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Nod2
Gene Detail
 Symbol
Name
ID
Nod2
nucleotide-binding oligomerization domain containing 2
MGI:2429397
Synonyms Card15, F830032C23Rik, Nlrc2
Feature Type protein coding gene
Genetic Map
Chromosome 8
43.51 cM, cytoband C3
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:88647315-88688474 bp, + strand
From VEGA annotation of GRCm38

  41160 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:11156  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: caspase recruitment domain-containing protein, Nod1/Nod2 types
Gene Tree: Nod2

Human
homologs
Human Homolog NOD2, nucleotide-binding oligomerization domain containing 2
NCBI Gene ID 64127
neXtProt AC  NX_Q9HC29
Human Synonyms  ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1
Human Chr (Location)  16q21; chr16:50693596-50733079 (+)  GRCh38
Disease Associations  (4) Diseases Associated with Human NOD2
Alleles
and
phenotypes
All alleles(7) : Targeted(7)
 
Mice homozygous for a knock-out allele exhibit abnormal immune system morphology and physiology and increased susceptibility to induced colitis.
 
Human Diseases Modeled Using Mouse Nod2 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (121 annotations)
Process activation of immune response, activation of MAPK activity involved in innate immune response, ...
Component cell surface, COP9 signalosome, ...
Function ATP binding, CARD domain binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(9) cDNA(8) Other(1)
Microarray probesets(1)
Other database
links
VEGA Gene ModelOTTMUSG00000029844 (Evidence)
Ensembl Gene ModelENSMUSG00000055994 (Evidence)
Entrez Gene257632 (Evidence)
UniGene222633
DFCITC1582085, TC1602999
DoTSDT.101218676, DT.101383071, DT.91424028, DT.99844297
NIA Mouse Gene IndexU040711
Consensus CDS ProjectCCDS52632.1
International Mouse Knockout Project StatusNod2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029844 VEGA Gene Model | MGI Sequence Detail 41160 C57BL/6J ±  kb
transcript OTTMUST00000074063 VEGA | MGI Sequence Detail 4719 Not Applicable 
polypeptide OTTMUSP00000038426 VEGA | MGI Sequence Detail 1035 Not Applicable 

For the selected sequences
All sequences(498) RefSeq(8) UniProt(7)
Polymorphisms SNPs within 2kb(589 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001315 Caspase Recruitment
InterPro IPR011029 Death-like domain
InterPro IPR018228 Deoxyribonuclease, TatD-related, conserved site
InterPro IPR007111 NACHT nucleoside triphosphatase
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000011306 nucleotide-binding oligomerization domain-containing protein 2
References (Earliest) J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
(Latest) J:207016 Selvanantham T, et al., Nod1 and Nod2 enhance TLR-mediated invariant NKT cell activation during bacterial infection. J Immunol. 2013 Dec 1;191(11):5646-54
All references(152)
Other
accession IDs
MGI:2443828

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory