Symbol
Name
ID

Nod2
nucleotide-binding oligomerization domain containing 2
MGI:2429397

Phenotype annotations related to homeostasis/metabolism

Darker colors indicate more annotations

Human Phenotypes

Pedal edema

Hyperbilirubinemia

Increased LDL cholesterol concentration

Hypercholesterolemia

Hypertriglyceridemia

Elevated circulating C-reactive protein concentration

Elevated circulating amyloid A concentration

Elevated circulating hepatic transaminase concentration

Elevated circulating alkaline phosphatase concentration

Elevated erythrocyte sedimentation rate

Glucose intolerance

Diabetes mellitus

Type II diabetes mellitus

Impaired glucose tolerance

Joint swelling

Cystoid macular edema

Pleural effusion

Fever

Recurrent fever

Hematuria

Pyuria

Decreased level of D-mannose in urine

Proteinuria

Amyloidosis

Renal amyloidosis

Ascites

Disease(s) Associated with NOD2

Behcet's disease

Blau syndrome

coronary artery disease

familial mediterranean fever

graft-versus-host disease

systemic lupus erythematosus

Mouse Phenotypes		abnormal autophagy	increased circulating interferon-gamma level	increased circulating interleukin-2 level	increased circulating tumor necrosis factor level	abnormal cytokine level	abnormal interferon level	abnormal interleukin level	abnormal tumor necrosis factor level	increased susceptibility to xenobiotic induced morbidity/mortality
Availability	Mouse Genotype	abnormal autophagy	increased circulating interferon-gamma level	increased circulating interleukin-2 level	increased circulating tumor necrosis factor level	abnormal cytokine level	abnormal interferon level	abnormal interleukin level	abnormal tumor necrosis factor level
	Nod2^tm1Daph/Nod2^tm1Daph
	Nod2^tm1Flv/Nod2^tm1Flv
	Nod2^tm1Jhgt/Nod2^tm1Jhgt
	Nod2^tm1Mka/Nod2^tm1Mka

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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