Stk3^tm1Jav
Targeted Allele Detail

Summary

• Symbol: Stk3^tm1Jav
• Name: serine/threonine kinase 3; targeted mutation 1, Joseph Avruch
• MGI ID: MGI:4410615
• Synonyms: Mst2^F
• Gene: Stk3 Location: Chr15:34875645-35155990 bp, - strand Genetic Position: Chr15, 14.34 cM, cytoband B3.3
• Alliance: Stk3^tm1Jav page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:153945
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129 x C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exon 3. Following the 5' loxP site, a neomycin resistance cassette flanked by Frt sites was inserted in the intron before exon3. (J:153945)

Disease models

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Tumor Data

List all tumor models in MMHCdb carrying Stk3^tm1Jav

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stk3 Mutation: 47 strains or lines available

References

• Original: J:153945 Zhou D, et al., Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene. Cancer Cell. 2009 Nov 6;16(5):425-38
• All: 17 reference(s)