Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk4Gt(AJ0315)Wtsi mutation
(0 available);
any
Stk4 mutation
(72 available)
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immune system
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• in vivo, nave and effector T cells have an apoptosis rate that is twice that of controls
• effector T cells also have an increased rate in apoptosis in vitro after stimulation, though nave T cells have a decreased rate of apoptosis in vitro
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• naive T cells proliferate two- to five- fold greater in response to anti-CD3 while memory and effector T cells proliferate at a rate similar to controls
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• there is a marked reduction in the number of T cells displaying the CD62Lhi/CD44lo/ nave phenotype in the spleen, lymph nodes and circulation
• numbers of effector/memory T cells are similar or slightly increased in the secondary lymph node tissues compared to controls
• an increase in the number of CD4+ effector cells is observed in the lung
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• the percent and absolute numbers of CD4+ T cells in the blood are reduced by a half to two-thirds
• CD4+ T cell numbers are also reduced in the spleen
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• the percent and absolute numbers of CD8+ T cells in the blood are reduced by a half to two-thirds
• CD8+ T cell numbers are also reduced in the spleen
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• numbers of effector/memory T cells are similar or slightly increased in the secondary lymph node tissues compared to controls
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• the amount of white pulp is reduced
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• nave and effector CD4+ T cells have enhanced production of IFN-gamma in response to anti-CD3 stimulation
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• nave and effector CD4+ T cells have enhanced production of IL-2 in response to anti-CD3 stimulation
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• nave and effector CD4+ T cells have enhanced production of IL-4 in response to anti-CD3 stimulation
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hematopoietic system
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• in vivo, nave and effector T cells have an apoptosis rate that is twice that of controls
• effector T cells also have an increased rate in apoptosis in vitro after stimulation, though nave T cells have a decreased rate of apoptosis in vitro
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• naive T cells proliferate two- to five- fold greater in response to anti-CD3 while memory and effector T cells proliferate at a rate similar to controls
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• there is a marked reduction in the number of T cells displaying the CD62Lhi/CD44lo/ nave phenotype in the spleen, lymph nodes and circulation
• numbers of effector/memory T cells are similar or slightly increased in the secondary lymph node tissues compared to controls
• an increase in the number of CD4+ effector cells is observed in the lung
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• the percent and absolute numbers of CD4+ T cells in the blood are reduced by a half to two-thirds
• CD4+ T cell numbers are also reduced in the spleen
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• the percent and absolute numbers of CD8+ T cells in the blood are reduced by a half to two-thirds
• CD8+ T cell numbers are also reduced in the spleen
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• numbers of effector/memory T cells are similar or slightly increased in the secondary lymph node tissues compared to controls
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• the amount of white pulp is reduced
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cellular
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• in vivo, nave and effector T cells have an apoptosis rate that is twice that of controls
• effector T cells also have an increased rate in apoptosis in vitro after stimulation, though nave T cells have a decreased rate of apoptosis in vitro
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• naive T cells proliferate two- to five- fold greater in response to anti-CD3 while memory and effector T cells proliferate at a rate similar to controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk4Gt(AJ0315)Wtsi mutation
(0 available);
any
Stk4 mutation
(72 available)
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neoplasm
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• 2 out of 23 mice develop lethal histiocytic sarcomas over a period of 18-24 months
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk4Gt(AJ0315)Wtsi mutation
(0 available);
any
Stk4 mutation
(72 available)
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mortality/aging
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N |
• mice are viable and fertile
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Speer6-ps1Tg(Alb-cre)21Mgn mutation
(6 available);
any
Speer6-ps1 mutation
(4 available)
Stk3tm1Jav mutation
(0 available);
any
Stk3 mutation
(47 available)
Stk4Gt(AJ0315)Wtsi mutation
(0 available);
any
Stk4 mutation
(72 available)
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liver/biliary system
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• mice develop multiple spontaneous hepatocellular carcinomas
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neoplasm
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• mice develop multiple spontaneous hepatocellular carcinomas
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk3tm1Jav mutation
(0 available);
any
Stk3 mutation
(47 available)
Stk4Gt(AJ0315)Wtsi mutation
(0 available);
any
Stk4 mutation
(72 available)
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liver/biliary system
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• 4-fold increase in hepatocyte proliferation by Ki-67 staining at day 8 after Adeno-Cre administration
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• injecting of Adenovirus expressing Cre recombinase (Adeno-Cre) into the tail vein at 6 weeks old to induce liver-specific deletion
• a prominent increase in liver size as early as 3 days after Adeno-Cre administration
• 2-fold larger at 8 days and 4-fold larger by 3 months
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• with a mean latency of 10 weeks after Adeno-Cre injection
• the presence of multifocal hepatocellular carcinomas (HCCs) against the backdrop of hyperplastic, but untransformed, hepatocytes
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neoplasm
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• with a mean latency of 10 weeks after Adeno-Cre injection
• the presence of multifocal hepatocellular carcinomas (HCCs) against the backdrop of hyperplastic, but untransformed, hepatocytes
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cellular
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• 4-fold increase in hepatocyte proliferation by Ki-67 staining at day 8 after Adeno-Cre administration
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growth/size/body
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• injecting of Adenovirus expressing Cre recombinase (Adeno-Cre) into the tail vein at 6 weeks old to induce liver-specific deletion
• a prominent increase in liver size as early as 3 days after Adeno-Cre administration
• 2-fold larger at 8 days and 4-fold larger by 3 months
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk3tm1.1Jav mutation
(0 available);
any
Stk3 mutation
(47 available)
Stk3tm1Jav mutation
(0 available);
any
Stk3 mutation
(47 available)
Stk4Gt(AJ0315)Wtsi mutation
(0 available);
any
Stk4 mutation
(72 available)
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liver/biliary system
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• 4-fold increase in hepatocyte proliferation by Ki-67 staining at day 8 after Adeno-Cre administration
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• injecting of Adenovirus expressing Cre recombinase (Adeno-Cre) into the tail vein at 6 weeks old to induce liver-specific deletion
• a prominent increase in liver size as early as 3 days after Adeno-Cre administration
• 2-fold larger at 8 days and 4-fold larger by 3 months
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• with a mean latency of 10 weeks after Adeno-Cre injection
• the presence of multifocal hepatocellular carcinomas (HCCs) against the backdrop of hyperplastic, but untransformed, hepatocytes
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neoplasm
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• with a mean latency of 10 weeks after Adeno-Cre injection
• the presence of multifocal hepatocellular carcinomas (HCCs) against the backdrop of hyperplastic, but untransformed, hepatocytes
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cellular
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• resistance to Fas-Induced Apoptosis in the liver as determined by histological examination, TUNEL staining and western blotting for cleaved caspase-3
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• 4-fold increase in hepatocyte proliferation by Ki-67 staining at day 8 after Adeno-Cre administration
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growth/size/body
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• injecting of Adenovirus expressing Cre recombinase (Adeno-Cre) into the tail vein at 6 weeks old to induce liver-specific deletion
• a prominent increase in liver size as early as 3 days after Adeno-Cre administration
• 2-fold larger at 8 days and 4-fold larger by 3 months
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Speer6-ps1Tg(Alb-cre)21Mgn mutation
(6 available);
any
Speer6-ps1 mutation
(4 available)
Stk3tm1Jav mutation
(0 available);
any
Stk3 mutation
(47 available)
Stk4Gt(AJ0315)Wtsi mutation
(0 available);
any
Stk4 mutation
(72 available)
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liver/biliary system
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• develop massively overgrown livers by 3 months of age (4 out of 4)
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• develop hepatocellular carcinomas (HHCs) by 3 months of age (4 out of 4)
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neoplasm
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• develop hepatocellular carcinomas (HHCs) by 3 months of age (4 out of 4)
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growth/size/body
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• develop massively overgrown livers by 3 months of age (4 out of 4)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk3tm1Jav mutation
(0 available);
any
Stk3 mutation
(47 available)
Stk4Gt(AJ0315)Wtsi mutation
(0 available);
any
Stk4 mutation
(72 available)
Tg(KRT14-cre)1Amc mutation
(2 available)
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integument
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N |
• mice exhibit normal epidermal development
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk3tm1.1Jav mutation
(0 available);
any
Stk3 mutation
(47 available)
Stk4Gt(AJ0315)Wtsi mutation
(0 available);
any
Stk4 mutation
(72 available)
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neoplasm
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• highly aggressive hepatocellular carcinomas (HCCs)
• HCCs in 3 out of 12 mice by 15 months of age
• no mice (n = 6) have visible tumors among 7-month-old asymptomatic animals
• Western blotting, PCR analysis of HCCs reveals the absence of wild-type proteins and DNA of both alleles
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liver/biliary system
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• highly aggressive hepatocellular carcinomas (HCCs)
• HCCs in 3 out of 12 mice by 15 months of age
• no mice (n = 6) have visible tumors among 7-month-old asymptomatic animals
• Western blotting, PCR analysis of HCCs reveals the absence of wild-type proteins and DNA of both alleles
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk3tm1.1Jav mutation
(0 available);
any
Stk3 mutation
(47 available)
Stk4Gt(AJ0315)Wtsi mutation
(0 available);
any
Stk4 mutation
(72 available)
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behavior/neurological
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• starting at 7 months of age
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neoplasm
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• highly aggressive hepatocellular carcinomas (HCCs)
• HCCs in 6 out of 7 asymptomatic mice at 7 months old
• Western blotting, PCR analysis of HCCs reveals the absence of wild-type proteins and DNA of both alleles
• mice that show morbidity (13 out of 16 by 15 months old) harbor liver tumors
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liver/biliary system
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• some mice display overgrowth (2- to 4-fold) of the apparently normal liver tissue
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• highly aggressive hepatocellular carcinomas (HCCs)
• HCCs in 6 out of 7 asymptomatic mice at 7 months old
• Western blotting, PCR analysis of HCCs reveals the absence of wild-type proteins and DNA of both alleles
• mice that show morbidity (13 out of 16 by 15 months old) harbor liver tumors
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growth/size/body
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• some mice display overgrowth (2- to 4-fold) of the apparently normal liver tissue
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stk3tm1.1Jav mutation
(0 available);
any
Stk3 mutation
(47 available)
Stk4Gt(AJ0315)Wtsi mutation
(0 available);
any
Stk4 mutation
(72 available)
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mortality/aging
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• none survive beyond E9.5
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embryo
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• under-vascularized yolk sacs at E9.5
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• failure to turn by E9.5
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• first signs of retardation evident at embryonic day 8.5 (E8.5)
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• E8.5 embryos are smaller
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• failure to close the neural tube by E9.5
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growth/size/body
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• first signs of retardation evident at embryonic day 8.5 (E8.5)
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• E8.5 embryos are smaller
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nervous system
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• failure to close the neural tube by E9.5
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cardiovascular system
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• under-vascularized yolk sacs at E9.5
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Analysis Tools