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Nod2 Gene Detail
Summary
  • Symbol
    Nod2
  • Name
    nucleotide-binding oligomerization domain containing 2
  • Synonyms
    Card15, F830032C23Rik, Nlrc2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2429397
    NCBI Gene: 257632
  • Gene Overview
    MyGene.info: NOD2
Location & Maps
more
  • Sequence Map
    Chr8:88647315-88688474 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      41160 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 43.51 cM, cytoband C3
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    NOD2, nucleotide binding oligomerization domain containing 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    NOD2, nucleotide binding oligomerization domain containing 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ACUG, BLAU, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1
  • Links
    NCBI Gene ID: 64127
    neXtProt AC: NX_Q9HC29

  • Chr Location
    16q21; chr16:50693581-50733081 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Nod2 mouse models; 4 with human NOD2 associations

Human Disease Mouse Models
       Inflammatory Bowel Disease 1; IBD1   OMIM: 266600 View 1 model
       Blau Syndrome; BLAUS   OMIM: 186580
Psoriatic Arthritis, Susceptibility to Psoriatic Arthritis, Susceptibility to, 1; PSORAS1   OMIM: 607507
Sarcoidosis, Early-Onset   OMIM: 609464
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 6 alleles in 8 genetic backgrounds
    4 phenotypes from multigenic genotypes
    138 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    9
  • Radiation induced
    1
  • Targeted
    8
  • Genomic Mutations
    1 involving Nod2
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit abnormal immune system morphology and physiology and increased susceptibility to induced colitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029844 VEGA Gene Model | MGI Sequence Detail 41160 C57BL/6J ±  kb
transcript OTTMUST00000074063 VEGA | MGI Sequence Detail 4719 Not Applicable  
polypeptide OTTMUSP00000038426 VEGA | MGI Sequence Detail 1035 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    585 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000011306 nucleotide-binding oligomerization domain-containing protein 2
  • InterPro Domains
    IPR001315 CARD domain
    IPR011029 Death-like domain
    IPR018228 Deoxyribonuclease, TatD-related, conserved site
    IPR001611 Leucine-rich repeat
    IPR032675 Leucine-rich repeat domain, L domain-like
    IPR007111 NACHT nucleoside triphosphatase
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 9
    cDNA 8
    Other 1

    Microarray probesets 1
Other
Accession IDs
less
MGI:2443828
References
more
  • Summaries
    All 165
    Diseases 1
    Gene Ontology 24
    Phenotypes 138
  • Earliest
    J:80000 The FANTOM Consortium and The RIKEN Genome Exploration Research Group Phase I & II Team, Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Nature. 2002;420:563-573
  • Latest
    J:230689 Dugan J, et al., Blau syndrome-associated Nod2 mutation alters expression of full-length NOD2 and limits responses to muramyl dipeptide in knock-in mice. J Immunol. 2015 Jan 1;194(1):349-57

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory