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Term Detail
GO term:JNK cascade
Synonym: c-Jun N-terminal kinase cascade
Synonym: JNK1 cascade
Synonym: JNK2 cascade
Synonym: JNK3 cascade
Synonym: MAPK10 cascade
Synonym: MAPK8 cascade
Synonym: MAPK9 cascade
Synonym: SAPK cascade
Synonym: stress-activated protein kinase cascade
GO id:GO:0007254
Definition:An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
Number of paths to term: 36

is-adenotes an 'is-a' relationship
part-ofdenotes a 'part-of' relationship
regulatesdenotes a 'regulates' relationship
positively-regulatesdenotes a 'positively-regulates' relationship
negatively-regulatesdenotes a 'negatively-regulates' relationship


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-aintracellular signal transduction
                                                        is-aMAPK cascade
                                                                is-astress-activated MAPK cascade
                                                                        is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                                part-ofactivation of JNKK activity
                                                                                part-ofactivation of JNKKK activity
                                                                                part-ofactivation of JUN kinase activity
                                                                                part-ofJUN phosphorylation
                                                                                negatively-regulatesnegative regulation of JNK cascade +
                                                                                positively-regulatespositive regulation of JNK cascade +
                                                                                regulatesregulation of JNK cascade +
                                                                        is-aMAPK cascade in response to starvation
                                                                        negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                                        is-ap38MAPK cascade +
                                                                        positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                                        regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-aintracellular signal transduction
                                                        is-astress-activated protein kinase signaling cascade
                                                                is-astress-activated MAPK cascade
                                                                        is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                                part-ofactivation of JNKK activity
                                                                                part-ofactivation of JNKKK activity
                                                                                part-ofactivation of JUN kinase activity
                                                                                part-ofJUN phosphorylation
                                                                                negatively-regulatesnegative regulation of JNK cascade +
                                                                                positively-regulatespositive regulation of JNK cascade +
                                                                                regulatesregulation of JNK cascade +
                                                                        is-aMAPK cascade in response to starvation
                                                                        negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                                        is-ap38MAPK cascade +
                                                                        positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                                        regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-abiological regulation
                        is-aregulation of biological process
                                is-aregulation of cellular process
                                        is-asignal transduction
                                                is-asignal transduction by phosphorylation
                                                        is-aMAPK cascade
                                                                is-astress-activated MAPK cascade
                                                                        is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                                part-ofactivation of JNKK activity
                                                                                part-ofactivation of JNKKK activity
                                                                                part-ofactivation of JUN kinase activity
                                                                                part-ofJUN phosphorylation
                                                                                negatively-regulatesnegative regulation of JNK cascade +
                                                                                positively-regulatespositive regulation of JNK cascade +
                                                                                regulatesregulation of JNK cascade +
                                                                        is-aMAPK cascade in response to starvation
                                                                        negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                                        is-ap38MAPK cascade +
                                                                        positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                                        regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular metabolic process
                                is-aphosphorus metabolic process
                                        is-aphosphate-containing compound metabolic process
                                                is-aphosphorylation
                                                        is-asignal transduction by phosphorylation
                                                                is-aMAPK cascade
                                                                        is-astress-activated MAPK cascade
                                                                                is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                                        part-ofactivation of JNKK activity
                                                                                        part-ofactivation of JNKKK activity
                                                                                        part-ofactivation of JUN kinase activity
                                                                                        part-ofJUN phosphorylation
                                                                                        negatively-regulatesnegative regulation of JNK cascade +
                                                                                        positively-regulatespositive regulation of JNK cascade +
                                                                                        regulatesregulation of JNK cascade +
                                                                                is-aMAPK cascade in response to starvation
                                                                                negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                                                is-ap38MAPK cascade +
                                                                                positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                                                regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-acellular response to stress
                                        is-astress-activated protein kinase signaling cascade
                                                is-astress-activated MAPK cascade
                                                        is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                part-ofactivation of JNKK activity
                                                                part-ofactivation of JNKKK activity
                                                                part-ofactivation of JUN kinase activity
                                                                part-ofJUN phosphorylation
                                                                negatively-regulatesnegative regulation of JNK cascade +
                                                                positively-regulatespositive regulation of JNK cascade +
                                                                regulatesregulation of JNK cascade +
                                                        is-aMAPK cascade in response to starvation
                                                        negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                        is-ap38MAPK cascade +
                                                        positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                        regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-aMAPK cascade
                                                        is-astress-activated MAPK cascade
                                                                is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                        part-ofactivation of JNKK activity
                                                                        part-ofactivation of JNKKK activity
                                                                        part-ofactivation of JUN kinase activity
                                                                        part-ofJUN phosphorylation
                                                                        negatively-regulatesnegative regulation of JNK cascade +
                                                                        positively-regulatespositive regulation of JNK cascade +
                                                                        regulatesregulation of JNK cascade +
                                                                is-aMAPK cascade in response to starvation
                                                                negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                                is-ap38MAPK cascade +
                                                                positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                                regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-astress-activated protein kinase signaling cascade
                                                        is-astress-activated MAPK cascade
                                                                is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                        part-ofactivation of JNKK activity
                                                                        part-ofactivation of JNKKK activity
                                                                        part-ofactivation of JUN kinase activity
                                                                        part-ofJUN phosphorylation
                                                                        negatively-regulatesnegative regulation of JNK cascade +
                                                                        positively-regulatespositive regulation of JNK cascade +
                                                                        regulatesregulation of JNK cascade +
                                                                is-aMAPK cascade in response to starvation
                                                                negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                                is-ap38MAPK cascade +
                                                                positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                                regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-asignal transduction by phosphorylation
                                                is-aMAPK cascade
                                                        is-astress-activated MAPK cascade
                                                                is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                        part-ofactivation of JNKK activity
                                                                        part-ofactivation of JNKKK activity
                                                                        part-ofactivation of JUN kinase activity
                                                                        part-ofJUN phosphorylation
                                                                        negatively-regulatesnegative regulation of JNK cascade +
                                                                        positively-regulatespositive regulation of JNK cascade +
                                                                        regulatesregulation of JNK cascade +
                                                                is-aMAPK cascade in response to starvation
                                                                negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                                is-ap38MAPK cascade +
                                                                positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                                regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-aMAPK cascade
                                                        is-astress-activated MAPK cascade
                                                                is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                        part-ofactivation of JNKK activity
                                                                        part-ofactivation of JNKKK activity
                                                                        part-ofactivation of JUN kinase activity
                                                                        part-ofJUN phosphorylation
                                                                        negatively-regulatesnegative regulation of JNK cascade +
                                                                        positively-regulatespositive regulation of JNK cascade +
                                                                        regulatesregulation of JNK cascade +
                                                                is-aMAPK cascade in response to starvation
                                                                negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                                is-ap38MAPK cascade +
                                                                positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                                regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-astress-activated protein kinase signaling cascade
                                                        is-astress-activated MAPK cascade
                                                                is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                        part-ofactivation of JNKK activity
                                                                        part-ofactivation of JNKKK activity
                                                                        part-ofactivation of JUN kinase activity
                                                                        part-ofJUN phosphorylation
                                                                        negatively-regulatesnegative regulation of JNK cascade +
                                                                        positively-regulatespositive regulation of JNK cascade +
                                                                        regulatesregulation of JNK cascade +
                                                                is-aMAPK cascade in response to starvation
                                                                negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                                is-ap38MAPK cascade +
                                                                positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                                regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        regulatesregulation of cellular process
                                is-asignal transduction
                                        is-asignal transduction by phosphorylation
                                                is-aMAPK cascade
                                                        is-astress-activated MAPK cascade
                                                                is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                        part-ofactivation of JNKK activity
                                                                        part-ofactivation of JNKKK activity
                                                                        part-ofactivation of JUN kinase activity
                                                                        part-ofJUN phosphorylation
                                                                        negatively-regulatesnegative regulation of JNK cascade +
                                                                        positively-regulatespositive regulation of JNK cascade +
                                                                        regulatesregulation of JNK cascade +
                                                                is-aMAPK cascade in response to starvation
                                                                negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                                is-ap38MAPK cascade +
                                                                positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                                regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aintracellular signal transduction
                                                        is-aMAPK cascade
                                                                is-astress-activated MAPK cascade
                                                                        is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                                part-ofactivation of JNKK activity
                                                                                part-ofactivation of JNKKK activity
                                                                                part-ofactivation of JUN kinase activity
                                                                                part-ofJUN phosphorylation
                                                                                negatively-regulatesnegative regulation of JNK cascade +
                                                                                positively-regulatespositive regulation of JNK cascade +
                                                                                regulatesregulation of JNK cascade +
                                                                        is-aMAPK cascade in response to starvation
                                                                        negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                                        is-ap38MAPK cascade +
                                                                        positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                                        regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aintracellular signal transduction
                                                        is-astress-activated protein kinase signaling cascade
                                                                is-astress-activated MAPK cascade
                                                                        is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                                part-ofactivation of JNKK activity
                                                                                part-ofactivation of JNKKK activity
                                                                                part-ofactivation of JUN kinase activity
                                                                                part-ofJUN phosphorylation
                                                                                negatively-regulatesnegative regulation of JNK cascade +
                                                                                positively-regulatespositive regulation of JNK cascade +
                                                                                regulatesregulation of JNK cascade +
                                                                        is-aMAPK cascade in response to starvation
                                                                        negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                                        is-ap38MAPK cascade +
                                                                        positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                                        regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-asignal transduction by phosphorylation
                                                        is-aMAPK cascade
                                                                is-astress-activated MAPK cascade
                                                                        is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                                part-ofactivation of JNKK activity
                                                                                part-ofactivation of JNKKK activity
                                                                                part-ofactivation of JUN kinase activity
                                                                                part-ofJUN phosphorylation
                                                                                negatively-regulatesnegative regulation of JNK cascade +
                                                                                positively-regulatespositive regulation of JNK cascade +
                                                                                regulatesregulation of JNK cascade +
                                                                        is-aMAPK cascade in response to starvation
                                                                        negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                                        is-ap38MAPK cascade +
                                                                        positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                                        regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-acellular process
                        is-asingle-organism cellular process
                                is-asignal transduction by phosphorylation
                                        is-aMAPK cascade
                                                is-astress-activated MAPK cascade
                                                        is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                part-ofactivation of JNKK activity
                                                                part-ofactivation of JNKKK activity
                                                                part-ofactivation of JUN kinase activity
                                                                part-ofJUN phosphorylation
                                                                negatively-regulatesnegative regulation of JNK cascade +
                                                                positively-regulatespositive regulation of JNK cascade +
                                                                regulatesregulation of JNK cascade +
                                                        is-aMAPK cascade in response to starvation
                                                        negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                        is-ap38MAPK cascade +
                                                        positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                        regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-acellular metabolic process
                                is-aphosphorus metabolic process
                                        is-aphosphate-containing compound metabolic process
                                                is-aphosphorylation
                                                        is-asignal transduction by phosphorylation
                                                                is-aMAPK cascade
                                                                        is-astress-activated MAPK cascade
                                                                                is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                                        part-ofactivation of JNKK activity
                                                                                        part-ofactivation of JNKKK activity
                                                                                        part-ofactivation of JUN kinase activity
                                                                                        part-ofJUN phosphorylation
                                                                                        negatively-regulatesnegative regulation of JNK cascade +
                                                                                        positively-regulatespositive regulation of JNK cascade +
                                                                                        regulatesregulation of JNK cascade +
                                                                                is-aMAPK cascade in response to starvation
                                                                                negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                                                is-ap38MAPK cascade +
                                                                                positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                                                regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-ametabolic process
                        is-asingle-organism metabolic process
                                is-asignal transduction by phosphorylation
                                        is-aMAPK cascade
                                                is-astress-activated MAPK cascade
                                                        is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                part-ofactivation of JNKK activity
                                                                part-ofactivation of JNKKK activity
                                                                part-ofactivation of JUN kinase activity
                                                                part-ofJUN phosphorylation
                                                                negatively-regulatesnegative regulation of JNK cascade +
                                                                positively-regulatespositive regulation of JNK cascade +
                                                                regulatesregulation of JNK cascade +
                                                        is-aMAPK cascade in response to starvation
                                                        negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                        is-ap38MAPK cascade +
                                                        positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                        regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-aMAPK cascade
                                                        is-astress-activated MAPK cascade
                                                                is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                        part-ofactivation of JNKK activity
                                                                        part-ofactivation of JNKKK activity
                                                                        part-ofactivation of JUN kinase activity
                                                                        part-ofJUN phosphorylation
                                                                        negatively-regulatesnegative regulation of JNK cascade +
                                                                        positively-regulatespositive regulation of JNK cascade +
                                                                        regulatesregulation of JNK cascade +
                                                                is-aMAPK cascade in response to starvation
                                                                negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                                is-ap38MAPK cascade +
                                                                positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                                regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-astress-activated protein kinase signaling cascade
                                                        is-astress-activated MAPK cascade
                                                                is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                        part-ofactivation of JNKK activity
                                                                        part-ofactivation of JNKKK activity
                                                                        part-ofactivation of JUN kinase activity
                                                                        part-ofJUN phosphorylation
                                                                        negatively-regulatesnegative regulation of JNK cascade +
                                                                        positively-regulatespositive regulation of JNK cascade +
                                                                        regulatesregulation of JNK cascade +
                                                                is-aMAPK cascade in response to starvation
                                                                negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                                is-ap38MAPK cascade +
                                                                positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                                regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                regulatesregulation of biological process
                        is-aregulation of cellular process
                                is-asignal transduction
                                        is-asignal transduction by phosphorylation
                                                is-aMAPK cascade
                                                        is-astress-activated MAPK cascade
                                                                is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                        part-ofactivation of JNKK activity
                                                                        part-ofactivation of JNKKK activity
                                                                        part-ofactivation of JUN kinase activity
                                                                        part-ofJUN phosphorylation
                                                                        negatively-regulatesnegative regulation of JNK cascade +
                                                                        positively-regulatespositive regulation of JNK cascade +
                                                                        regulatesregulation of JNK cascade +
                                                                is-aMAPK cascade in response to starvation
                                                                negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                                is-ap38MAPK cascade +
                                                                positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                                regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-acellular response to stress
                                        is-astress-activated protein kinase signaling cascade
                                                is-astress-activated MAPK cascade
                                                        is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                part-ofactivation of JNKK activity
                                                                part-ofactivation of JNKKK activity
                                                                part-ofactivation of JUN kinase activity
                                                                part-ofJUN phosphorylation
                                                                negatively-regulatesnegative regulation of JNK cascade +
                                                                positively-regulatespositive regulation of JNK cascade +
                                                                regulatesregulation of JNK cascade +
                                                        is-aMAPK cascade in response to starvation
                                                        negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                        is-ap38MAPK cascade +
                                                        positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                        regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-aMAPK cascade
                                                        is-astress-activated MAPK cascade
                                                                is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                        part-ofactivation of JNKK activity
                                                                        part-ofactivation of JNKKK activity
                                                                        part-ofactivation of JUN kinase activity
                                                                        part-ofJUN phosphorylation
                                                                        negatively-regulatesnegative regulation of JNK cascade +
                                                                        positively-regulatespositive regulation of JNK cascade +
                                                                        regulatesregulation of JNK cascade +
                                                                is-aMAPK cascade in response to starvation
                                                                negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                                is-ap38MAPK cascade +
                                                                positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                                regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-aintracellular signal transduction
                                                is-astress-activated protein kinase signaling cascade
                                                        is-astress-activated MAPK cascade
                                                                is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                        part-ofactivation of JNKK activity
                                                                        part-ofactivation of JNKKK activity
                                                                        part-ofactivation of JUN kinase activity
                                                                        part-ofJUN phosphorylation
                                                                        negatively-regulatesnegative regulation of JNK cascade +
                                                                        positively-regulatespositive regulation of JNK cascade +
                                                                        regulatesregulation of JNK cascade +
                                                                is-aMAPK cascade in response to starvation
                                                                negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                                is-ap38MAPK cascade +
                                                                positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                                regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-acellular response to stimulus
                                is-asignal transduction
                                        is-asignal transduction by phosphorylation
                                                is-aMAPK cascade
                                                        is-astress-activated MAPK cascade
                                                                is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                        part-ofactivation of JNKK activity
                                                                        part-ofactivation of JNKKK activity
                                                                        part-ofactivation of JUN kinase activity
                                                                        part-ofJUN phosphorylation
                                                                        negatively-regulatesnegative regulation of JNK cascade +
                                                                        positively-regulatespositive regulation of JNK cascade +
                                                                        regulatesregulation of JNK cascade +
                                                                is-aMAPK cascade in response to starvation
                                                                negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                                is-ap38MAPK cascade +
                                                                positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                                regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-aresponse to stimulus
                        is-aresponse to stress
                                is-acellular response to stress
                                        is-astress-activated protein kinase signaling cascade
                                                is-astress-activated MAPK cascade
                                                        is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                part-ofactivation of JNKK activity
                                                                part-ofactivation of JNKKK activity
                                                                part-ofactivation of JUN kinase activity
                                                                part-ofJUN phosphorylation
                                                                negatively-regulatesnegative regulation of JNK cascade +
                                                                positively-regulatespositive regulation of JNK cascade +
                                                                regulatesregulation of JNK cascade +
                                                        is-aMAPK cascade in response to starvation
                                                        negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                        is-ap38MAPK cascade +
                                                        positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                        regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aintracellular signal transduction
                                                is-aMAPK cascade
                                                        is-astress-activated MAPK cascade
                                                                is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                        part-ofactivation of JNKK activity
                                                                        part-ofactivation of JNKKK activity
                                                                        part-ofactivation of JUN kinase activity
                                                                        part-ofJUN phosphorylation
                                                                        negatively-regulatesnegative regulation of JNK cascade +
                                                                        positively-regulatespositive regulation of JNK cascade +
                                                                        regulatesregulation of JNK cascade +
                                                                is-aMAPK cascade in response to starvation
                                                                negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                                is-ap38MAPK cascade +
                                                                positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                                regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aintracellular signal transduction
                                                is-astress-activated protein kinase signaling cascade
                                                        is-astress-activated MAPK cascade
                                                                is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                        part-ofactivation of JNKK activity
                                                                        part-ofactivation of JNKKK activity
                                                                        part-ofactivation of JUN kinase activity
                                                                        part-ofJUN phosphorylation
                                                                        negatively-regulatesnegative regulation of JNK cascade +
                                                                        positively-regulatespositive regulation of JNK cascade +
                                                                        regulatesregulation of JNK cascade +
                                                                is-aMAPK cascade in response to starvation
                                                                negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                                is-ap38MAPK cascade +
                                                                positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                                regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-asignaling
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-asignal transduction by phosphorylation
                                                is-aMAPK cascade
                                                        is-astress-activated MAPK cascade
                                                                is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                        part-ofactivation of JNKK activity
                                                                        part-ofactivation of JNKKK activity
                                                                        part-ofactivation of JUN kinase activity
                                                                        part-ofJUN phosphorylation
                                                                        negatively-regulatesnegative regulation of JNK cascade +
                                                                        positively-regulatespositive regulation of JNK cascade +
                                                                        regulatesregulation of JNK cascade +
                                                                is-aMAPK cascade in response to starvation
                                                                negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                                is-ap38MAPK cascade +
                                                                positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                                regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aintracellular signal transduction
                                                is-aMAPK cascade
                                                        is-astress-activated MAPK cascade
                                                                is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                        part-ofactivation of JNKK activity
                                                                        part-ofactivation of JNKKK activity
                                                                        part-ofactivation of JUN kinase activity
                                                                        part-ofJUN phosphorylation
                                                                        negatively-regulatesnegative regulation of JNK cascade +
                                                                        positively-regulatespositive regulation of JNK cascade +
                                                                        regulatesregulation of JNK cascade +
                                                                is-aMAPK cascade in response to starvation
                                                                negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                                is-ap38MAPK cascade +
                                                                positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                                regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-aintracellular signal transduction
                                                is-astress-activated protein kinase signaling cascade
                                                        is-astress-activated MAPK cascade
                                                                is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                        part-ofactivation of JNKK activity
                                                                        part-ofactivation of JNKKK activity
                                                                        part-ofactivation of JUN kinase activity
                                                                        part-ofJUN phosphorylation
                                                                        negatively-regulatesnegative regulation of JNK cascade +
                                                                        positively-regulatespositive regulation of JNK cascade +
                                                                        regulatesregulation of JNK cascade +
                                                                is-aMAPK cascade in response to starvation
                                                                negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                                is-ap38MAPK cascade +
                                                                positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                                regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle organism signaling
                                part-ofsignal transduction
                                        is-asignal transduction by phosphorylation
                                                is-aMAPK cascade
