| GO term: | ERK1 and ERK2 cascade |
| Synonym: | ERK1/2 cascade |
| Synonym: | ERK1 and ERK2 signaling pathway |
| Synonym: | ERK1 and ERK2 signalling pathway |
| Synonym: | ERK1 cascade |
| Synonym: | ERK2 cascade |
| Synonym: | ERK cascade |
| Synonym: | extracellular signal-regulated kinase 1/2 cascade |
| Synonym: | extracellular signal-regulated kinase 1/2 (ERK1/2) cascade |
| Synonym: | MAPK1 cascade |
| Synonym: | MAPK3 cascade |
| GO id: | GO:0070371 |
| Definition: | An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. |
| Comments | Note that this MAPKKK cascade is commonly referred to as the ERK pathway in the literature, but involves only ERK1 or ERK2, not other ERK kinases. |
| Number of paths to term: | 10 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionintracellular signal transductionintracellular protein kinase cascadeMAPK cascadeERK1 and ERK2 cascade [GO:0070371] (141 genes, 170 annotations)negative regulation of ERK1 and ERK2 cascadepositive regulation of ERK1 and ERK2 cascade +regulation of ERK1 and ERK2 cascade +ERK5 cascade +MAPK cascade involved in cell wall biogenesis +MAPK cascade involved in conjugation with cellular fusion +MAPK cascade involved in innate immune response +MAPK cascade involved in osmosensory signaling pathway +MAPK import into nucleus +negative regulation of MAPK cascade +positive regulation of MAPK cascade +regulation of MAPK cascade +stress-activated MAPK cascade +biological_processcellular processregulation of cellular processsignal transductionintracellular signal transductionintracellular protein kinase cascadeMAPK cascadeERK1 and ERK2 cascade [GO:0070371] (141 genes, 170 annotations)negative regulation of ERK1 and ERK2 cascadepositive regulation of ERK1 and ERK2 cascade +regulation of ERK1 and ERK2 cascade +ERK5 cascade +MAPK cascade involved in cell wall biogenesis +MAPK cascade involved in conjugation with cellular fusion +MAPK cascade involved in innate immune response +MAPK cascade involved in osmosensory signaling pathway +MAPK import into nucleus +negative regulation of MAPK cascade +positive regulation of MAPK cascade +regulation of MAPK cascade +stress-activated MAPK cascade +biological_processcellular processsingle-organism cellular processcell communicationsignal transductionintracellular signal transductionintracellular protein kinase cascadeMAPK cascadeERK1 and ERK2 cascade [GO:0070371] (141 genes, 170 annotations)negative regulation of ERK1 and ERK2 cascadepositive regulation of ERK1 and ERK2 cascade +regulation of ERK1 and ERK2 cascade +ERK5 cascade +MAPK cascade involved in cell wall biogenesis +MAPK cascade involved in conjugation with cellular fusion +MAPK cascade involved in innate immune response +MAPK cascade involved in osmosensory signaling pathway +MAPK import into nucleus +negative regulation of MAPK cascade +positive regulation of MAPK cascade +regulation of MAPK cascade +stress-activated MAPK cascade +biological_processcellular processsingle-organism cellular processcellular response to stimulussignal transductionintracellular signal transductionintracellular protein kinase cascadeMAPK cascadeERK1 and ERK2 cascade [GO:0070371] (141 genes, 170 annotations)negative regulation of ERK1 and ERK2 cascadepositive regulation of ERK1 and ERK2 cascade +regulation of ERK1 and ERK2 cascade +ERK5 cascade +MAPK cascade involved in cell wall biogenesis +MAPK cascade involved in conjugation with cellular fusion +MAPK cascade involved in innate immune response +MAPK cascade involved in osmosensory signaling pathway +MAPK import into nucleus +negative regulation of MAPK cascade +positive regulation of MAPK cascade +regulation of MAPK cascade +stress-activated MAPK cascade +biological_processregulation of biological processregulation of cellular processsignal transductionintracellular signal transductionintracellular protein kinase cascadeMAPK cascadeERK1 and ERK2 cascade [GO:0070371] (141 genes, 170 annotations)negative regulation of ERK1 and ERK2 cascadepositive regulation of ERK1 and ERK2 cascade +regulation of ERK1 and ERK2 cascade +ERK5 cascade +MAPK cascade involved in cell wall biogenesis +MAPK cascade involved in conjugation with cellular fusion +MAPK cascade involved in innate immune response +MAPK cascade involved in osmosensory signaling pathway +MAPK import into nucleus +negative regulation of MAPK cascade +positive regulation of MAPK cascade +regulation of MAPK cascade +stress-activated MAPK cascade +biological_processresponse to stimuluscellular response to stimulussignal transductionintracellular signal transductionintracellular protein kinase cascadeMAPK cascadeERK1 and ERK2 cascade [GO:0070371] (141 genes, 170 annotations)negative regulation of ERK1 and ERK2 cascadepositive regulation of ERK1 and ERK2 cascade +regulation of ERK1 and ERK2 cascade +ERK5 cascade +MAPK cascade involved in cell wall biogenesis +MAPK cascade involved in conjugation with cellular fusion +MAPK cascade involved in innate immune response +MAPK cascade involved in osmosensory signaling pathway +MAPK import into nucleus +negative regulation of MAPK cascade +positive regulation of MAPK cascade +regulation of MAPK cascade +stress-activated MAPK cascade +biological_processsignalingsingle organism signalingsignal transductionintracellular signal transductionintracellular protein kinase cascadeMAPK cascadeERK1 and ERK2 cascade [GO:0070371] (141 genes, 170 annotations)negative regulation of ERK1 and ERK2 cascadepositive regulation of ERK1 and ERK2 cascade +regulation of ERK1 and ERK2 cascade +ERK5 cascade +MAPK cascade involved in cell wall biogenesis +MAPK cascade involved in conjugation with cellular fusion +MAPK cascade involved in innate immune response +MAPK cascade involved in osmosensory signaling pathway +MAPK import into nucleus +negative regulation of MAPK cascade +positive regulation of MAPK cascade +regulation of MAPK cascade +stress-activated MAPK cascade +biological_processsingle-organism processsingle organism signalingsignal transductionintracellular signal transductionintracellular protein kinase cascadeMAPK cascadeERK1 and ERK2 cascade [GO:0070371] (141 genes, 170 annotations)negative regulation of ERK1 and ERK2 cascadepositive regulation of ERK1 and ERK2 cascade +regulation of ERK1 and ERK2 cascade +ERK5 cascade +MAPK cascade involved in cell wall biogenesis +MAPK cascade involved in conjugation with cellular fusion +MAPK cascade involved in innate immune response +MAPK cascade involved in osmosensory signaling pathway +MAPK import into nucleus +negative regulation of MAPK cascade +positive regulation of MAPK cascade +regulation of MAPK cascade +stress-activated MAPK cascade +biological_processsingle-organism processsingle-organism cellular processcell communicationsignal transductionintracellular signal transductionintracellular protein kinase cascadeMAPK cascadeERK1 and ERK2 cascade [GO:0070371] (141 genes, 170 annotations)negative regulation of ERK1 and ERK2 cascadepositive regulation of ERK1 and ERK2 cascade +regulation of ERK1 and ERK2 cascade +ERK5 cascade +MAPK cascade involved in cell wall biogenesis +MAPK cascade involved in conjugation with cellular fusion +MAPK cascade involved in innate immune response +MAPK cascade involved in osmosensory signaling pathway +MAPK import into nucleus +negative regulation of MAPK cascade +positive regulation of MAPK cascade +regulation of MAPK cascade +stress-activated MAPK cascade +biological_processsingle-organism processsingle-organism cellular processcellular response to stimulussignal transductionintracellular signal transductionintracellular protein kinase cascadeMAPK cascadeERK1 and ERK2 cascade [GO:0070371] (141 genes, 170 annotations)negative regulation of ERK1 and ERK2 cascadepositive regulation of ERK1 and ERK2 cascade +regulation of ERK1 and ERK2 cascade +ERK5 cascade +MAPK cascade involved in cell wall biogenesis +MAPK cascade involved in conjugation with cellular fusion +MAPK cascade involved in innate immune response +MAPK cascade involved in osmosensory signaling pathway +MAPK import into nucleus +negative regulation of MAPK cascade +positive regulation of MAPK cascade +regulation of MAPK cascade +stress-activated MAPK cascade +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 06/05/2013 MGI 5.13 |
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