Nmi^tm1.1Geno
Targeted Allele Detail

Summary

• Symbol: Nmi^tm1.1Geno
• Name: N-myc (and STAT) interactor; targeted mutation 1.1, Genoway
• MGI ID: MGI:6402447
• Synonyms: Nmi^fl
• Gene: Nmi Location: Chr2:51838510-51863505 bp, - strand Genetic Position: Chr2, 29.98 cM, cytoband C1
• Alliance: Nmi^tm1.1Geno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:261035
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site and an FRT site flanked neomycin resistance gene cassette were inserted into intron 7, and a second loxP site downstream of exon 9 (the last exon). The neo cassette was subsequently deleted through flp-mediated recombination, leaving a conditional-ready allele with exons 8 and 9 floxed. (J:261035)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nmi Mutation: 22 strains or lines available

References

• Original: J:261035 Pruitt HC, et al., Conditional knockout of N-Myc and STAT interactor disrupts normal mammary development and enhances metastatic ability of mammary tumors. Oncogene. 2018 Mar;37(12):1610-1623
• All: 1 reference(s)