Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

Phenotypes:

Affected Systems	cn1	cn2	cn3	cn4	cn5	cn6	cn7	cn8	cn9	cn10	cn11	cn12	cn13	cn14	cn15	cn16	cn17	cn18	cn19	cn20	cn21	cn22	cn23	cn24	cn25	cn26	cn27	cn28	cn29	cn30	cn31	cn32	cn33	cn34	cn35		cn36	cn37	cn38	cn39	cn40	cn41	cn42	cn43	cn44	cn45	cn46
show or hide all annotated terms Sex:
adipose tissue																																							√
decreased subcutaneous adipose tissue amount																																							√
behavior/neurological				√																					√															√
absent gastric milk in neonates				√																																				√
abnormal mechanical nociception																									√
cardiovascular system																											√
abnormal blood vessel morphology																											√
abnormal skin vasculature morphology																											√
abnormal tumor vascularization																											√
abnormal cardiovascular system physiology																											√
cellular							√	√			√	√				√		√						√							√								√			√					√
aneuploidy																																															√
decreased keratinocyte adhesion																								√
increased hair follicle apoptosis								√
abnormal keratinocyte differentiation																																							√
decreased cell proliferation																√		√
decreased keratinocyte proliferation							√	√				√
increased cell proliferation											√							√
increased keratinocyte proliferation																															√								√			√
abnormal mitochondrial physiology																																							√
abnormal redox activity																																							√
craniofacial				√	√					√	√		√							N								√												√				N
craniofacial phenotype																				N																								N
abnormal cranium morphology													√
absent alveolar process													√
abnormal incisor morphology													√															√
abnormal lower incisor morphology													√
small incisors													√
abnormal molar morphology																												√
abnormal molar cusp morphology													√															√
fused molars																												√
small molars													√
abnormal enamel organ morphology																												√
abnormal stellate reticulum morphology																												√
abnormal inner dental epithelium morphology																												√
abnormal outer dental epithelium morphology																												√
absent enamel cord													√															√
arrest of tooth development													√
growth retardation of incisors													√
growth retardation of molars													√
abnormal dentin morphology													√
abnormal odontoblast morphology													√
abnormal enamel morphology													√
abnormal ameloblast morphology													√															√
absent Tomes' process																												√
abnormal nasal bone morphology													√
abnormal palate development										√
abnormal primary and secondary palatal fusion																																								√
abnormal secondary palate development																																								√
abnormal palatal shelf morphology				√
abnormal palatal shelf fusion at midline													√
persistence of medial edge epithelium during palatal shelf fusion																																								√
palatal shelf hypoplasia													√
abnormal secondary palate morphology																																								√
abnormal hard palate morphology																																								√
abnormal soft palate muscle morphology																																								√
abnormal tensor veli palatini muscle morphology																																								√
cleft secondary palate													√
submucous cleft palate										√																														√
anterior cleft palate				√						√
abnormal tongue epithelium morphology											√
increased mouth tumor incidence					√
digestive/alimentary system				√						√	√		√																		√									√
abnormal palate development										√
abnormal primary and secondary palatal fusion																																								√
abnormal secondary palate development																																								√
abnormal palatal shelf morphology				√
abnormal palatal shelf fusion at midline													√
persistence of medial edge epithelium during palatal shelf fusion																																								√
palatal shelf hypoplasia													√
abnormal secondary palate morphology																																								√
abnormal hard palate morphology																																								√
abnormal soft palate muscle morphology																																								√
abnormal tensor veli palatini muscle morphology																																								√
cleft secondary palate													√
submucous cleft palate										√																														√
anterior cleft palate				√						√
abnormal tongue epithelium morphology											√
abnormal esophagus morphology																															√
dilated esophagus																															√
aerophagia													√
endocrine/exocrine glands	√				√	√																				√			√				√	√	√				√					√		√
endocrine/exocrine gland phenotype	N
abnormal mammary gland development																													√
abnormal mammary gland growth during pregnancy																																		√	√
abnormal mammary gland epithelium morphology	√
abnormal mammary duct terminal end bud morphology	√
mammary gland duct hyperplasia	√
abnormal mammary gland alveolus morphology																													√
mammary gland alveolar hyperplasia	√
decreased mammary gland tumor incidence																																														√
increased mammary gland tumor incidence					√	√																											√
increased mammary adenocarcinoma incidence																										√
absent sebaceous gland																																							√
small sebaceous gland																																												√
decreased eccrine gland number																																												√
abnormal lactation																																		√
lactation failure																																			√
anhidrosis																																												√
growth/size/body				√	√			√		√	√	√	√											√			√	√			√								√	√				√
absent alveolar process													√
abnormal incisor morphology													√															√
abnormal lower incisor morphology													√
small incisors													√
abnormal molar morphology																												√
abnormal molar cusp morphology													√															√
fused molars																												√
small molars													√
abnormal enamel organ morphology																												√
abnormal stellate reticulum morphology																												√
abnormal inner dental epithelium morphology																												√
abnormal outer dental epithelium morphology																												√
absent enamel cord													√															√
arrest of tooth development													√
growth retardation of incisors													√
growth retardation of molars													√
abnormal dentin morphology													√
abnormal odontoblast morphology													√
abnormal enamel morphology													√
abnormal ameloblast morphology													√															√
absent Tomes' process																												√
abnormal nasal bone morphology													√
abnormal palate development										√
abnormal primary and secondary palatal fusion																																								√
abnormal secondary palate development																																								√
abnormal palatal shelf morphology				√
abnormal palatal shelf fusion at midline													√
persistence of medial edge epithelium during palatal shelf fusion																																								√
palatal shelf hypoplasia													√
abnormal secondary palate morphology																																								√
abnormal hard palate morphology																																								√
abnormal soft palate muscle morphology																																								√
abnormal tensor veli palatini muscle morphology																																								√
cleft secondary palate													√
submucous cleft palate										√																														√
anterior cleft palate				√						√
abnormal tongue epithelium morphology											√
increased mouth tumor incidence					√
epidermal cyst																								√
decreased body size								√																			√																	√
decreased body weight																															√
slow postnatal weight gain																																							√
postnatal growth retardation												√																			√													√
hematopoietic system																														√
decreased erythrocyte cell number																														√
increased granulocyte number																														√
decreased B cell number																														√
increased NK T cell number																														√
homeostasis/metabolism	√											√		√				√	√			√								√	√	√
abnormal circulating chemokine level																															√
increased circulating interleukin-1 alpha level																															√
increased circulating interleukin-17 level																														√	√
increased circulating interleukin-6 level																															√
increased circulating tumor necrosis factor level																															√
dehydration																						√
skin edema												√
impaired skin barrier function														√				√				√									√
increased incidence of tumors by chemical induction	√																															√
abnormal wound healing																			√
immune system												√			√												√			√	√										√
increased granulocyte number																														√
decreased B cell number																														√
increased NK T cell number																														√
abnormal circulating chemokine level																															√
increased circulating interleukin-1 alpha level																															√
increased circulating interleukin-17 level																														√	√
increased circulating interleukin-6 level																															√
increased circulating tumor necrosis factor level																															√
enlarged inguinal lymph nodes																														√
abnormal lymphatic vessel morphology																											√
abnormal lymphangiogenesis																											√
lymphatic vessel hyperplasia																											√
increased susceptibility to type IV hypersensitivity reaction																														√
increased interleukin-17 secretion																														√
skin inflammation												√																			√
dermatitis																															√
erythroderma															√
increased susceptibility to bacterial infection																															√										√
integument	√				√	√	√	√	√		√	√	√	√	√	√	√	√			√	√	√	√		√	√		√		√		√	√	√	N	√	N	√		√	√	N	√	N	√	√
integument phenotype																								N											N	N		N				N	N		N
decreased subcutaneous adipose tissue amount																																							√
abnormal mammary gland development																													√
abnormal mammary gland growth during pregnancy																																		√	√
abnormal mammary gland epithelium morphology	√
abnormal mammary duct terminal end bud morphology	√
mammary gland duct hyperplasia	√
abnormal mammary gland alveolus morphology																													√
mammary gland alveolar hyperplasia	√
decreased mammary gland tumor incidence																																														√
increased mammary gland tumor incidence					√	√																											√
increased mammary adenocarcinoma incidence																										√
absent sebaceous gland																																							√
small sebaceous gland																																												√
decreased eccrine gland number																																												√
abnormal lactation																																		√
lactation failure																																			√
anhidrosis																																												√
abnormal coat/ hair morphology																																												√
abnormal coat appearance																											√
abnormal hair growth											√	√																														√
alopecia								√									√														√
delayed hair appearance																																												√
hairless																																															√
progressive hair loss																																							√
sparse hair														√										√																				√
waved hair															√						√
abnormal hair shaft morphology								√																																				√
abnormal hair follicle morphology																							√				√																	√			√
abnormal hair follicle development												√
underdeveloped hair follicles							√	√
abnormal hair follicle orientation								√							√
abnormal hair follicle bulge morphology																																															√
decreased hair follicle number								√	√			√		√																									√
small hair follicles																																												√
abnormal vibrissa follicle morphology																																												√
absent vibrissae													√
curly vibrissae															√																													√
abnormal hair cycle anagen phase																																					√
abnormal hair cycle catagen phase																																							√
abnormal hair follicle physiology												√																																			√
increased hair follicle apoptosis								√
abnormal skin morphology																√																									√
abnormal skin vasculature morphology																											√
abnormal epidermal layer morphology											√	√		√		√		√				√																									√
abnormal epidermis stratum basale morphology																		√
thin epidermis stratum basale																		√
abnormal epidermis stratum corneum morphology															√			√				√
abnormal corneocyte envelope morphology															√
hyperkeratosis											√																																				√
abnormal epidermis stratum granulosum morphology														√
thin epidermis stratum granulosum														√
abnormal epidermis stratum spinosum morphology														√
acantholysis																								√
acanthosis												√
abnormal keratinocyte morphology								√
abnormal keratinocyte differentiation																																							√
absent epidermis																								√
epidermal hyperplasia																								√							√
thick epidermis											√																				√								√
thin epidermis									√					√				√
abnormal skin appearance																															√
blistering												√												√
dry skin															√																√
reddish skin														√													√
scaly skin												√			√																√
skin lesions																								√
wrinkled skin											√											√									√
abnormal skin pigmentation												√
abnormal skin condition																		√
epidermal cyst																								√
skin edema												√
thick skin											√
thin skin												√				√		√																										√
abnormal skin development														√																														√
abnormal epidermal stem cell morphology											√							√
decreased epidermal stem cell number														√
increased skin tumor incidence					√
increased skin squamous cell carcinoma incidence											√
abnormal skin physiology									√																																						√
impaired skin barrier function														√				√				√									√
skin inflammation												√																			√
dermatitis																															√
erythroderma															√
abnormal keratinocyte physiology																																							√
decreased keratinocyte adhesion																								√
decreased keratinocyte proliferation							√	√				√
increased keratinocyte proliferation																															√								√			√
decreased skin tensile strength												√
limbs/digits/tail																																												√
decreased eccrine gland number																																												√
interdigital webbing																																												√
mortality/aging							√					√	√	√		√						√		√				√			√				N	N			√	√							√
mortality/aging																																			N	N
decreased survivor rate																								√
premature death																															√								√
neonatal lethality, complete penetrance							√						√			√												√												√
postnatal lethality, complete penetrance												√		√								√
neonatal lethality, incomplete penetrance																								√
postnatal lethality, incomplete penetrance																																															√
muscle																																								√
abnormal soft palate muscle morphology																																								√
abnormal tensor veli palatini muscle morphology																																								√
neoplasm	√				√	√					√															√	√					√	√													√
neoplasm																																N
increased mouth tumor incidence					√
decreased mammary gland tumor incidence																																														√
increased mammary gland tumor incidence					√	√																											√
increased mammary adenocarcinoma incidence																										√
increased incidence of tumors by chemical induction	√																															√
increased skin tumor incidence					√
increased skin squamous cell carcinoma incidence											√
abnormal tumor pathology																																√
abnormal tumor vascularization																											√
decreased metastatic potential																																	√
increased metastatic potential	√																									√	√
abnormal tumor morphology					√
decreased tumor latency					√	√																										√
nervous system																							N		√
nervous system phenotype																							N
abnormal nervous system electrophysiology																									√
pigmentation		N	N									√
pigmentation phenotype		N	N
abnormal skin pigmentation												√
reproductive system																																		√	√
abnormal mammary gland growth during pregnancy																																		√	√
respiratory system													√
abnormal nasal bone morphology													√
skeleton													√															√
skeleton phenotype													N
abnormal cranium morphology													√
absent alveolar process													√
abnormal incisor morphology													√															√
abnormal lower incisor morphology													√
small incisors													√
abnormal molar morphology																												√
abnormal molar cusp morphology													√															√
fused molars																												√
small molars													√
abnormal enamel organ morphology																												√
abnormal stellate reticulum morphology																												√
abnormal inner dental epithelium morphology																												√
abnormal outer dental epithelium morphology																												√
absent enamel cord													√															√
arrest of tooth development													√
growth retardation of incisors													√
growth retardation of molars													√
abnormal dentin morphology													√
abnormal odontoblast morphology													√
abnormal enamel morphology													√
abnormal ameloblast morphology													√															√
absent Tomes' process																												√
abnormal nasal bone morphology													√
vision/eye													√						√																									√
vision/eye phenotype																			N
abnormal cornea epithelium morphology																			√
decreased cornea epithelium thickness																			√
decreased cornea thickness																			√
delayed eyelid opening																																												√
eyelids open at birth													√