Phenotypes Associated with This Genotype

Genotype
MGI:5009418

cn12

• Allelic Composition: Ilk^tm1Star/Ilk^tm1Star; Tg(KRT14-cre)1Amc/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:172934 )

• median survival is 4 days

integument

decreased keratinocyte proliferation ( J:172934 )

• in culture

skin edema ( J:172934 )

skin inflammation ( J:172934 )

abnormal hair growth ( J:172934 )

• by P3

abnormal hair follicle development ( J:172934 )

• hair follicles exhibit severe growth retardation compared to in control mice

• no follicles are apparent beyond stage 4 unlike in control mice

decreased hair follicle number ( J:172934 )

• at P4

abnormal hair follicle physiology ( J:172934 )

• hair follicles exhibit decreased cell proliferation compared to in control mice

abnormal epidermal layer morphology ( J:172934 )

• mice exhibit increased intracellular epidermal spaces compared with control mice

acanthosis ( J:172934 )

blistering ( J:172934 )

• mice exhibit microblisters at the junction of the basal layer and the basement membrane on different parts of the body, including dorsal skin, the footpads, and along the forelimbs and hindlimbs, unlike in control mice

• blisters are more common in areas of high friction

scaly skin ( J:172934 )

abnormal skin pigmentation ( J:172934 )

• reduced as early as P1

thin skin ( J:172934 )

decreased skin tensile strength ( J:172934 )

• fragile skin

homeostasis/metabolism

skin edema ( J:172934 )

growth/size/body

postnatal growth retardation ( J:172934 )

• as early as P1

immune system

skin inflammation ( J:172934 )

pigmentation

abnormal skin pigmentation ( J:172934 )

• reduced as early as P1

cellular

decreased keratinocyte proliferation ( J:172934 )

• in culture