| GO term: | JNK cascade |
| Synonym: | c-Jun N-terminal kinase cascade |
| Synonym: | JNK1 cascade |
| Synonym: | JNK2 cascade |
| Synonym: | JNK3 cascade |
| Synonym: | MAPK10 cascade |
| Synonym: | MAPK8 cascade |
| Synonym: | MAPK9 cascade |
| Synonym: | SAPK cascade |
| Synonym: | stress-activated protein kinase cascade |
| GO id: | GO:0007254 |
| Definition: | An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell. |
| Number of paths to term: | 24 |
denotes an 'is-a' relationship
denotes a 'part-of' relationship
denotes a 'regulates' relationship
denotes a 'positively-regulates' relationship
denotes a 'negatively-regulates' relationship
biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionintracellular signal transductionintracellular protein kinase cascadeMAPK cascadestress-activated MAPK cascadeJNK cascade [GO:0007254] (148 genes, 234 annotations)activation of JNKK activityactivation of JNKKK activityactivation of JUN kinase activityJUN phosphorylationnegative regulation of JNK cascadepositive regulation of JNK cascaderegulation of JNK cascade +negative regulation of stress-activated MAPK cascade +p38MAPK cascade +positive regulation of stress-activated MAPK cascade +regulation of stress-activated MAPK cascade +biological_processbiological regulationregulation of biological processregulation of cellular processsignal transductionintracellular signal transductionintracellular protein kinase cascadestress-activated protein kinase signaling cascadestress-activated MAPK cascadeJNK cascade [GO:0007254] (148 genes, 234 annotations)activation of JNKK activityactivation of JNKKK activityactivation of JUN kinase activityJUN phosphorylationnegative regulation of JNK cascadepositive regulation of JNK cascaderegulation of JNK cascade +negative regulation of stress-activated MAPK cascade +p38MAPK cascade +positive regulation of stress-activated MAPK cascade +regulation of stress-activated MAPK cascade +biological_processcellular processregulation of cellular processsignal transductionintracellular signal transductionintracellular protein kinase cascadeMAPK cascadestress-activated MAPK cascadeJNK cascade [GO:0007254] (148 genes, 234 annotations)activation of JNKK activityactivation of JNKKK activityactivation of JUN kinase activityJUN phosphorylationnegative regulation of JNK cascadepositive regulation of JNK cascaderegulation of JNK cascade +negative regulation of stress-activated MAPK cascade +p38MAPK cascade +positive regulation of stress-activated MAPK cascade +regulation of stress-activated MAPK cascade +biological_processcellular processregulation of cellular processsignal transductionintracellular signal transductionintracellular protein kinase cascadestress-activated protein kinase signaling cascadestress-activated MAPK cascadeJNK cascade [GO:0007254] (148 genes, 234 annotations)activation of JNKK activityactivation of JNKKK activityactivation of JUN kinase activityJUN phosphorylationnegative regulation of JNK cascadepositive regulation of JNK cascaderegulation of JNK cascade +negative regulation of stress-activated MAPK cascade +p38MAPK cascade +positive regulation of stress-activated MAPK cascade +regulation of stress-activated MAPK cascade +biological_processcellular processsingle-organism cellular processcell communicationsignal transductionintracellular signal transductionintracellular protein kinase cascadeMAPK cascadestress-activated MAPK cascadeJNK cascade [GO:0007254] (148 genes, 234 annotations)activation of JNKK activityactivation of JNKKK activityactivation of JUN kinase activityJUN phosphorylationnegative regulation of JNK cascadepositive regulation of JNK cascaderegulation of JNK cascade +negative regulation of stress-activated MAPK cascade +p38MAPK cascade +positive regulation of stress-activated MAPK cascade +regulation of stress-activated MAPK cascade +biological_processcellular processsingle-organism cellular processcell communicationsignal transductionintracellular signal transductionintracellular protein kinase cascadestress-activated protein kinase signaling cascadestress-activated MAPK cascadeJNK cascade [GO:0007254] (148 genes, 234 annotations)activation of JNKK activityactivation of JNKKK activityactivation of JUN kinase activityJUN phosphorylationnegative regulation of JNK cascadepositive regulation of JNK cascaderegulation of JNK cascade +negative regulation of stress-activated MAPK cascade +p38MAPK cascade +positive regulation of stress-activated MAPK cascade +regulation of stress-activated MAPK cascade +biological_processcellular processsingle-organism cellular processcellular response to stimuluscellular response to stressstress-activated protein kinase signaling cascadestress-activated MAPK cascadeJNK cascade [GO:0007254] (148 genes, 234 annotations)activation of JNKK activityactivation of JNKKK activityactivation of JUN kinase activityJUN phosphorylationnegative regulation of JNK cascadepositive regulation of JNK cascaderegulation of JNK cascade +negative regulation of stress-activated MAPK cascade +p38MAPK cascade +positive regulation of stress-activated MAPK cascade +regulation of stress-activated MAPK cascade +biological_processcellular processsingle-organism cellular processcellular response to stimulussignal transductionintracellular signal transductionintracellular protein kinase cascadeMAPK cascadestress-activated MAPK cascadeJNK cascade [GO:0007254] (148 genes, 234 annotations)activation of JNKK activityactivation of JNKKK activityactivation of JUN kinase activityJUN phosphorylationnegative regulation of JNK cascadepositive regulation of JNK cascaderegulation of JNK cascade +negative regulation of stress-activated MAPK cascade +p38MAPK cascade +positive regulation of stress-activated MAPK cascade +regulation of stress-activated MAPK cascade +biological_processcellular processsingle-organism cellular processcellular response to stimulussignal transductionintracellular signal transductionintracellular protein kinase cascadestress-activated protein kinase signaling cascadestress-activated MAPK cascadeJNK cascade [GO:0007254] (148 genes, 234 annotations)activation of JNKK activityactivation of JNKKK activityactivation of JUN kinase activityJUN phosphorylationnegative regulation of JNK cascadepositive regulation of JNK cascaderegulation of JNK cascade +negative regulation of stress-activated MAPK cascade +p38MAPK cascade +positive regulation of stress-activated MAPK cascade +regulation of stress-activated MAPK cascade +biological_processregulation of biological processregulation of cellular processsignal transductionintracellular signal transductionintracellular protein kinase cascadeMAPK cascadestress-activated MAPK cascadeJNK cascade [GO:0007254] (148 genes, 234 annotations)activation of JNKK activityactivation of JNKKK activityactivation of JUN kinase activityJUN phosphorylationnegative regulation of JNK cascadepositive regulation of JNK cascaderegulation of JNK cascade +negative regulation of stress-activated MAPK cascade +p38MAPK cascade +positive regulation of stress-activated MAPK cascade +regulation of stress-activated MAPK cascade +biological_processregulation of biological processregulation of cellular processsignal transductionintracellular signal transductionintracellular protein kinase cascadestress-activated protein kinase signaling cascadestress-activated MAPK cascadeJNK cascade [GO:0007254] (148 genes, 234 annotations)activation of JNKK activityactivation of JNKKK activityactivation of JUN kinase activityJUN phosphorylationnegative regulation of JNK cascadepositive regulation of JNK cascaderegulation of JNK cascade +negative regulation of stress-activated MAPK cascade +p38MAPK cascade +positive regulation of stress-activated MAPK cascade +regulation of stress-activated MAPK cascade +biological_processresponse to stimuluscellular response to stimuluscellular response to stressstress-activated protein kinase signaling cascadestress-activated MAPK cascadeJNK cascade [GO:0007254] (148 genes, 234 annotations)activation of JNKK activityactivation of JNKKK activityactivation of JUN kinase activityJUN phosphorylationnegative regulation of JNK cascadepositive regulation of JNK cascaderegulation of JNK cascade +negative regulation of stress-activated MAPK cascade +p38MAPK cascade +positive regulation of stress-activated MAPK cascade +regulation of stress-activated MAPK cascade +biological_processresponse to stimuluscellular response to stimulussignal transductionintracellular signal transductionintracellular protein kinase cascadeMAPK cascadestress-activated MAPK cascadeJNK cascade [GO:0007254] (148 genes, 234 annotations)activation of JNKK activityactivation of JNKKK activityactivation of JUN kinase activityJUN phosphorylationnegative regulation of JNK cascadepositive regulation of JNK cascaderegulation of JNK cascade +negative regulation of stress-activated MAPK cascade +p38MAPK cascade +positive regulation of stress-activated MAPK cascade +regulation of stress-activated MAPK cascade +biological_processresponse to stimuluscellular response to stimulussignal transductionintracellular signal transductionintracellular protein kinase cascadestress-activated protein kinase signaling cascadestress-activated MAPK cascadeJNK cascade [GO:0007254] (148 genes, 234 annotations)activation of JNKK activityactivation of JNKKK activityactivation of JUN kinase activityJUN phosphorylationnegative regulation of JNK cascadepositive regulation of JNK cascaderegulation of JNK cascade +negative regulation of stress-activated MAPK cascade +p38MAPK cascade +positive regulation of stress-activated MAPK cascade +regulation of stress-activated MAPK cascade +biological_processresponse to stimulusresponse to stresscellular response to stressstress-activated protein kinase signaling cascadestress-activated MAPK cascadeJNK cascade [GO:0007254] (148 genes, 234 annotations)activation of JNKK activityactivation of JNKKK activityactivation of JUN kinase activityJUN phosphorylationnegative regulation of JNK cascadepositive regulation of JNK cascaderegulation of JNK cascade +negative regulation of stress-activated MAPK cascade +p38MAPK cascade +positive regulation of stress-activated MAPK cascade +regulation of stress-activated MAPK cascade +biological_processsignalingsingle organism signalingsignal transductionintracellular signal transductionintracellular protein kinase cascadeMAPK cascadestress-activated MAPK cascadeJNK cascade [GO:0007254] (148 genes, 234 annotations)activation of JNKK activityactivation of JNKKK activityactivation of JUN kinase activityJUN phosphorylationnegative regulation of JNK cascadepositive regulation of JNK cascaderegulation of JNK cascade +negative regulation of stress-activated MAPK cascade +p38MAPK cascade +positive regulation of stress-activated MAPK cascade +regulation of stress-activated MAPK cascade +biological_processsignalingsingle organism signalingsignal transductionintracellular signal transductionintracellular protein kinase cascadestress-activated protein kinase signaling cascadestress-activated MAPK cascadeJNK cascade [GO:0007254] (148 genes, 234 annotations)activation of JNKK activityactivation of JNKKK activityactivation of JUN kinase activityJUN phosphorylationnegative regulation of JNK cascadepositive regulation of JNK cascaderegulation of JNK cascade +negative regulation of stress-activated MAPK cascade +p38MAPK cascade +positive regulation of stress-activated MAPK cascade +regulation of stress-activated MAPK cascade +biological_processsingle-organism processsingle organism signalingsignal transductionintracellular signal transductionintracellular protein kinase cascadeMAPK cascadestress-activated MAPK cascadeJNK cascade [GO:0007254] (148 genes, 234 annotations)activation of JNKK activityactivation of JNKKK activityactivation of JUN kinase activityJUN phosphorylationnegative regulation of JNK cascadepositive regulation of JNK cascaderegulation of JNK cascade +negative regulation of stress-activated MAPK cascade +p38MAPK cascade +positive regulation of stress-activated MAPK cascade +regulation of stress-activated MAPK cascade +biological_processsingle-organism processsingle organism signalingsignal transductionintracellular signal transductionintracellular protein kinase cascadestress-activated protein kinase signaling cascadestress-activated MAPK cascadeJNK cascade [GO:0007254] (148 genes, 234 annotations)activation of JNKK activityactivation of JNKKK activityactivation of JUN kinase activityJUN phosphorylationnegative regulation of JNK cascadepositive regulation of JNK cascaderegulation of JNK cascade +negative regulation of stress-activated MAPK cascade +p38MAPK cascade +positive regulation of stress-activated MAPK cascade +regulation of stress-activated MAPK cascade +biological_processsingle-organism processsingle-organism cellular processcell communicationsignal transductionintracellular signal transductionintracellular protein kinase cascadeMAPK cascadestress-activated MAPK cascadeJNK cascade [GO:0007254] (148 genes, 234 annotations)activation of JNKK activityactivation of JNKKK activityactivation of JUN kinase activityJUN phosphorylationnegative regulation of JNK cascadepositive regulation of JNK cascaderegulation of JNK cascade +negative regulation of stress-activated MAPK cascade +p38MAPK cascade +positive regulation of stress-activated MAPK cascade +regulation of stress-activated MAPK cascade +biological_processsingle-organism processsingle-organism cellular processcell communicationsignal transductionintracellular signal transductionintracellular protein kinase cascadestress-activated protein kinase signaling cascadestress-activated MAPK cascadeJNK cascade [GO:0007254] (148 genes, 234 annotations)activation of JNKK activityactivation of JNKKK activityactivation of JUN kinase activityJUN phosphorylationnegative regulation of JNK cascadepositive regulation of JNK cascaderegulation of JNK cascade +negative regulation of stress-activated MAPK cascade +p38MAPK cascade +positive regulation of stress-activated MAPK cascade +regulation of stress-activated MAPK cascade +biological_processsingle-organism processsingle-organism cellular processcellular response to stimuluscellular response to stressstress-activated protein kinase signaling cascadestress-activated MAPK cascadeJNK cascade [GO:0007254] (148 genes, 234 annotations)activation of JNKK activityactivation of JNKKK activityactivation of JUN kinase activityJUN phosphorylationnegative regulation of JNK cascadepositive regulation of JNK cascaderegulation of JNK cascade +negative regulation of stress-activated MAPK cascade +p38MAPK cascade +positive regulation of stress-activated MAPK cascade +regulation of stress-activated MAPK cascade +biological_processsingle-organism processsingle-organism cellular processcellular response to stimulussignal transductionintracellular signal transductionintracellular protein kinase cascadeMAPK cascadestress-activated MAPK cascadeJNK cascade [GO:0007254] (148 genes, 234 annotations)activation of JNKK activityactivation of JNKKK activityactivation of JUN kinase activityJUN phosphorylationnegative regulation of JNK cascadepositive regulation of JNK cascaderegulation of JNK cascade +negative regulation of stress-activated MAPK cascade +p38MAPK cascade +positive regulation of stress-activated MAPK cascade +regulation of stress-activated MAPK cascade +biological_processsingle-organism processsingle-organism cellular processcellular response to stimulussignal transductionintracellular signal transductionintracellular protein kinase cascadestress-activated protein kinase signaling cascadestress-activated MAPK cascadeJNK cascade [GO:0007254] (148 genes, 234 annotations)activation of JNKK activityactivation of JNKKK activityactivation of JUN kinase activityJUN phosphorylationnegative regulation of JNK cascadepositive regulation of JNK cascaderegulation of JNK cascade +negative regulation of stress-activated MAPK cascade +p38MAPK cascade +positive regulation of stress-activated MAPK cascade +regulation of stress-activated MAPK cascade +Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc |
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last database update 05/08/2013 MGI 5.13 |
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