Phenotypes Associated with This Genotype

Genotype
MGI:5305779

cn22

• Allelic Composition: Gak^tm2Legr/Gak^tm2Legr; Tg(KRT14-cre)1Amc/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:180119 )

• mice die shortly after birth

integument

impaired skin barrier function ( J:180119 )

• at E17.5

abnormal epidermal layer morphology ( J:180119 )

• the epidermis lacks extensive differentiation and multiple cell layers compared with control mice

• the epidermis exhibits reduced neutral lipids compared with control mice

abnormal epidermis stratum corneum morphology ( J:180119 )

• underdeveloped

wrinkled skin ( J:180119 )

• shortly after birth

homeostasis/metabolism

dehydration ( J:180119 )

• shortly after birth

impaired skin barrier function ( J:180119 )

• at E17.5