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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Stk3tm1Jav
targeted mutation 1, Joseph Avruch
MGI:4410615
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Stk3tm1Jav/Stk3tm1Jav
Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129 * 129P2/OlaHsd * C57BL/6 * DBA MGI:5824005
cn2
 		Stk3tm1.1Jav/Stk3tm1Jav
Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi 		involves: 129 * C57BL/6 MGI:4411990
cn3
 		Stk3tm1Jav/Stk3tm1Jav
Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129 * C57BL/6 MGI:4411991
cn4
 		Stk3tm1Jav/Stk3tm1Jav
Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi 		involves: 129 * C57BL/6 MGI:4411989
cn5
 		Stk3tm1Jav/Stk3tm1Jav
Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi
Tg(KRT14-cre)1Amc/0 		involves: C57BL/6 * CBA MGI:5316469


Genotype
MGI:5824005
cn1
Allelic
Composition		 Stk3tm1Jav/Stk3tm1Jav
Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129 * 129P2/OlaHsd * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
Stk3tm1Jav mutation (0 available); any Stk3 mutation (47 available)
Stk4Gt(AJ0315)Wtsi mutation (0 available); any Stk4 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
increased hepatocellular carcinoma incidence ( J:238319 )
• mice develop multiple spontaneous hepatocellular carcinomas

neoplasm
increased hepatocellular carcinoma incidence ( J:238319 )
• mice develop multiple spontaneous hepatocellular carcinomas

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
hepatocellular carcinoma DOID:684 OMIM:114550
 J:238319




Genotype
MGI:4411990
cn2
Allelic
Composition		 Stk3tm1.1Jav/Stk3tm1Jav
Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk3tm1.1Jav mutation (0 available); any Stk3 mutation (47 available)
Stk3tm1Jav mutation (0 available); any Stk3 mutation (47 available)
Stk4Gt(AJ0315)Wtsi mutation (0 available); any Stk4 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
increased hepatocyte proliferation ( J:153945 )
• 4-fold increase in hepatocyte proliferation by Ki-67 staining at day 8 after Adeno-Cre administration
liver hyperplasia ( J:153945 )
• injecting of Adenovirus expressing Cre recombinase (Adeno-Cre) into the tail vein at 6 weeks old to induce liver-specific deletion
• a prominent increase in liver size as early as 3 days after Adeno-Cre administration
• 2-fold larger at 8 days and 4-fold larger by 3 months
increased hepatocellular carcinoma incidence ( J:153945 )
• with a mean latency of 10 weeks after Adeno-Cre injection
• the presence of multifocal hepatocellular carcinomas (HCCs) against the backdrop of hyperplastic, but untransformed, hepatocytes

neoplasm
increased hepatocellular carcinoma incidence ( J:153945 )
• with a mean latency of 10 weeks after Adeno-Cre injection
• the presence of multifocal hepatocellular carcinomas (HCCs) against the backdrop of hyperplastic, but untransformed, hepatocytes

cellular
decreased sensitivity to induced cell death ( J:153945 )
• resistance to Fas-Induced Apoptosis in the liver as determined by histological examination, TUNEL staining and western blotting for cleaved caspase-3
increased hepatocyte proliferation ( J:153945 )
• 4-fold increase in hepatocyte proliferation by Ki-67 staining at day 8 after Adeno-Cre administration

growth/size/body
liver hyperplasia ( J:153945 )
• injecting of Adenovirus expressing Cre recombinase (Adeno-Cre) into the tail vein at 6 weeks old to induce liver-specific deletion
• a prominent increase in liver size as early as 3 days after Adeno-Cre administration
• 2-fold larger at 8 days and 4-fold larger by 3 months




Genotype
MGI:4411991
cn3
Allelic
Composition		 Stk3tm1Jav/Stk3tm1Jav
Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
Stk3tm1Jav mutation (0 available); any Stk3 mutation (47 available)
Stk4Gt(AJ0315)Wtsi mutation (0 available); any Stk4 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
liver hyperplasia ( J:153945 )
• develop massively overgrown livers by 3 months of age (4 out of 4)
increased hepatocellular carcinoma incidence ( J:153945 )
• develop hepatocellular carcinomas (HHCs) by 3 months of age (4 out of 4)

neoplasm
increased hepatocellular carcinoma incidence ( J:153945 )
• develop hepatocellular carcinomas (HHCs) by 3 months of age (4 out of 4)

growth/size/body
liver hyperplasia ( J:153945 )
• develop massively overgrown livers by 3 months of age (4 out of 4)




Genotype
MGI:4411989
cn4
Allelic
Composition		 Stk3tm1Jav/Stk3tm1Jav
Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk3tm1Jav mutation (0 available); any Stk3 mutation (47 available)
Stk4Gt(AJ0315)Wtsi mutation (0 available); any Stk4 mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
increased hepatocyte proliferation ( J:153945 )
• 4-fold increase in hepatocyte proliferation by Ki-67 staining at day 8 after Adeno-Cre administration
liver hyperplasia ( J:153945 )
• injecting of Adenovirus expressing Cre recombinase (Adeno-Cre) into the tail vein at 6 weeks old to induce liver-specific deletion
• a prominent increase in liver size as early as 3 days after Adeno-Cre administration
• 2-fold larger at 8 days and 4-fold larger by 3 months
increased hepatocellular carcinoma incidence ( J:153945 )
• with a mean latency of 10 weeks after Adeno-Cre injection
• the presence of multifocal hepatocellular carcinomas (HCCs) against the backdrop of hyperplastic, but untransformed, hepatocytes

neoplasm
increased hepatocellular carcinoma incidence ( J:153945 )
• with a mean latency of 10 weeks after Adeno-Cre injection
• the presence of multifocal hepatocellular carcinomas (HCCs) against the backdrop of hyperplastic, but untransformed, hepatocytes

cellular
increased hepatocyte proliferation ( J:153945 )
• 4-fold increase in hepatocyte proliferation by Ki-67 staining at day 8 after Adeno-Cre administration

growth/size/body
liver hyperplasia ( J:153945 )
• injecting of Adenovirus expressing Cre recombinase (Adeno-Cre) into the tail vein at 6 weeks old to induce liver-specific deletion
• a prominent increase in liver size as early as 3 days after Adeno-Cre administration
• 2-fold larger at 8 days and 4-fold larger by 3 months




Genotype
MGI:5316469
cn5
Allelic
Composition		 Stk3tm1Jav/Stk3tm1Jav
Stk4Gt(AJ0315)Wtsi/Stk4Gt(AJ0315)Wtsi
Tg(KRT14-cre)1Amc/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk3tm1Jav mutation (0 available); any Stk3 mutation (47 available)
Stk4Gt(AJ0315)Wtsi mutation (0 available); any Stk4 mutation (72 available)
Tg(KRT14-cre)1Amc mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
integument phenotype ( J:171057 )
N
• mice exhibit normal epidermal development




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory