Dgat1^tm2Far
Targeted Allele Detail

Summary

• Symbol: Dgat1^tm2Far
• Name: diacylglycerol O-acyltransferase 1; targeted mutation 2, Bob Farese
• MGI ID: MGI:3842432
• Synonyms: Dgat1^flox
• Gene: Dgat1 Location: Chr15:76386215-76396153 bp, - strand Genetic Position: Chr15, 35.99 cM
• Alliance: Dgat1^tm2Far page

Cyclical alopecia in Dgat1^tm2Far/Dgat1^tm2Far Tg(KRT14-cre)1Amc/? mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147611
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: Exons 14 to 17 were flanked by loxP sites and an frt flanked GK-neo selection cassette was inserted in a 3' position. The neomycin selection cassette was subsequently excised using an unspecified Actin-FLPe construct. (J:147611, J:225403)

Generation of the Dgat1^tm2Far allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dgat1 Mutation: 32 strains or lines available

References

• Original: J:147611 Shih MY, et al., Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin. J Biol Chem. 2009 Feb 13;284(7):4292-9
• All: 11 reference(s)