Phenotypes Associated with This Genotype

Genotype
MGI:5316466

cn18

• Allelic Composition: Yap1^tm1.1Fcam/Yap1^tm1.1Fcam; Tg(KRT14-cre)1Amc/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

impaired skin barrier function ( J:171057 )

• at E18.5 in limbs, ears, nose, and mouth

abnormal epidermal layer morphology ( J:171057 )

• at E18.5, mice lack epidermal tissue covering the distal part of the limbs, eyes and ears

• disorganized architecture

abnormal epidermis stratum basale morphology ( J:171057 )

• basal cells lose their columnar organization and adopt a flat morphology unlike in control mice

thin epidermis stratum basale ( J:171057 )

• hypoplastic

abnormal epidermis stratum corneum morphology ( J:171057 )

• reduced

thin epidermis ( J:171057 )

abnormal skin condition ( J:171057 )

• fragile at E18.5

thin skin ( J:171057 )

• at E18.5

abnormal epidermal stem cell morphology ( J:171057 )

• mice exhibit a greater than 50-fold decrease in the number of colony-forming cells compared with control mice

cellular

decreased cell proliferation ( J:171057 )

• mice exhibit a greater than 3.5-fold decrease in cell proliferation in limb skin compared with control mice

increased cell proliferation ( J:171057 )

• mice exhibit a more than 3-fold increase in cell proliferation in back skin compared with control mice

homeostasis/metabolism

impaired skin barrier function ( J:171057 )

• at E18.5 in limbs, ears, nose, and mouth