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Nod2 Gene Detail
Summary
  • Symbol
    Nod2
  • Name
    nucleotide-binding oligomerization domain containing 2
  • Synonyms
    Card15, F830032C23Rik, Nlrc2
  • Feature Type
    protein coding gene
  • IDs
    MGI:2429397
    NCBI Gene: 257632
  • Alliance
    genome feature page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:89373943-89415102 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 43.51 cM, cytoband C3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1246 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2429397
 protein coding gene Chr8:89373943-89415103 (+)
129S1/SvImJ ENSMUSG00200016421
 protein coding gene Chr8:83729913-83770906 (+)
A/J ENSMUSG00195025645
 protein coding gene Chr8:84100996-84142169 (+)
AKR/J ENSMUSG00220038942
 protein coding gene Chr8:84128921-84169927 (+)
BALB/cJ ENSMUSG00180022245
 protein coding gene Chr8:83933497-83974493 (+)
C3H/HeJ ENSMUSG00175025072
 protein coding gene Chr8:84039824-84081002 (+)
C57BL/6NJ ENSMUSG00215022622
 protein coding gene Chr8:83641250-83682433 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031360
 protein coding gene Chr8:80179619-80220391 (+)
CAST/EiJ ENSTCUG00005016616
 protein coding gene Chr8:83502477-83543340 (+)
CBA/J ENSMUSG00210032550
 protein coding gene Chr8:84004841-84045754 (+)
DBA/2J ENSMUSG00185037558
 protein coding gene Chr8:90113429-90154338 (+)
FVB/NJ ENSMUSG00205015955
 protein coding gene Chr8:83060655-83101567 (+)
JF1/MsJ ENSUMUG00000033389
 protein coding gene Chr8:92435263-92476421 (+)
LP/J ENSMUSG00230027341
 protein coding gene Chr8:93732128-93764375 (+)
NOD/ShiLtJ ENSMUSG00190014843
 protein coding gene Chr8:84094100-84135070 (+)
NZO/HlLtJ ENSMUSG00225039245
 protein coding gene Chr8:97136207-97167823 (+)
PWK/PhJ ENSLUMG00010037619
 protein coding gene Chr8:83745638-83786820 (+)
SPRET/EiJ ENSMSPG00010025283
 protein coding gene Chr8:85685310-85725405 (+)
WSB/EiJ ENSIUOG00005019055
 protein coding gene Chr8:84825490-84866384 (+)



Homology
more
  • Human Ortholog
    NOD2, nucleotide binding oligomerization domain containing 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NOD2, nucleotide binding oligomerization domain containing 2
  • Synonyms
    ACUG, BLAU, BLAUS, CARD15, CD, CLR16.3, IBD1, NLRC2, NOD2B, PSORAS1, YAOS
  • Links
    NCBI Gene ID: 64127
    UniProt: Q9HC29

  • Chr Location
    16q12.1; chr16:50693217-50733348 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Nod2 mouse models; 26 with human NOD2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
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Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 7 alleles in 9 genetic backgrounds
    4 phenotypes from multigenic genotypes
    255 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal immune system morphology and physiology and increased susceptibility to induced colitis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    195
  • GO References
    38
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    597
  • cDNA Data
    9
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000055994 Ensembl Gene Model | MGI Sequence Detail 41160 C57BL/6J ±  kb
    transcript ENSMUST00000054324 Ensembl | MGI Sequence Detail 4719 Not Applicable  
    polypeptide ENSMUSP00000050538 Ensembl | MGI Sequence Detail 1035 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 9
      cDNA 9

      Microarray probesets 1
    Other
    Accession IDs
    less
    MGI:2443828
    References
    more
    • Summaries
      All 377
      Developmental Gene Expression 1
      Diseases 1
      Gene Ontology 38
      Phenotypes 255
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:391695 Vasilew K, et al., Polyphosphates Attenuate Interleukin-12 Production in Macrophages Infected With Legionella pneumophila. FASEB J. 2026 Jun 15;40(11):e71954
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory