Go Annotations as Summary Text (Tabular View) (GO Graph)

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Automated description from the Alliance of Genome Resources (Release 9.0.0)

Enables muramyl dipeptide binding activity and pattern recognition receptor activity. Involved in several processes, including host-mediated modulation of intestinal microbiota composition; intestinal stem cell homeostasis; and positive regulation of signal transduction. Acts upstream of or within several processes, including regulation of cytokine production; regulation of signal transduction; and response to bacterium. Predicted to be located in several cellular components, including basolateral plasma membrane; cell surface; and phagocytic vesicle. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Predicted to be extrinsic component of plasma membrane. Used to study inflammatory bowel disease 1. Human ortholog(s) of this gene implicated in several diseases, including Blau syndrome; autoimmune disease (multiple); familial Mediterranean fever; intestinal disease (multiple); and lung disease (multiple). Orthologous to human NOD2 (nucleotide binding oligomerization domain containing 2).

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Gene Ontology Evidence Code Abbreviations:

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