Phenotypes for Palb2 Tg(KRT14-cre)1Amc Trp53 MGI:5495973 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Palb2^tm1.1Dli/Palb2^tm1.1Dli Trp53^tm1Brn/Trp53⁺ Tg(KRT14-cre)1Amc/0
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Palb2^tm1.1Dli mutation (1 available); any Palb2 mutation (49 available)
Tg(KRT14-cre)1Amc mutation (2 available)
Trp53^tm1Brn mutation (20 available); any Trp53 mutation (236 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:197442 )

decreased tumor latency ( J:197442 )

• mice develop mammary tumor faster than Trp53^tm1Brn/Trp53⁺ Tg(KRT14-cre)1Amc mice

integument

increased mammary gland tumor incidence ( J:197442 )

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:197442 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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