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Gene Ontology Browser
Term Detail
GO term:ERK1 and ERK2 cascade
Synonym: ERK1/2 cascade
Synonym: ERK1 and ERK2 signaling pathway
Synonym: ERK1 and ERK2 signalling pathway
Synonym: ERK1 cascade
Synonym: ERK2 cascade
Synonym: ERK cascade
Synonym: extracellular signal-regulated kinase 1/2 cascade
Synonym: extracellular signal-regulated kinase 1/2 (ERK1/2) cascade
Synonym: MAPK1 cascade
Synonym: MAPK3 cascade
GO id:GO:0070371
Definition:An intracellular protein kinase cascade containing at least ERK1 or ERK2 (MAPKs), a MEK (a MAPKK) and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
CommentsNote that this MAPKKK cascade is commonly referred to as the ERK pathway in the literature, but involves only ERK1 or ERK2, not other ERK kinases.
Number of paths to term: 24

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-aintracellular signal transduction
                                                        is-aMAPK cascade
                                                                is-aERK1 and ERK2 cascade [GO:0070371] (181 genes, 223 annotations)
                                                                        negatively-regulatesnegative regulation of ERK1 and ERK2 cascade
                                                                        positively-regulatespositive regulation of ERK1 and ERK2 cascade +
                                                                        regulatesregulation of ERK1 and ERK2 cascade +
                                                                is-aERK5 cascade +
                                                                is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                                is-aMAPK cascade involved in conjugation with cellular fusion +
                                                                is-aMAPK cascade involved in innate immune response +
                                                                is-aMAPK cascade involved in osmosensory signaling pathway +
                                                                part-ofMAPK import into nucleus +
                                                                negatively-regulatesnegative regulation of MAPK cascade +
                                                                positively-regulatespositive regulation of MAPK cascade +
                                                                regulatesregulation of MAPK cascade +
                                                                is-astress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-asignal transduction by phosphorylation
                                                        is-aMAPK cascade
                                                                is-aERK1 and ERK2 cascade [GO:0070371] (181 genes, 223 annotations)
                                                                        negatively-regulatesnegative regulation of ERK1 and ERK2 cascade
                                                                        positively-regulatespositive regulation of ERK1 and ERK2 cascade +
                                                                        regulatesregulation of ERK1 and ERK2 cascade +
                                                                is-aERK5 cascade +
                                                                is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                                is-aMAPK cascade involved in conjugation with cellular fusion +
                                                                is-aMAPK cascade involved in innate immune response +
                                                                is-aMAPK cascade involved in osmosensory signaling pathway +
                                                                part-ofMAPK import into nucleus +
                                                                negatively-regulatesnegative regulation of MAPK cascade +
                                                                positively-regulatespositive regulation of MAPK cascade +
                                                                regulatesregulation of MAPK cascade +
                                                                is-astress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular metabolic process
                                is-aphosphorus metabolic process
                                        is-aphosphate-containing compound metabolic process
                                                is-aphosphorylation
                                                        is-asignal transduction by phosphorylation
                                                                is-aMAPK cascade
                                                                        is-aERK1 and ERK2 cascade [GO:0070371] (181 genes, 223 annotations)
                                                                                negatively-regulatesnegative regulation of ERK1 and ERK2 cascade
                                                                                positively-regulatespositive regulation of ERK1 and ERK2 cascade +
                                                                                regulatesregulation of ERK1 and ERK2 cascade +
                                                                        is-aERK5 cascade +
                                                                        is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                                        is-aMAPK cascade involved in conjugation with cellular fusion +
                                                                        is-aMAPK cascade involved in innate immune response +
                                                                        is-aMAPK cascade involved in osmosensory signaling pathway +
                                                                        part-ofMAPK import into nucleus +
                                                                        negatively-regulatesnegative regulation of MAPK cascade +
                                                                        positively-regulatespositive regulation of MAPK cascade +
                                                                        regulatesregulation of MAPK cascade +
                                                                        is-astress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-aMAPK cascade
                                                        is-aERK1 and ERK2 cascade [GO:0070371] (181 genes, 223 annotations)
                                                                negatively-regulatesnegative regulation of ERK1 and ERK2 cascade
                                                                positively-regulatespositive regulation of ERK1 and ERK2 cascade +
                                                                regulatesregulation of ERK1 and ERK2 cascade +
                                                        is-aERK5 cascade +
                                                        is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                        is-aMAPK cascade involved in conjugation with cellular fusion +
                                                        is-aMAPK cascade involved in innate immune response +
                                                        is-aMAPK cascade involved in osmosensory signaling pathway +
                                                        part-ofMAPK import into nucleus +
                                                        negatively-regulatesnegative regulation of MAPK cascade +
                                                        positively-regulatespositive regulation of MAPK cascade +
                                                        regulatesregulation of MAPK cascade +
                                                        is-astress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-asignal transduction by phosphorylation
                                                is-aMAPK cascade
                                                        is-aERK1 and ERK2 cascade [GO:0070371] (181 genes, 223 annotations)
                                                                negatively-regulatesnegative regulation of ERK1 and ERK2 cascade
                                                                positively-regulatespositive regulation of ERK1 and ERK2 cascade +
                                                                regulatesregulation of ERK1 and ERK2 cascade +
                                                        is-aERK5 cascade +
                                                        is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                        is-aMAPK cascade involved in conjugation with cellular fusion +
                                                        is-aMAPK cascade involved in innate immune response +
                                                        is-aMAPK cascade involved in osmosensory signaling pathway +
                                                        part-ofMAPK import into nucleus +
                                                        negatively-regulatesnegative regulation of MAPK cascade +
                                                        positively-regulatespositive regulation of MAPK cascade +
                                                        regulatesregulation of MAPK cascade +
                                                        is-astress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-aMAPK cascade
                                                        is-aERK1 and ERK2 cascade [GO:0070371] (181 genes, 223 annotations)
                                                                negatively-regulatesnegative regulation of ERK1 and ERK2 cascade
                                                                positively-regulatespositive regulation of ERK1 and ERK2 cascade +
                                                                regulatesregulation of ERK1 and ERK2 cascade +
                                                        is-aERK5 cascade +
                                                        is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                        is-aMAPK cascade involved in conjugation with cellular fusion +
                                                        is-aMAPK cascade involved in innate immune response +
                                                        is-aMAPK cascade involved in osmosensory signaling pathway +
                                                        part-ofMAPK import into nucleus +
                                                        negatively-regulatesnegative regulation of MAPK cascade +
                                                        positively-regulatespositive regulation of MAPK cascade +
                                                        regulatesregulation of MAPK cascade +
                                                        is-astress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-asignal transduction by phosphorylation
                                                is-aMAPK cascade
                                                        is-aERK1 and ERK2 cascade [GO:0070371] (181 genes, 223 annotations)
                                                                negatively-regulatesnegative regulation of ERK1 and ERK2 cascade
                                                                positively-regulatespositive regulation of ERK1 and ERK2 cascade +
                                                                regulatesregulation of ERK1 and ERK2 cascade +
                                                        is-aERK5 cascade +
                                                        is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                        is-aMAPK cascade involved in conjugation with cellular fusion +
                                                        is-aMAPK cascade involved in innate immune response +
                                                        is-aMAPK cascade involved in osmosensory signaling pathway +
                                                        part-ofMAPK import into nucleus +
                                                        negatively-regulatesnegative regulation of MAPK cascade +
                                                        positively-regulatespositive regulation of MAPK cascade +
                                                        regulatesregulation of MAPK cascade +
                                                        is-astress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aintracellular signal transduction
                                                        is-aMAPK cascade
                                                                is-aERK1 and ERK2 cascade [GO:0070371] (181 genes, 223 annotations)
                                                                        negatively-regulatesnegative regulation of ERK1 and ERK2 cascade
                                                                        positively-regulatespositive regulation of ERK1 and ERK2 cascade +
                                                                        regulatesregulation of ERK1 and ERK2 cascade +
                                                                is-aERK5 cascade +
                                                                is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                                is-aMAPK cascade involved in conjugation with cellular fusion +
                                                                is-aMAPK cascade involved in innate immune response +
                                                                is-aMAPK cascade involved in osmosensory signaling pathway +
                                                                part-ofMAPK import into nucleus +
                                                                negatively-regulatesnegative regulation of MAPK cascade +
                                                                positively-regulatespositive regulation of MAPK cascade +
                                                                regulatesregulation of MAPK cascade +
                                                                is-astress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-asignal transduction by phosphorylation
                                                        is-aMAPK cascade
                                                                is-aERK1 and ERK2 cascade [GO:0070371] (181 genes, 223 annotations)
                                                                        negatively-regulatesnegative regulation of ERK1 and ERK2 cascade
                                                                        positively-regulatespositive regulation of ERK1 and ERK2 cascade +
                                                                        regulatesregulation of ERK1 and ERK2 cascade +
                                                                is-aERK5 cascade +
                                                                is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                                is-aMAPK cascade involved in conjugation with cellular fusion +
                                                                is-aMAPK cascade involved in innate immune response +
                                                                is-aMAPK cascade involved in osmosensory signaling pathway +
                                                                part-ofMAPK import into nucleus +
                                                                negatively-regulatesnegative regulation of MAPK cascade +
                                                                positively-regulatespositive regulation of MAPK cascade +
                                                                regulatesregulation of MAPK cascade +
                                                                is-astress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-asignal transduction by phosphorylation
                                        is-aMAPK cascade
                                                is-aERK1 and ERK2 cascade [GO:0070371] (181 genes, 223 annotations)
                                                        negatively-regulatesnegative regulation of ERK1 and ERK2 cascade
                                                        positively-regulatespositive regulation of ERK1 and ERK2 cascade +
                                                        regulatesregulation of ERK1 and ERK2 cascade +
                                                is-aERK5 cascade +
                                                is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                is-aMAPK cascade involved in conjugation with cellular fusion +
                                                is-aMAPK cascade involved in innate immune response +
                                                is-aMAPK cascade involved in osmosensory signaling pathway +
                                                part-ofMAPK import into nucleus +
                                                negatively-regulatesnegative regulation of MAPK cascade +
                                                positively-regulatespositive regulation of MAPK cascade +
                                                regulatesregulation of MAPK cascade +
                                                is-astress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-acellular metabolic process
                                is-aphosphorus metabolic process
                                        is-aphosphate-containing compound metabolic process
                                                is-aphosphorylation
                                                        is-asignal transduction by phosphorylation
                                                                is-aMAPK cascade
                                                                        is-aERK1 and ERK2 cascade [GO:0070371] (181 genes, 223 annotations)
                                                                                negatively-regulatesnegative regulation of ERK1 and ERK2 cascade
                                                                                positively-regulatespositive regulation of ERK1 and ERK2 cascade +
                                                                                regulatesregulation of ERK1 and ERK2 cascade +
                                                                        is-aERK5 cascade +
                                                                        is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                                        is-aMAPK cascade involved in conjugation with cellular fusion +
                                                                        is-aMAPK cascade involved in innate immune response +
                                                                        is-aMAPK cascade involved in osmosensory signaling pathway +
                                                                        part-ofMAPK import into nucleus +
                                                                        negatively-regulatesnegative regulation of MAPK cascade +
                                                                        positively-regulatespositive regulation of MAPK cascade +
                                                                        regulatesregulation of MAPK cascade +
                                                                        is-astress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-asingle-organism metabolic process
                                is-asignal transduction by phosphorylation
                                        is-aMAPK cascade
                                                is-aERK1 and ERK2 cascade [GO:0070371] (181 genes, 223 annotations)
                                                        negatively-regulatesnegative regulation of ERK1 and ERK2 cascade
                                                        positively-regulatespositive regulation of ERK1 and ERK2 cascade +
                                                        regulatesregulation of ERK1 and ERK2 cascade +
                                                is-aERK5 cascade +
                                                is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                is-aMAPK cascade involved in conjugation with cellular fusion +
                                                is-aMAPK cascade involved in innate immune response +
                                                is-aMAPK cascade involved in osmosensory signaling pathway +
                                                part-ofMAPK import into nucleus +
                                                negatively-regulatesnegative regulation of MAPK cascade +
                                                positively-regulatespositive regulation of MAPK cascade +
                                                regulatesregulation of MAPK cascade +
                                                is-astress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-aMAPK cascade
                                                        is-aERK1 and ERK2 cascade [GO:0070371] (181 genes, 223 annotations)
                                                                negatively-regulatesnegative regulation of ERK1 and ERK2 cascade
                                                                positively-regulatespositive regulation of ERK1 and ERK2 cascade +
                                                                regulatesregulation of ERK1 and ERK2 cascade +
                                                        is-aERK5 cascade +
                                                        is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                        is-aMAPK cascade involved in conjugation with cellular fusion +
                                                        is-aMAPK cascade involved in innate immune response +
                                                        is-aMAPK cascade involved in osmosensory signaling pathway +
                                                        part-ofMAPK import into nucleus +
                                                        negatively-regulatesnegative regulation of MAPK cascade +
                                                        positively-regulatespositive regulation of MAPK cascade +
                                                        regulatesregulation of MAPK cascade +
                                                        is-astress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-asignal transduction by phosphorylation
                                                is-aMAPK cascade
                                                        is-aERK1 and ERK2 cascade [GO:0070371] (181 genes, 223 annotations)
                                                                negatively-regulatesnegative regulation of ERK1 and ERK2 cascade
                                                                positively-regulatespositive regulation of ERK1 and ERK2 cascade +
                                                                regulatesregulation of ERK1 and ERK2 cascade +
                                                        is-aERK5 cascade +
                                                        is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                        is-aMAPK cascade involved in conjugation with cellular fusion +
                                                        is-aMAPK cascade involved in innate immune response +
                                                        is-aMAPK cascade involved in osmosensory signaling pathway +
                                                        part-ofMAPK import into nucleus +
                                                        negatively-regulatesnegative regulation of MAPK cascade +
                                                        positively-regulatespositive regulation of MAPK cascade +
                                                        regulatesregulation of MAPK cascade +
                                                        is-astress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-aMAPK cascade
                                                        is-aERK1 and ERK2 cascade [GO:0070371] (181 genes, 223 annotations)
                                                                negatively-regulatesnegative regulation of ERK1 and ERK2 cascade
                                                                positively-regulatespositive regulation of ERK1 and ERK2 cascade +
                                                                regulatesregulation of ERK1 and ERK2 cascade +
                                                        is-aERK5 cascade +
                                                        is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                        is-aMAPK cascade involved in conjugation with cellular fusion +
                                                        is-aMAPK cascade involved in innate immune response +
                                                        is-aMAPK cascade involved in osmosensory signaling pathway +
                                                        part-ofMAPK import into nucleus +
                                                        negatively-regulatesnegative regulation of MAPK cascade +
                                                        positively-regulatespositive regulation of MAPK cascade +
                                                        regulatesregulation of MAPK cascade +
                                                        is-astress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-asignal transduction by phosphorylation
                                                is-aMAPK cascade
                                                        is-aERK1 and ERK2 cascade [GO:0070371] (181 genes, 223 annotations)
                                                                negatively-regulatesnegative regulation of ERK1 and ERK2 cascade
                                                                positively-regulatespositive regulation of ERK1 and ERK2 cascade +
                                                                regulatesregulation of ERK1 and ERK2 cascade +
                                                        is-aERK5 cascade +
                                                        is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                        is-aMAPK cascade involved in conjugation with cellular fusion +
                                                        is-aMAPK cascade involved in innate immune response +
                                                        is-aMAPK cascade involved in osmosensory signaling pathway +
                                                        part-ofMAPK import into nucleus +
                                                        negatively-regulatesnegative regulation of MAPK cascade +
                                                        positively-regulatespositive regulation of MAPK cascade +
                                                        regulatesregulation of MAPK cascade +
                                                        is-astress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aintracellular signal transduction
                                                is-aMAPK cascade
                                                        is-aERK1 and ERK2 cascade [GO:0070371] (181 genes, 223 annotations)
                                                                negatively-regulatesnegative regulation of ERK1 and ERK2 cascade
                                                                positively-regulatespositive regulation of ERK1 and ERK2 cascade +
                                                                regulatesregulation of ERK1 and ERK2 cascade +
                                                        is-aERK5 cascade +
                                                        is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                        is-aMAPK cascade involved in conjugation with cellular fusion +
                                                        is-aMAPK cascade involved in innate immune response +
                                                        is-aMAPK cascade involved in osmosensory signaling pathway +
                                                        part-ofMAPK import into nucleus +
                                                        negatively-regulatesnegative regulation of MAPK cascade +
                                                        positively-regulatespositive regulation of MAPK cascade +
                                                        regulatesregulation of MAPK cascade +
                                                        is-astress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-asignal transduction by phosphorylation
                                                is-aMAPK cascade
                                                        is-aERK1 and ERK2 cascade [GO:0070371] (181 genes, 223 annotations)
                                                                negatively-regulatesnegative regulation of ERK1 and ERK2 cascade
                                                                positively-regulatespositive regulation of ERK1 and ERK2 cascade +
                                                                regulatesregulation of ERK1 and ERK2 cascade +
                                                        is-aERK5 cascade +
                                                        is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                        is-aMAPK cascade involved in conjugation with cellular fusion +
                                                        is-aMAPK cascade involved in innate immune response +
                                                        is-aMAPK cascade involved in osmosensory signaling pathway +
                                                        part-ofMAPK import into nucleus +
                                                        negatively-regulatesnegative regulation of MAPK cascade +
                                                        positively-regulatespositive regulation of MAPK cascade +
                                                        regulatesregulation of MAPK cascade +
                                                        is-astress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aintracellular signal transduction
                                                is-aMAPK cascade
                                                        is-aERK1 and ERK2 cascade [GO:0070371] (181 genes, 223 annotations)
                                                                negatively-regulatesnegative regulation of ERK1 and ERK2 cascade
                                                                positively-regulatespositive regulation of ERK1 and ERK2 cascade +
                                                                regulatesregulation of ERK1 and ERK2 cascade +
                                                        is-aERK5 cascade +
                                                        is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                        is-aMAPK cascade involved in conjugation with cellular fusion +
                                                        is-aMAPK cascade involved in innate immune response +
                                                        is-aMAPK cascade involved in osmosensory signaling pathway +
                                                        part-ofMAPK import into nucleus +
                                                        negatively-regulatesnegative regulation of MAPK cascade +
                                                        positively-regulatespositive regulation of MAPK cascade +
                                                        regulatesregulation of MAPK cascade +
                                                        is-astress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-asignal transduction by phosphorylation
                                                is-aMAPK cascade
                                                        is-aERK1 and ERK2 cascade [GO:0070371] (181 genes, 223 annotations)
                                                                negatively-regulatesnegative regulation of ERK1 and ERK2 cascade
                                                                positively-regulatespositive regulation of ERK1 and ERK2 cascade +
                                                                regulatesregulation of ERK1 and ERK2 cascade +
                                                        is-aERK5 cascade +
                                                        is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                        is-aMAPK cascade involved in conjugation with cellular fusion +
                                                        is-aMAPK cascade involved in innate immune response +
                                                        is-aMAPK cascade involved in osmosensory signaling pathway +
                                                        part-ofMAPK import into nucleus +
                                                        negatively-regulatesnegative regulation of MAPK cascade +
                                                        positively-regulatespositive regulation of MAPK cascade +
                                                        regulatesregulation of MAPK cascade +
                                                        is-astress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aintracellular signal transduction
                                                        is-aMAPK cascade
                                                                is-aERK1 and ERK2 cascade [GO:0070371] (181 genes, 223 annotations)
                                                                        negatively-regulatesnegative regulation of ERK1 and ERK2 cascade
                                                                        positively-regulatespositive regulation of ERK1 and ERK2 cascade +
                                                                        regulatesregulation of ERK1 and ERK2 cascade +
                                                                is-aERK5 cascade +
                                                                is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                                is-aMAPK cascade involved in conjugation with cellular fusion +
                                                                is-aMAPK cascade involved in innate immune response +
                                                                is-aMAPK cascade involved in osmosensory signaling pathway +
                                                                part-ofMAPK import into nucleus +
                                                                negatively-regulatesnegative regulation of MAPK cascade +
                                                                positively-regulatespositive regulation of MAPK cascade +
                                                                regulatesregulation of MAPK cascade +
                                                                is-astress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-asignal transduction by phosphorylation
                                                        is-aMAPK cascade
                                                                is-aERK1 and ERK2 cascade [GO:0070371] (181 genes, 223 annotations)
                                                                        negatively-regulatesnegative regulation of ERK1 and ERK2 cascade
                                                                        positively-regulatespositive regulation of ERK1 and ERK2 cascade +
                                                                        regulatesregulation of ERK1 and ERK2 cascade +
                                                                is-aERK5 cascade +
                                                                is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                                is-aMAPK cascade involved in conjugation with cellular fusion +
                                                                is-aMAPK cascade involved in innate immune response +
                                                                is-aMAPK cascade involved in osmosensory signaling pathway +
                                                                part-ofMAPK import into nucleus +
                                                                negatively-regulatesnegative regulation of MAPK cascade +
                                                                positively-regulatespositive regulation of MAPK cascade +
                                                                regulatesregulation of MAPK cascade +
                                                                is-astress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-asignal transduction by phosphorylation
                                        is-aMAPK cascade
                                                is-aERK1 and ERK2 cascade [GO:0070371] (181 genes, 223 annotations)
                                                        negatively-regulatesnegative regulation of ERK1 and ERK2 cascade
                                                        positively-regulatespositive regulation of ERK1 and ERK2 cascade +
                                                        regulatesregulation of ERK1 and ERK2 cascade +
                                                is-aERK5 cascade +
                                                is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                is-aMAPK cascade involved in conjugation with cellular fusion +
                                                is-aMAPK cascade involved in innate immune response +
                                                is-aMAPK cascade involved in osmosensory signaling pathway +
                                                part-ofMAPK import into nucleus +
                                                negatively-regulatesnegative regulation of MAPK cascade +
                                                positively-regulatespositive regulation of MAPK cascade +
                                                regulatesregulation of MAPK cascade +
                                                is-astress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism metabolic process
                                is-asignal transduction by phosphorylation
                                        is-aMAPK cascade
                                                is-aERK1 and ERK2 cascade [GO:0070371] (181 genes, 223 annotations)
                                                        negatively-regulatesnegative regulation of ERK1 and ERK2 cascade
                                                        positively-regulatespositive regulation of ERK1 and ERK2 cascade +
                                                        regulatesregulation of ERK1 and ERK2 cascade +
                                                is-aERK5 cascade +
                                                is-aMAPK cascade involved in cell wall organization or biogenesis +
                                                is-aMAPK cascade involved in conjugation with cellular fusion +
                                                is-aMAPK cascade involved in innate immune response +
                                                is-aMAPK cascade involved in osmosensory signaling pathway +
                                                part-ofMAPK import into nucleus +
                                                negatively-regulatesnegative regulation of MAPK cascade +
                                                positively-regulatespositive regulation of MAPK cascade +
                                                regulatesregulation of MAPK cascade +
                                                is-astress-activated MAPK cascade +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory