Stk4^{Gt(AJ0315)Wtsi}
Gene trapped Allele Detail

Summary

• Symbol: Stk4^{Gt(AJ0315)Wtsi}
• Name: serine/threonine kinase 4; gene trap AJ0315, Wellcome Trust Sanger Institute
• MGI ID: MGI:3820519
• Synonyms: Mst1^-
• Gene: Stk4 Location: Chr2:163916033-163997444 bp, + strand Genetic Position: Chr2, 84.6 cM, cytoband H3
• Alliance: Stk4^{Gt(AJ0315)Wtsi} page

Mutation origin

• Mutant Cell Line: AJ0315
• Germline Transmission: Earliest citation of germline transmission: J:140710
• Parent Cell Line: E14TG2a.4 (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Sanger Inst. Gene Trap Res.

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0lxr
• Mutation details: The gene trap vector inserted between exons 1 and 2. The transcript consists of the first 70 bp of Stk4 fused to the reporter construct. Western blot analysis confirms the expression of a truncated protein. (J:140710)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  AJ0315	CL422935 ; (MGI Seq Detail)	5' RACE	Chr2:163916058-163916166 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  32 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Stk4^{Gt(AJ0315)Wtsi}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stk4 Mutation: 72 strains or lines available

References

• Original: J:140710 Anguera MC, et al., Characterization of two Mst1-deficient mouse models. Dev Dyn. 2008 Nov;237(11):3424-34
• All: 17 reference(s)