Phenotypes Associated with This Genotype

Genotype
MGI:6112650

cn14

• Allelic Composition: Slc39a10^tm1.1Tfk/Slc39a10^tm1.1Tfk; Tg(KRT14-cre)1Amc/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:254216 )

• die within a few days of birth

integument

impaired skin barrier function ( J:254216 )

• particularly in the ventral skin

sparse hair ( J:254216 )

• newborns have thin and feeble hair

decreased hair follicle number ( J:254216 )

• at P1

abnormal epidermal layer morphology ( J:254216 )

• epidermal dysgenesis with dorsal epidermal hypoplasia and ventral embryonic epidermis at P1

abnormal epidermis stratum granulosum morphology ( J:254216 )

• ventral skin lacks a granular layer at P1

thin epidermis stratum granulosum ( J:254216 )

• in the dorsal skin at P1

abnormal epidermis stratum spinosum morphology ( J:254216 )

• ventral skin lacks a spinous layer at P1

thin epidermis ( J:254216 )

• in the dorsal skin the epidermal layer appears atrophic with thinning of the granular layer at P1

reddish skin ( J:254216 )

• newborns have scarlet skin

abnormal skin development ( J:254216 )

• expression analysis indicates a defect in epidermal differentiation

decreased epidermal stem cell number ( J:254216 )

• decrease in the number of Trp63+ epidermal progenitor cells in the hair follicle and interfollicular region at P1

homeostasis/metabolism

impaired skin barrier function ( J:254216 )

• particularly in the ventral skin