Phenotypes for Fntb Pggt1b Tg(KRT14-cre)1Amc MGI:4442843 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Fntb^tm1.1Mbrg/Fntb^tm1.1Mbrg Pggt1b^tm1Mbrg/Pggt1b^tm1Mbrg Tg(KRT14-cre)1Amc/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fntb^tm1.1Mbrg mutation (0 available); any Fntb mutation (208 available)
Pggt1b^tm1Mbrg mutation (0 available); any Pggt1b mutation (26 available)
Tg(KRT14-cre)1Amc mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

decreased hair follicle number ( J:158528 )

• at E17.5 embryos have fewer hair follicles

thin epidermis ( J:158528 )

• interfollicular epidermis is slightly thinner compared to either single mutant at E17.5

abnormal skin physiology ( J:158528 )

• at E17.5 more apoptotic cells are present than in either single mutant

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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