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Transgene Detail
Symbol: Tg(MMTV-PyVT)634Mul
Name: transgene insertion 634, William Muller
MGI ID: MGI:2679595
Synonyms: MMTV-PyMT, MMTV-PyVmT, MT634, MTAG, PyMT, PyV-mT, PyVT, Tg(MMTVPyVT)634Mul, TgN(MMTVPyVT)634Mul, TgN(MMTVPyVT)634Mul
Transgene: Tg(MMTV-PyVT)634Mul  Location: unknown  
Alliance: Tg(MMTV-PyVT)634Mul page
A basal-like subtype of mammary tumors in Adipoqtm1Chan/Adipoq+ Tg(MMTV-PyVT)634Mul/0 mice

Show the 4 phenotype image(s) involving this allele.

Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Mutation detailsThis transgene expresses polyoma virus middle T antigen under the control of the mouse mammary tumor virus LTR. Expression of this transgene was detected at high levels in male and female mammary glands. Other expression sites include salivary gland, seminal vesicles, ovaries, and lung. (J:46460)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 2 anatomical structures
Tumor Data
List all tumor models in MMHCdb carrying Tg(MMTV-PyVT)634Mul
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Additional lines produced include lines 121, 196, 235, 654, 668, 670.

These mice are used to study metastatic disease.

Original:  J:46460 Guy CT, et al., Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Mol Cell Biol. 1992 Mar;12(3):954-61
All:  565 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
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