Phenotypes associated with this allele

• Allele Symbol: Nmi^tm1.1Geno
• Allele Name: targeted mutation 1.1, Genoway
• Allele ID: MGI:6402447
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nmi^tm1.1Geno/Nmi^tm1.1Geno Tg(KRT14-cre)1Amc/0	B6.Cg-Nmi^tm1.1Geno Tg(KRT14-cre)1Amc	MGI:6402593
cn2	Nmi^tm1.1Geno/Nmi^tm1.1Geno Tg(KRT14-cre)1Amc/0 Tg(MMTVneu)202Mul/0	involves: 129S/SvEv * C57BL/6 * CBA * FVB/N	MGI:6402594

Genotype
MGI:6402593

cn1

• Allelic Composition: Nmi^tm1.1Geno/Nmi^tm1.1Geno; Tg(KRT14-cre)1Amc/0
• Genetic Background: B6.Cg-Nmi^tm1.1Geno Tg(KRT14-cre)1Amc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:261035 )

N • normal lactation

abnormal mammary gland epithelium morphology ( J:261035 )

• more proliferative at lactation day 1

abnormal mammary duct terminal end bud morphology ( J:261035 )

• increased terminal end bud number

mammary gland duct hyperplasia ( J:261035 )

• enhanced ductal extension during pubertal mammary development

mammary gland alveolar hyperplasia ( J:261035 )

• prolific alveologenesis during mid pregnancy at day 14.5 post conception and at lactation day 1

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:261035 )

• 2x increase in lung metastatic nodules in DMBA-induced mammary tumor bearing mice

• invasive fronts of pre-neoplastic mammary lesions create microscopic projections of epithelial cells into surrounding stroma after induction with DMBA

• normal latency to mammary tumor growth after induction with DMBA

• normal mammary tumor growth rate after induction with DMBA

integument

abnormal mammary gland epithelium morphology ( J:261035 )

• more proliferative at lactation day 1

abnormal mammary duct terminal end bud morphology ( J:261035 )

• increased terminal end bud number

mammary gland duct hyperplasia ( J:261035 )

• enhanced ductal extension during pubertal mammary development

mammary gland alveolar hyperplasia ( J:261035 )

• prolific alveologenesis during mid pregnancy at day 14.5 post conception and at lactation day 1

neoplasm

increased incidence of tumors by chemical induction ( J:261035 )

• 2x increase in lung metastatic nodules in DMBA-induced mammary tumor bearing mice

• invasive fronts of pre-neoplastic mammary lesions create microscopic projections of epithelial cells into surrounding stroma after induction with DMBA

• normal latency to mammary tumor growth after induction with DMBA

• normal mammary tumor growth rate after induction with DMBA

increased metastatic potential ( J:261035 )

• 2x increase in lung metastatic nodules in DMBA-induced mammary tumor bearing mice

Genotype
MGI:6402594

cn2

• Allelic Composition: Nmi^tm1.1Geno/Nmi^tm1.1Geno; Tg(KRT14-cre)1Amc/0; Tg(MMTVneu)202Mul/0
• Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA * FVB/N

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:261035 )

• shorter latency to tumor formation

• accelerated tumor growth

• higher metastasis incidence

integument

increased mammary adenocarcinoma incidence ( J:261035 )

• shorter latency to tumor formation

• accelerated tumor growth

• higher metastasis incidence

neoplasm

increased mammary adenocarcinoma incidence ( J:261035 )

• shorter latency to tumor formation

• accelerated tumor growth

• higher metastasis incidence

increased metastatic potential ( J:261035 )

• increased pulmonary metastasis by mammary tumors