                                                        is-astress-activated MAPK cascade
                                                                is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                        part-ofactivation of JNKK activity
                                                                        part-ofactivation of JNKKK activity
                                                                        part-ofactivation of JUN kinase activity
                                                                        part-ofJUN phosphorylation
                                                                        negatively-regulatesnegative regulation of JNK cascade +
                                                                        positively-regulatespositive regulation of JNK cascade +
                                                                        regulatesregulation of JNK cascade +
                                                                is-aMAPK cascade in response to starvation
                                                                negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                                is-ap38MAPK cascade +
                                                                positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                                regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aintracellular signal transduction
                                                        is-aMAPK cascade
                                                                is-astress-activated MAPK cascade
                                                                        is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                                part-ofactivation of JNKK activity
                                                                                part-ofactivation of JNKKK activity
                                                                                part-ofactivation of JUN kinase activity
                                                                                part-ofJUN phosphorylation
                                                                                negatively-regulatesnegative regulation of JNK cascade +
                                                                                positively-regulatespositive regulation of JNK cascade +
                                                                                regulatesregulation of JNK cascade +
                                                                        is-aMAPK cascade in response to starvation
                                                                        negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                                        is-ap38MAPK cascade +
                                                                        positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                                        regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-aintracellular signal transduction
                                                        is-astress-activated protein kinase signaling cascade
                                                                is-astress-activated MAPK cascade
                                                                        is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                                part-ofactivation of JNKK activity
                                                                                part-ofactivation of JNKKK activity
                                                                                part-ofactivation of JUN kinase activity
                                                                                part-ofJUN phosphorylation
                                                                                negatively-regulatesnegative regulation of JNK cascade +
                                                                                positively-regulatespositive regulation of JNK cascade +
                                                                                regulatesregulation of JNK cascade +
                                                                        is-aMAPK cascade in response to starvation
                                                                        negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                                        is-ap38MAPK cascade +
                                                                        positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                                        regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-acell communication
                                        part-ofsignal transduction
                                                is-asignal transduction by phosphorylation
                                                        is-aMAPK cascade
                                                                is-astress-activated MAPK cascade
                                                                        is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                                part-ofactivation of JNKK activity
                                                                                part-ofactivation of JNKKK activity
                                                                                part-ofactivation of JUN kinase activity
                                                                                part-ofJUN phosphorylation
                                                                                negatively-regulatesnegative regulation of JNK cascade +
                                                                                positively-regulatespositive regulation of JNK cascade +
                                                                                regulatesregulation of JNK cascade +
                                                                        is-aMAPK cascade in response to starvation
                                                                        negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                                        is-ap38MAPK cascade +
                                                                        positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                                        regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism cellular process
                                is-asignal transduction by phosphorylation
                                        is-aMAPK cascade
                                                is-astress-activated MAPK cascade
                                                        is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                part-ofactivation of JNKK activity
                                                                part-ofactivation of JNKKK activity
                                                                part-ofactivation of JUN kinase activity
                                                                part-ofJUN phosphorylation
                                                                negatively-regulatesnegative regulation of JNK cascade +
                                                                positively-regulatespositive regulation of JNK cascade +
                                                                regulatesregulation of JNK cascade +
                                                        is-aMAPK cascade in response to starvation
                                                        negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                        is-ap38MAPK cascade +
                                                        positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                        regulatesregulation of stress-activated MAPK cascade +


Gene_Ontology
        is-abiological_process
                is-asingle-organism process
                        is-asingle-organism metabolic process
                                is-asignal transduction by phosphorylation
                                        is-aMAPK cascade
                                                is-astress-activated MAPK cascade
                                                        is-aJNK cascade [GO:0007254] (161 genes, 244 annotations)
                                                                part-ofactivation of JNKK activity
                                                                part-ofactivation of JNKKK activity
                                                                part-ofactivation of JUN kinase activity
                                                                part-ofJUN phosphorylation
                                                                negatively-regulatesnegative regulation of JNK cascade +
                                                                positively-regulatespositive regulation of JNK cascade +
                                                                regulatesregulation of JNK cascade +
                                                        is-aMAPK cascade in response to starvation
                                                        negatively-regulatesnegative regulation of stress-activated MAPK cascade +
                                                        is-ap38MAPK cascade +
                                                        positively-regulatespositive regulation of stress-activated MAPK cascade +
                                                        regulatesregulation of stress-activated MAPK cascade +


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory