENE-030902-3	Zfish	PMID:27235368
Biological Process	GO:0006355	regulation of DNA-templated transcription	nod2	IGI	ZFIN:ZDB-GENE-070112-1402	Zfish	PMID:27235368
Biological Process	GO:0006355	regulation of DNA-templated transcription	nod2	IDA		Zfish	PMID:27235368
Biological Process	GO:0010468	regulation of gene expression	nod2	IDA		Zfish	PMID:28555019
Biological Process	GO:0050727	regulation of inflammatory response	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:19218085
Biological Process	GO:0090022	regulation of neutrophil chemotaxis	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:19139201
Biological Process	GO:0009617	response to bacterium	nod2	IDA		Zfish	PMID:27235368
Biological Process	GO:0043330	response to exogenous dsRNA	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:15692051
Biological Process	GO:0032496	response to lipopolysaccharide	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:15692051
Biological Process	GO:0032496	response to lipopolysaccharide	Nod2	IMP	MGI:MGI:2680581	Mouse	PMID:14560001
Biological Process	GO:0032495	response to muramyl dipeptide	NOD2	IDA		Human	PMID:15998797
Biological Process	GO:0032495	response to muramyl dipeptide	NOD2	IDA		Human	PMID:16414084
Biological Process	GO:0032495	response to muramyl dipeptide	NOD2	IMP		Human	PMID:24790089
Biological Process	GO:0032495	response to muramyl dipeptide	Nod2	IDA		Mouse	MGI:MGI:4943384|PMID:18511561
Biological Process	GO:0032495	response to muramyl dipeptide	Nod2	IMP	MGI:MGI:2680581	Mouse	PMID:15220916
Biological Process	GO:0032495	response to muramyl dipeptide	Nod2	IDA		Mouse	PMID:15220916
Biological Process	GO:0032495	response to muramyl dipeptide	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:15692051
Biological Process	GO:0032495	response to muramyl dipeptide	Nod2	IMP	MGI:MGI:2680581	Mouse	PMID:14560001
Biological Process	GO:0032495	response to muramyl dipeptide	Nod2	IDA		Rat	PMID:16973131|RGD:1643119
Biological Process	GO:0007584	response to nutrient	Nod2	IEP		Rat	PMID:21057821|RGD:5131436
Biological Process	GO:0032494	response to peptidoglycan	Nod2	IDA		Mouse	PMID:15220916
Biological Process	GO:0032494	response to peptidoglycan	Nod2	IMP	MGI:MGI:2680581	Mouse	PMID:15220916
Biological Process	GO:0051403	stress-activated MAPK cascade	Nod2	IDA		Mouse	PMID:18261938
Biological Process	GO:0034134	toll-like receptor 2 signaling pathway	Nod2	IMP	MGI:MGI:2680581	Mouse	PMID:15220916
Biological Process	GO:0032640	tumor necrosis factor production	Nod2	IGI	MGI:MGI:1341839	Mouse	PMID:18261938
Biological Process	GO:0032640	tumor necrosis factor production	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:18261938
Biological Process	GO:0032640	tumor necrosis factor production	Nod2	IDA		Mouse	PMID:18261938
Biological Process	GO:0032640	tumor necrosis factor production	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:19139201
Biological Process	GO:0032609	type II interferon production	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:19139201
Biological Process	GO:0032609	type II interferon production	Nod2	IMP	MGI:MGI:2680581	Mouse	PMID:15220916
Biological Process	GO:0060333	type II interferon-mediated signaling pathway	nod2	IDA		Zfish	PMID:28555019
Biological Process	GO:0060333	type II interferon-mediated signaling pathway	nod2	IMP	ZFIN:ZDB-MRPHLNO-180129-1	Zfish	PMID:28555019
Biological Process	GO:0098792	xenophagy	Nod2	IMP	MGI:MGI:3529594	Mouse	PMID:22033934

Gene Ontology Evidence Code Abbreviations:

  EXP Inferred from experiment

  IDA Inferred from direct assay

  IEP Inferred from expression pattern

  IGI Inferred from genetic interaction

  IMP Inferred from mutant phenotype

  IPI Inferred from physical interaction

  HTP Inferred from High Throughput Experiment

  HDA Inferred from High Throughput Direct Assay

  HMP Inferred from High Throughput Mutant Phenotype

  HGI Inferred from High Throughput Genetic Interaction

  HEP Inferred from High Throughput Expression Pattern