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Gene Ontology Browser
Term Detail
GO term:negative regulation of tumor necrosis factor production
Synonym: down regulation of tumor necrosis factor production
Synonym: down-regulation of tumor necrosis factor production
Synonym: downregulation of tumor necrosis factor production
Synonym: inhibition of tumor necrosis factor production
Synonym: negative regulation TNF-alpha production
Synonym: negative regulation TNF production
Synonym: negative regulation tumor necrosis factor-alpha production
GO id:GO:0032720
Definition:Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.
CommentsNote that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF').
Number of paths to term: 31

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-anegative regulation of biological process
                                        is-anegative regulation of multicellular organismal process
                                                is-anegative regulation of cytokine production
                                                        is-anegative regulation of tumor necrosis factor superfamily cytokine production
                                                                is-anegative regulation of lymphotoxin A production +
                                                                is-anegative regulation of TRAIL production +
                                                                is-anegative regulation of tumor necrosis factor (ligand) superfamily member 11 production
                                                                is-anegative regulation of tumor necrosis factor production [GO:0032720] (35 genes, 40 annotations)
                                                                        is-anegative regulation of tumor necrosis factor biosynthetic process


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of multicellular organismal process
                                        is-anegative regulation of multicellular organismal process
                                                is-anegative regulation of cytokine production
                                                        is-anegative regulation of tumor necrosis factor superfamily cytokine production
                                                                is-anegative regulation of lymphotoxin A production +
                                                                is-anegative regulation of TRAIL production +
                                                                is-anegative regulation of tumor necrosis factor (ligand) superfamily member 11 production
                                                                is-anegative regulation of tumor necrosis factor production [GO:0032720] (35 genes, 40 annotations)
                                                                        is-anegative regulation of tumor necrosis factor biosynthetic process


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of multicellular organismal process
                                        is-aregulation of cytokine production
                                                is-anegative regulation of cytokine production
                                                        is-anegative regulation of tumor necrosis factor superfamily cytokine production
                                                                is-anegative regulation of lymphotoxin A production +
                                                                is-anegative regulation of TRAIL production +
                                                                is-anegative regulation of tumor necrosis factor (ligand) superfamily member 11 production
                                                                is-anegative regulation of tumor necrosis factor production [GO:0032720] (35 genes, 40 annotations)
                                                                        is-anegative regulation of tumor necrosis factor biosynthetic process


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of multicellular organismal process
                                        is-aregulation of cytokine production
                                                is-aregulation of tumor necrosis factor superfamily cytokine production
                                                        is-anegative regulation of tumor necrosis factor superfamily cytokine production
                                                                is-anegative regulation of lymphotoxin A production +
                                                                is-anegative regulation of TRAIL production +
                                                                is-anegative regulation of tumor necrosis factor (ligand) superfamily member 11 production
                                                                is-anegative regulation of tumor necrosis factor production [GO:0032720] (35 genes, 40 annotations)
                                                                        is-anegative regulation of tumor necrosis factor biosynthetic process


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of multicellular organismal process
                                        is-aregulation of cytokine production
                                                is-aregulation of tumor necrosis factor superfamily cytokine production
                                                        is-aregulation of tumor necrosis factor production
                                                                is-anegative regulation of tumor necrosis factor production [GO:0032720] (35 genes, 40 annotations)
                                                                        is-anegative regulation of tumor necrosis factor biosynthetic process
                                                                is-apositive regulation of tumor necrosis factor production +
                                                                is-aregulation of tumor necrosis factor biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-amulticellular organismal process
                        is-asingle-multicellular organism process
                                is-acytokine production
                                        negatively-regulatesnegative regulation of cytokine production
                                                is-anegative regulation of tumor necrosis factor superfamily cytokine production
                                                        is-anegative regulation of lymphotoxin A production +
                                                        is-anegative regulation of TRAIL production +
                                                        is-anegative regulation of tumor necrosis factor (ligand) superfamily member 11 production
                                                        is-anegative regulation of tumor necrosis factor production [GO:0032720] (35 genes, 40 annotations)
                                                                is-anegative regulation of tumor necrosis factor biosynthetic process


Gene_Ontology
        is-abiological_process
                is-amulticellular organismal process
                        is-asingle-multicellular organism process
                                is-acytokine production
                                        regulatesregulation of cytokine production
                                                is-anegative regulation of cytokine production
                                                        is-anegative regulation of tumor necrosis factor superfamily cytokine production
                                                                is-anegative regulation of lymphotoxin A production +
                                                                is-anegative regulation of TRAIL production +
                                                                is-anegative regulation of tumor necrosis factor (ligand) superfamily member 11 production
                                                                is-anegative regulation of tumor necrosis factor production [GO:0032720] (35 genes, 40 annotations)
                                                                        is-anegative regulation of tumor necrosis factor biosynthetic process


Gene_Ontology
        is-abiological_process
                is-amulticellular organismal process
                        is-asingle-multicellular organism process
                                is-acytokine production
                                        regulatesregulation of cytokine production
                                                is-aregulation of tumor necrosis factor superfamily cytokine production
                                                        is-anegative regulation of tumor necrosis factor superfamily cytokine production
                                                                is-anegative regulation of lymphotoxin A production +
                                                                is-anegative regulation of TRAIL production +
                                                                is-anegative regulation of tumor necrosis factor (ligand) superfamily member 11 production
                                                                is-anegative regulation of tumor necrosis factor production [GO:0032720] (35 genes, 40 annotations)
                                                                        is-anegative regulation of tumor necrosis factor biosynthetic process


Gene_Ontology
        is-abiological_process
                is-amulticellular organismal process
                        is-asingle-multicellular organism process
                                is-acytokine production
                                        regulatesregulation of cytokine production
                                                is-aregulation of tumor necrosis factor superfamily cytokine production
                                                        is-aregulation of tumor necrosis factor production
                                                                is-anegative regulation of tumor necrosis factor production [GO:0032720] (35 genes, 40 annotations)
                                                                        is-anegative regulation of tumor necrosis factor biosynthetic process
                                                                is-apositive regulation of tumor necrosis factor production +
                                                                is-aregulation of tumor necrosis factor biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-amulticellular organismal process
                        is-asingle-multicellular organism process
                                is-acytokine production
                                        is-atumor necrosis factor superfamily cytokine production
                                                negatively-regulatesnegative regulation of tumor necrosis factor superfamily cytokine production
                                                        is-anegative regulation of lymphotoxin A production +
                                                        is-anegative regulation of TRAIL production +
                                                        is-anegative regulation of tumor necrosis factor (ligand) superfamily member 11 production
                                                        is-anegative regulation of tumor necrosis factor production [GO:0032720] (35 genes, 40 annotations)
                                                                is-anegative regulation of tumor necrosis factor biosynthetic process


Gene_Ontology
        is-abiological_process
                is-amulticellular organismal process
                        is-asingle-multicellular organism process
                                is-acytokine production
                                        is-atumor necrosis factor superfamily cytokine production
                                                regulatesregulation of tumor necrosis factor superfamily cytokine production
                                                        is-anegative regulation of tumor necrosis factor superfamily cytokine production
                                                                is-anegative regulation of lymphotoxin A production +
                                                                is-anegative regulation of TRAIL production +
                                                                is-anegative regulation of tumor necrosis factor (ligand) superfamily member 11 production
                                                                is-anegative regulation of tumor necrosis factor production [GO:0032720] (35 genes, 40 annotations)
                                                                        is-anegative regulation of tumor necrosis factor biosynthetic process


Gene_Ontology
        is-abiological_process
                is-amulticellular organismal process
                        is-asingle-multicellular organism process
                                is-acytokine production
                                        is-atumor necrosis factor superfamily cytokine production
                                                regulatesregulation of tumor necrosis factor superfamily cytokine production
                                                        is-aregulation of tumor necrosis factor production
                                                                is-anegative regulation of tumor necrosis factor production [GO:0032720] (35 genes, 40 annotations)
                                                                        is-anegative regulation of tumor necrosis factor biosynthetic process
                                                                is-apositive regulation of tumor necrosis factor production +
                                                                is-aregulation of tumor necrosis factor biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-amulticellular organismal process
                        is-asingle-multicellular organism process
                                is-acytokine production
                                        is-atumor necrosis factor superfamily cytokine production
                                                is-atumor necrosis factor production
                                                        negatively-regulatesnegative regulation of tumor necrosis factor production [GO:0032720] (35 genes, 40 annotations)
                                                                is-anegative regulation of tumor necrosis factor biosynthetic process
                                                        positively-regulatespositive regulation of tumor necrosis factor production +
                                                        regulatesregulation of tumor necrosis factor production +
                                                        part-oftumor necrosis factor biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-amulticellular organismal process
                        is-asingle-multicellular organism process
                                is-acytokine production
                                        is-atumor necrosis factor superfamily cytokine production
                                                is-atumor necrosis factor production
                                                        regulatesregulation of tumor necrosis factor production
                                                                is-anegative regulation of tumor necrosis factor production [GO:0032720] (35 genes, 40 annotations)
                                                                        is-anegative regulation of tumor necrosis factor biosynthetic process
                                                                is-apositive regulation of tumor necrosis factor production +
                                                                is-aregulation of tumor necrosis factor biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-amulticellular organismal process
                        is-asingle-multicellular organism process
                                negatively-regulatesnegative regulation of multicellular organismal process
                                        is-anegative regulation of cytokine production
                                                is-anegative regulation of tumor necrosis factor superfamily cytokine production
                                                        is-anegative regulation of lymphotoxin A production +
                                                        is-anegative regulation of TRAIL production +
                                                        is-anegative regulation of tumor necrosis factor (ligand) superfamily member 11 production
                                                        is-anegative regulation of tumor necrosis factor production [GO:0032720] (35 genes, 40 annotations)
                                                                is-anegative regulation of tumor necrosis factor biosynthetic process


Gene_Ontology
        is-abiological_process
                negatively-regulatesnegative regulation of biological process
                        is-anegative regulation of multicellular organismal process
                                is-anegative regulation of cytokine production
                                        is-anegative regulation of tumor necrosis factor superfamily cytokine production
                                                is-anegative regulation of lymphotoxin A production +
                                                is-anegative regulation of TRAIL production +
                                                is-anegative regulation of tumor necrosis factor (ligand) superfamily member 11 production
                                                is-anegative regulation of tumor necrosis factor production [GO:0032720] (35 genes, 40 annotations)
                                                        is-anegative regulation of tumor necrosis factor biosynthetic process


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-anegative regulation of biological process
                                is-anegative regulation of multicellular organismal process
                                        is-anegative regulation of cytokine production
                                                is-anegative regulation of tumor necrosis factor superfamily cytokine production
                                                        is-anegative regulation of lymphotoxin A production +
                                                        is-anegative regulation of TRAIL production +
                                                        is-anegative regulation of tumor necrosis factor (ligand) superfamily member 11 production
                                                        is-anegative regulation of tumor necrosis factor production [GO:0032720] (35 genes, 40 annotations)
                                                                is-anegative regulation of tumor necrosis factor biosynthetic process


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of multicellular organismal process
                                is-anegative regulation of multicellular organismal process
                                        is-anegative regulation of cytokine production
                                                is-anegative regulation of tumor necrosis factor superfamily cytokine production
                                                        is-anegative regulation of lymphotoxin A production +
                                                        is-anegative regulation of TRAIL production +
                                                        is-anegative regulation of tumor necrosis factor (ligand) superfamily member 11 production
                                                        is-anegative regulation of tumor necrosis factor production [GO:0032720] (35 genes, 40 annotations)
                                                                is-anegative regulation of tumor necrosis factor biosynthetic process


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of multicellular organismal process
                                is-aregulation of cytokine production
                                        is-anegative regulation of cytokine production
                                                is-anegative regulation of tumor necrosis factor superfamily cytokine production
                                                        is-anegative regulation of lymphotoxin A production +
                                                        is-anegative regulation of TRAIL production +
                                                        is-anegative regulation of tumor necrosis factor (ligand) superfamily member 11 production
                                                        is-anegative regulation of tumor necrosis factor production [GO:0032720] (35 genes, 40 annotations)
                                                                is-anegative regulation of tumor necrosis factor biosynthetic process


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of multicellular organismal process
                                is-aregulation of cytokine production
                                        is-aregulation of tumor necrosis factor superfamily cytokine production
                                                is-anegative regulation of tumor necrosis factor superfamily cytokine production
                                                        is-anegative regulation of lymphotoxin A production +
                                                        is-anegative regulation of TRAIL production +
                                                        is-anegative regulation of tumor necrosis factor (ligand) superfamily member 11 production
                                                        is-anegative regulation of tumor necrosis factor production [GO:0032720] (35 genes, 40 annotations)
                                                                is-anegative regulation of tumor necrosis factor biosynthetic process


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of multicellular organismal process
                                is-aregulation of cytokine production
                                        is-aregulation of tumor necrosis factor superfamily cytokine production
                                                is-aregulation of tumor necrosis factor production
                                                        is-anegative regulation of tumor necrosis factor production [GO:0032720] (35 genes, 40 annotations)
                                                                is-anegative regulation of tumor necrosis factor biosynthetic process
                                                        is-apositive regulation of tumor necrosis factor production +
                                                        is-aregulation of tumor necrosis factor biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-multicellular organism process
                                is-acytokine production
                                        negatively-regulatesnegative regulation of cytokine production
                                                is-anegative regulation of tumor necrosis factor superfamily cytokine production
                                                        is-anegative regulation of lymphotoxin A production +
                                                        is-anegative regulation of TRAIL production +
                                                        is-anegative regulation of tumor necrosis factor (ligand) superfamily member 11 production
                                                        is-anegative regulation of tumor necrosis factor production [GO:0032720] (35 genes, 40 annotations)
                                                                is-anegative regulation of tumor necrosis factor biosynthetic process


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-multicellular organism process
                                is-acytokine production
                                        regulatesregulation of cytokine production
                                                is-anegative regulation of cytokine production
                                                        is-anegative regulation of tumor necrosis factor superfamily cytokine production
                                                                is-anegative regulation of lymphotoxin A production +
                                                                is-anegative regulation of TRAIL production +
                                                                is-anegative regulation of tumor necrosis factor (ligand) superfamily member 11 production
                                                                is-anegative regulation of tumor necrosis factor production [GO:0032720] (35 genes, 40 annotations)
                                                                        is-anegative regulation of tumor necrosis factor biosynthetic process


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-multicellular organism process
                                is-acytokine production
                                        regulatesregulation of cytokine production
                                                is-aregulation of tumor necrosis factor superfamily cytokine production
                                                        is-anegative regulation of tumor necrosis factor superfamily cytokine production
                                                                is-anegative regulation of lymphotoxin A production +
                                                                is-anegative regulation of TRAIL production +
                                                                is-anegative regulation of tumor necrosis factor (ligand) superfamily member 11 production
                                                                is-anegative regulation of tumor necrosis factor production [GO:0032720] (35 genes, 40 annotations)
                                                                        is-anegative regulation of tumor necrosis factor biosynthetic process


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-multicellular organism process
                                is-acytokine production
                                        regulatesregulation of cytokine production
                                                is-aregulation of tumor necrosis factor superfamily cytokine production
                                                        is-aregulation of tumor necrosis factor production
                                                                is-anegative regulation of tumor necrosis factor production [GO:0032720] (35 genes, 40 annotations)
                                                                        is-anegative regulation of tumor necrosis factor biosynthetic process
                                                                is-apositive regulation of tumor necrosis factor production +
                                                                is-aregulation of tumor necrosis factor biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-multicellular organism process
                                is-acytokine production
                                        is-atumor necrosis factor superfamily cytokine production
                                                negatively-regulatesnegative regulation of tumor necrosis factor superfamily cytokine production
                                                        is-anegative regulation of lymphotoxin A production +
                                                        is-anegative regulation of TRAIL production +
                                                        is-anegative regulation of tumor necrosis factor (ligand) superfamily member 11 production
                                                        is-anegative regulation of tumor necrosis factor production [GO:0032720] (35 genes, 40 annotations)
                                                                is-anegative regulation of tumor necrosis factor biosynthetic process


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-multicellular organism process
                                is-acytokine production
                                        is-atumor necrosis factor superfamily cytokine production
                                                regulatesregulation of tumor necrosis factor superfamily cytokine production
                                                        is-anegative regulation of tumor necrosis factor superfamily cytokine production
                                                                is-anegative regulation of lymphotoxin A production +
                                                                is-anegative regulation of TRAIL production +
                                                                is-anegative regulation of tumor necrosis factor (ligand) superfamily member 11 production
                                                                is-anegative regulation of tumor necrosis factor production [GO:0032720] (35 genes, 40 annotations)
                                                                        is-anegative regulation of tumor necrosis factor biosynthetic process


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-multicellular organism process
                                is-acytokine production
                                        is-atumor necrosis factor superfamily cytokine production
                                                regulatesregulation of tumor necrosis factor superfamily cytokine production
                                                        is-aregulation of tumor necrosis factor production
                                                                is-anegative regulation of tumor necrosis factor production [GO:0032720] (35 genes, 40 annotations)
                                                                        is-anegative regulation of tumor necrosis factor biosynthetic process
                                                                is-apositive regulation of tumor necrosis factor production +
                                                                is-aregulation of tumor necrosis factor biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-multicellular organism process
                                is-acytokine production
                                        is-atumor necrosis factor superfamily cytokine production
                                                is-atumor necrosis factor production
                                                        negatively-regulatesnegative regulation of tumor necrosis factor production [GO:0032720] (35 genes, 40 annotations)
                                                                is-anegative regulation of tumor necrosis factor biosynthetic process
                                                        positively-regulatespositive regulation of tumor necrosis factor production +
                                                        regulatesregulation of tumor necrosis factor production +
                                                        part-oftumor necrosis factor biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-multicellular organism process
                                is-acytokine production
                                        is-atumor necrosis factor superfamily cytokine production
                                                is-atumor necrosis factor production
                                                        regulatesregulation of tumor necrosis factor production
                                                                is-anegative regulation of tumor necrosis factor production [GO:0032720] (35 genes, 40 annotations)
                                                                        is-anegative regulation of tumor necrosis factor biosynthetic process
                                                                is-apositive regulation of tumor necrosis factor production +
                                                                is-aregulation of tumor necrosis factor biosynthetic process +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-multicellular organism process
                                negatively-regulatesnegative regulation of multicellular organismal process
                                        is-anegative regulation of cytokine production
                                                is-anegative regulation of tumor necrosis factor superfamily cytokine production
                                                        is-anegative regulation of lymphotoxin A production +
                                                        is-anegative regulation of TRAIL production +
                                                        is-anegative regulation of tumor necrosis factor (ligand) superfamily member 11 production
                                                        is-anegative regulation of tumor necrosis factor production [GO:0032720] (35 genes, 40 annotations)
                                                                is-anegative regulation of tumor necrosis factor biosynthetic process


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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory